Incidental Mutation 'R3909:Olfr1251'
ID309292
Institutional Source Beutler Lab
Gene Symbol Olfr1251
Ensembl Gene ENSMUSG00000111567
Gene Nameolfactory receptor 1251
SynonymsMOR231-15P, MOR231-24_p, GA_x6K02T2Q125-51109312-51108356
MMRRC Submission 040814-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.455) question?
Stock #R3909 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location89665870-89671936 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 89667013 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 291 (E291G)
Ref Sequence ENSEMBL: ENSMUSP00000150028 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214304] [ENSMUST00000214639] [ENSMUST00000214750]
Predicted Effect probably damaging
Transcript: ENSMUST00000099767
AA Change: E291G

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097355
Gene: ENSMUSG00000075077
AA Change: E291G

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.1e-45 PFAM
Pfam:7tm_1 39 285 2.3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000188085
AA Change: E291G

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000140591
Gene: ENSMUSG00000100323
AA Change: E291G

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.4e-29 PFAM
Pfam:7tm_4 137 278 2e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214304
AA Change: E291G

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000214639
AA Change: E291G

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000214750
AA Change: E291G

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (35/35)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T A 6: 121,648,166 F501Y probably damaging Het
Alk T C 17: 71,897,911 T1089A probably benign Het
Ankrd12 G T 17: 65,984,005 P1478T probably benign Het
Arhgap39 A G 15: 76,751,888 V49A probably benign Het
Arid4b T C 13: 14,132,484 L108P probably damaging Het
Atrn T A 2: 130,994,207 C1136S probably damaging Het
Cacna1s T A 1: 136,084,269 M483K probably damaging Het
Cacng1 C A 11: 107,716,292 V34L probably benign Het
Casp8 T C 1: 58,844,811 S446P probably damaging Het
Cngb3 G A 4: 19,461,679 C520Y probably damaging Het
Crim1 C T 17: 78,281,239 probably benign Het
F11 A G 8: 45,248,638 S353P probably damaging Het
Fbxl17 G A 17: 63,499,807 P71S possibly damaging Het
Fn1 C T 1: 71,607,913 G1482R probably damaging Het
Gbp3 C T 3: 142,566,338 probably benign Het
Golga4 A G 9: 118,558,736 D1642G possibly damaging Het
Hspa1a C T 17: 34,971,727 V67M probably damaging Het
Hyls1 T C 9: 35,561,409 D237G probably damaging Het
Kmt2e A G 5: 23,501,626 N1396D probably benign Het
Lasp1 G A 11: 97,799,827 V12M probably damaging Het
Muc4 G C 16: 32,753,919 R1265P probably benign Het
Muc5b C T 7: 141,849,498 T732M unknown Het
Mxd1 G T 6: 86,650,960 Q199K probably benign Het
Olfr1143 T A 2: 87,802,687 F95L probably benign Het
Olfr1153 T A 2: 87,896,949 probably null Het
Olfr304 T A 7: 86,385,974 T229S probably benign Het
Prps1l1 A T 12: 34,985,798 H304L possibly damaging Het
Psmd2 A G 16: 20,655,642 D316G probably benign Het
Rlf G A 4: 121,149,032 T917I probably benign Het
Ryr3 T C 2: 112,636,608 D4704G probably damaging Het
Scn1a T A 2: 66,273,988 I1643F probably damaging Het
Vmn2r38 T C 7: 9,075,554 K610E probably damaging Het
Zfc3h1 T C 10: 115,419,901 F1486L probably benign Het
Other mutations in Olfr1251
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01817:Olfr1251 APN 2 89667004 missense probably benign 0.00
IGL01941:Olfr1251 APN 2 89667468 nonsense probably null 0.00
IGL01988:Olfr1251 APN 2 89667080 missense probably benign 0.07
IGL02388:Olfr1251 APN 2 89666972 missense probably benign 0.00
IGL03169:Olfr1251 APN 2 89667487 missense possibly damaging 0.86
R0008:Olfr1251 UTSW 2 89667084 missense probably damaging 1.00
R0042:Olfr1251 UTSW 2 89667454 missense probably benign 0.01
R0834:Olfr1251 UTSW 2 89667079 missense probably benign 0.24
R1102:Olfr1251 UTSW 2 89667470 missense probably damaging 0.98
R2213:Olfr1251 UTSW 2 89667547 missense probably damaging 1.00
R2219:Olfr1251 UTSW 2 89667867 missense possibly damaging 0.73
R3023:Olfr1251 UTSW 2 89667646 missense possibly damaging 0.86
R3105:Olfr1251 UTSW 2 89666958 missense probably benign 0.01
R3433:Olfr1251 UTSW 2 89667233 missense probably benign 0.01
R3508:Olfr1251 UTSW 2 89667472 missense probably benign 0.14
R3758:Olfr1251 UTSW 2 89667572 missense probably benign 0.14
R4049:Olfr1251 UTSW 2 89667662 missense probably benign 0.03
R4457:Olfr1251 UTSW 2 89667083 missense probably benign 0.24
R5613:Olfr1251 UTSW 2 89667044 missense probably damaging 1.00
R5748:Olfr1251 UTSW 2 89667802 missense possibly damaging 0.67
R6226:Olfr1251 UTSW 2 89666989 missense probably damaging 1.00
R6950:Olfr1251 UTSW 2 89667551 missense probably benign 0.07
Predicted Primers PCR Primer
(F):5'- ACCAGTAGTTTCACAGTATCAAGTG -3'
(R):5'- CCTACTCTCCTATGGAATAATCCTTAG -3'

Sequencing Primer
(F):5'- CAAGTGGTAGTGTGAATGTTCAAGC -3'
(R):5'- TAGATCTCTCAAGAATCACAGTCAGG -3'
Posted On2015-04-17