Incidental Mutation 'R3899:Prdx3'
ID 308912
Institutional Source Beutler Lab
Gene Symbol Prdx3
Ensembl Gene ENSMUSG00000024997
Gene Name peroxiredoxin 3
Synonyms SP22, D0Tohi1, Ef2l, TDXM, Mer5, Prx III, Aop1
MMRRC Submission 040809-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.400) question?
Stock # R3899 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 60852504-60862976 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 60853621 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 235 (T235S)
Ref Sequence ENSEMBL: ENSMUSP00000025961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025961] [ENSMUST00000080806] [ENSMUST00000124921] [ENSMUST00000135808]
AlphaFold P20108
Predicted Effect probably benign
Transcript: ENSMUST00000025961
AA Change: T235S

PolyPhen 2 Score 0.435 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000025961
Gene: ENSMUSG00000024997
AA Change: T235S

DomainStartEndE-ValueType
low complexity region 11 27 N/A INTRINSIC
Pfam:Redoxin 59 215 8.5e-19 PFAM
Pfam:AhpC-TSA 66 199 3.6e-39 PFAM
Pfam:1-cysPrx_C 219 254 1.2e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080806
Predicted Effect probably benign
Transcript: ENSMUST00000124921
Predicted Effect probably benign
Transcript: ENSMUST00000135808
SMART Domains Protein: ENSMUSP00000118743
Gene: ENSMUSG00000063698

