Incidental Mutation 'R3906:Fpr2'
ID 309206
Institutional Source Beutler Lab
Gene Symbol Fpr2
Ensembl Gene ENSMUSG00000052270
Gene Name formyl peptide receptor 2
Synonyms Fpr-rs2, E330010I07Rik
MMRRC Submission 040813-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R3906 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 18108086-18114214 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18113811 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 269 (K269R)
Ref Sequence ENSEMBL: ENSMUSP00000065799 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000064068] [ENSMUST00000149944]
AlphaFold O88536
Predicted Effect probably benign
Transcript: ENSMUST00000054871
SMART Domains Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 2.2e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000064068
AA Change: K269R

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000065799
Gene: ENSMUSG00000052270
AA Change: K269R

DomainStartEndE-ValueType
Pfam:7tm_1 43 302 4.3e-36 PFAM
low complexity region 326 341 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000149944
Meta Mutation Damage Score 0.1426 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 97% (36/37)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A G 4: 53,067,151 (GRCm39) V1352A possibly damaging Het
Abcb7 G T X: 103,327,765 (GRCm39) Q715K probably benign Het
Adamts3 C A 5: 90,009,214 (GRCm39) G150C probably damaging Het
Ank2 A G 3: 126,810,547 (GRCm39) L513P probably damaging Het
Cacng1 C A 11: 107,607,118 (GRCm39) V34L probably benign Het
Cd1d1 A G 3: 86,906,063 (GRCm39) W71R probably damaging Het
Cdhr3 A G 12: 33,103,427 (GRCm39) F397L probably damaging Het
Ces2a A G 8: 105,465,940 (GRCm39) I325V probably benign Het
Ctsq C T 13: 61,186,585 (GRCm39) V140M probably damaging Het
Cyp4f18 A G 8: 72,754,926 (GRCm39) probably benign Het
Ddi2 T C 4: 141,411,592 (GRCm39) D440G probably benign Het
Dsg3 G A 18: 20,671,556 (GRCm39) G754R probably damaging Het
Endod1 T A 9: 14,292,151 (GRCm39) Y39F probably benign Het
F11 A G 8: 45,701,675 (GRCm39) S353P probably damaging Het
Fn1 C T 1: 71,647,072 (GRCm39) G1482R probably damaging Het
Frk T G 10: 34,460,052 (GRCm39) L216V probably benign Het
Gan G A 8: 117,920,873 (GRCm39) V370M probably damaging Het
Grik1 A G 16: 87,803,337 (GRCm39) I285T probably benign Het
Hspa1a C T 17: 35,190,703 (GRCm39) V67M probably damaging Het
Kbtbd8 T A 6: 95,103,565 (GRCm39) Y405N probably damaging Het
Kcnj4 G T 15: 79,369,946 (GRCm39) H11Q probably benign Het
Kif26a T A 12: 112,143,324 (GRCm39) S1193T probably benign Het
Kmt2e A G 5: 23,706,624 (GRCm39) N1396D probably benign Het
Lasp1 G A 11: 97,690,653 (GRCm39) V12M probably damaging Het
Lrrk1 G T 7: 65,944,651 (GRCm39) T653K possibly damaging Het
Meiob A G 17: 25,046,922 (GRCm39) Y182C probably benign Het
Myh6 T C 14: 55,194,412 (GRCm39) D739G probably benign Het
Ninl T C 2: 150,822,039 (GRCm39) D21G probably damaging Het
Or11g27 C T 14: 50,771,211 (GRCm39) T114I probably benign Het
Or9i16 C T 19: 13,865,070 (GRCm39) C168Y probably damaging Het
Pacsin2 A C 15: 83,263,256 (GRCm39) V125G probably damaging Het
Pfas G A 11: 68,879,112 (GRCm39) probably benign Het
Pla2g4f C T 2: 120,130,980 (GRCm39) R825Q probably benign Het
Prkd1 A T 12: 50,435,209 (GRCm39) V506E possibly damaging Het
Psmd2 A G 16: 20,474,392 (GRCm39) D316G probably benign Het
Ryr2 T A 13: 11,753,095 (GRCm39) D1742V possibly damaging Het
Szt2 G A 4: 118,235,466 (GRCm39) probably benign Het
Ugt8a T C 3: 125,708,631 (GRCm39) T160A possibly damaging Het
Xrcc6 A G 15: 81,913,772 (GRCm39) T378A probably benign Het
Other mutations in Fpr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Fpr2 APN 17 18,113,034 (GRCm39) missense probably damaging 0.98
IGL01481:Fpr2 APN 17 18,113,025 (GRCm39) missense probably benign 0.01
IGL02320:Fpr2 APN 17 18,113,608 (GRCm39) missense probably benign 0.05
IGL02479:Fpr2 APN 17 18,113,074 (GRCm39) missense probably benign 0.01
R1553:Fpr2 UTSW 17 18,113,856 (GRCm39) missense possibly damaging 0.87
R4424:Fpr2 UTSW 17 18,113,394 (GRCm39) missense probably damaging 1.00
R4480:Fpr2 UTSW 17 18,114,015 (GRCm39) missense probably benign 0.01
R4521:Fpr2 UTSW 17 18,113,509 (GRCm39) missense probably benign 0.01
R4718:Fpr2 UTSW 17 18,113,598 (GRCm39) missense probably benign 0.00
R5385:Fpr2 UTSW 17 18,113,309 (GRCm39) missense probably benign 0.00
R7184:Fpr2 UTSW 17 18,113,533 (GRCm39) missense unknown
R7233:Fpr2 UTSW 17 18,113,766 (GRCm39) missense probably damaging 1.00
R8902:Fpr2 UTSW 17 18,113,190 (GRCm39) missense probably benign 0.04
R8927:Fpr2 UTSW 17 18,113,724 (GRCm39) missense possibly damaging 0.77
R8928:Fpr2 UTSW 17 18,113,724 (GRCm39) missense possibly damaging 0.77
R8939:Fpr2 UTSW 17 18,113,883 (GRCm39) missense probably damaging 1.00
R9410:Fpr2 UTSW 17 18,113,604 (GRCm39) missense probably benign
R9651:Fpr2 UTSW 17 18,113,484 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGCCCATGTCAATTGTTGCTG -3'
(R):5'- CTCAATGTCTGCAGGAGGTGAAG -3'

Sequencing Primer
(F):5'- CTGTTTGCTATGGACTCATTGC -3'
(R):5'- GGTTTGACCAGAATCCTCACTCAG -3'
Posted On 2015-04-17