DomainStartEndE-ValueType
Pfam:Mtc 11 313 2.1e-67 PFAM
Meta Mutation Damage Score 0.2051 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
PHENOTYPE: Homozygotes for a null allele show increased fat mass, adipocyte hypertrophy, mitochondrial dysfunction, oxidative stress, adipokine dysregulation and altered lipid and glucose metabolism. Homozygotes for a gene-trap allele show reduced weight and high susceptibility to LPS-induced oxidative stress. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 A G 2: 155,399,157 (GRCm39) probably benign Het
Ahctf1 A G 1: 179,605,345 (GRCm39) S730P possibly damaging Het
Ankrd26 T A 6: 118,526,389 (GRCm39) R327S probably benign Het
Anpep A G 7: 79,488,973 (GRCm39) S372P probably benign Het
Apob A T 12: 8,065,849 (GRCm39) I4273F possibly damaging Het
Ascl1 G T 10: 87,328,435 (GRCm39) H172Q probably benign Het
Azi2 A G 9: 117,876,571 (GRCm39) Y29C probably damaging Het
Baz1a A G 12: 54,981,589 (GRCm39) M355T probably benign Het
Brs3 G A X: 56,092,616 (GRCm39) V367M possibly damaging Het
Ccdc33 T C 9: 57,940,200 (GRCm39) D524G probably damaging Het
Cd300lf T C 11: 115,015,177 (GRCm39) T138A probably damaging Het
Cemip2 A G 19: 21,829,598 (GRCm39) T1236A probably benign Het
Ces1g T C 8: 94,029,678 (GRCm39) Y518C probably damaging Het
Chek2 C T 5: 111,013,479 (GRCm39) probably benign Het
Cherp A G 8: 73,223,780 (GRCm39) I201T possibly damaging Het
Cntnap2 A T 6: 45,968,837 (GRCm39) H193L probably benign Het
Crim1 C A 17: 78,588,783 (GRCm39) T286N probably benign Het
Cwc27 T A 13: 104,929,023 (GRCm39) K307* probably null Het
Dbx2 T C 15: 95,530,313 (GRCm39) D218G possibly damaging Het
Dclk1 G A 3: 55,154,750 (GRCm39) R60Q probably damaging Het
Dnah17 A T 11: 117,985,634 (GRCm39) I1481N possibly damaging Het
Dnah8 G A 17: 31,073,872 (GRCm39) R4514H probably damaging Het
Dpp10 A T 1: 123,281,286 (GRCm39) W588R probably damaging Het
Epg5 G A 18: 78,000,725 (GRCm39) E554K probably damaging Het
Eya1 T C 1: 14,340,971 (GRCm39) T139A probably benign Het
Fchsd2 A G 7: 100,841,006 (GRCm39) K172E possibly damaging Het
Foxd3 A G 4: 99,545,736 (GRCm39) Y292C unknown Het
Gli1 C T 10: 127,172,535 (GRCm39) M202I possibly damaging Het
Gm973 T C 1: 59,664,299 (GRCm39) Y634H probably benign Het
Gpr132 G T 12: 112,815,728 (GRCm39) A366E probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Kcnq3 C T 15: 65,902,372 (GRCm39) M201I probably benign Het
Khdc3 T C 9: 73,011,628 (GRCm39) probably benign Het
Lrrc37a A G 11: 103,388,372 (GRCm39) V2351A unknown Het
Mmrn2 G T 14: 34,121,517 (GRCm39) probably null Het
Mtr A T 13: 12,231,735 (GRCm39) N656K probably benign Het
Mtus1 T C 8: 41,536,166 (GRCm39) T517A probably benign Het
Osgep G C 14: 51,162,200 (GRCm39) N12K probably damaging Het
Pcare A T 17: 72,057,155 (GRCm39) C841S probably benign Het
Rasa3 G A 8: 13,628,635 (GRCm39) H608Y probably benign Het
Rd3 T C 1: 191,717,217 (GRCm39) V114A probably damaging Het
Setd2 C T 9: 110,421,586 (GRCm39) R273W probably damaging Het
Slc24a1 A T 9: 64,835,426 (GRCm39) S900R probably damaging Het
Slc30a5 T C 13: 100,954,655 (GRCm39) M170V probably benign Het
Slc4a9 T C 18: 36,668,616 (GRCm39) V732A probably benign Het
Slc7a2 C T 8: 41,358,590 (GRCm39) T311M possibly damaging Het
Smarcc1 T C 9: 109,947,586 (GRCm39) probably benign Het
Stk32b A G 5: 37,614,498 (GRCm39) S337P probably damaging Het
Thop1 G A 10: 80,916,278 (GRCm39) G429S probably damaging Het
Timp2 C T 11: 118,194,542 (GRCm39) D139N probably damaging Het
Tmem45a T C 16: 56,627,101 (GRCm39) E256G probably damaging Het
Tox4 T A 14: 52,517,299 (GRCm39) Y10N probably damaging Het
Trpm3 A G 19: 22,878,524 (GRCm39) M642V possibly damaging Het
Ttll10 T C 4: 156,120,257 (GRCm39) T508A probably damaging Het
Tut7 T A 13: 59,937,069 (GRCm39) K791* probably null Het
Ubash3b C T 9: 40,942,860 (GRCm39) D211N probably benign Het
Usp36 T A 11: 118,170,650 (GRCm39) D28V possibly damaging Het
Vmn2r97 T C 17: 19,167,873 (GRCm39) I709T probably damaging Het
Zfp936 T A 7: 42,839,158 (GRCm39) N207K possibly damaging Het
Zfp946 T G 17: 22,673,531 (GRCm39) I95S probably benign Het
Zhx3 A T 2: 160,622,371 (GRCm39) S599T possibly damaging Het
Other mutations in Prdx3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02444:Prdx3 APN 19 60,859,899 (GRCm39) missense possibly damaging 0.76
IGL03114:Prdx3 APN 19 60,861,556 (GRCm39) splice site probably benign
IGL03410:Prdx3 APN 19 60,859,848 (GRCm39) splice site probably benign
R0058:Prdx3 UTSW 19 60,862,950 (GRCm39) start gained probably benign
R1612:Prdx3 UTSW 19 60,862,872 (GRCm39) missense possibly damaging 0.94
R4654:Prdx3 UTSW 19 60,853,674 (GRCm39) missense possibly damaging 0.92
R4720:Prdx3 UTSW 19 60,858,551 (GRCm39) missense possibly damaging 0.90
R4760:Prdx3 UTSW 19 60,861,621 (GRCm39) missense possibly damaging 0.63
R5643:Prdx3 UTSW 19 60,859,963 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACTCTTTGGAAGCTGTTGGAC -3'
(R):5'- AGTTGTTGGCACTAGTCCTG -3'

Sequencing Primer
(F):5'- ACTTTGTAGACCAGGCTAGACTC -3'
(R):5'- GGCACTAGTCCTGTTAATGAGG -3'
Posted On 2015-04-17