Incidental Mutation 'R3909:Vmn2r38'
ID 309303
Institutional Source Beutler Lab
Gene Symbol Vmn2r38
Ensembl Gene ENSMUSG00000095773
Gene Name vomeronasal 2, receptor 38
Synonyms
MMRRC Submission 040814-MU
Accession Numbers
Essential gene? Not available question?
Stock # R3909 (G1)
Quality Score 157
Status Not validated
Chromosome 7
Chromosomal Location 9077795-9100764 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 9078553 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 610 (K610E)
Ref Sequence ENSEMBL: ENSMUSP00000104194 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108554]
AlphaFold G3UYA8
Predicted Effect probably damaging
Transcript: ENSMUST00000108554
AA Change: K610E

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104194
Gene: ENSMUSG00000095773
AA Change: K610E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 3.5e-33 PFAM
Pfam:NCD3G 512 565 1.4e-20 PFAM
Pfam:7tm_3 598 833 6.4e-54 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (35/35)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T A 6: 121,625,125 (GRCm39) F501Y probably damaging Het
Alk T C 17: 72,204,906 (GRCm39) T1089A probably benign Het
Ankrd12 G T 17: 66,291,000 (GRCm39) P1478T probably benign Het
Arhgap39 A G 15: 76,636,088 (GRCm39) V49A probably benign Het
Arid4b T C 13: 14,307,069 (GRCm39) L108P probably damaging Het
Atrn T A 2: 130,836,127 (GRCm39) C1136S probably damaging Het
Cacna1s T A 1: 136,012,007 (GRCm39) M483K probably damaging Het
Cacng1 C A 11: 107,607,118 (GRCm39) V34L probably benign Het
Casp8 T C 1: 58,883,970 (GRCm39) S446P probably damaging Het
Cngb3 G A 4: 19,461,679 (GRCm39) C520Y probably damaging Het
Crim1 C T 17: 78,588,668 (GRCm39) probably benign Het
F11 A G 8: 45,701,675 (GRCm39) S353P probably damaging Het
Fbxl17 G A 17: 63,806,802 (GRCm39) P71S possibly damaging Het
Fn1 C T 1: 71,647,072 (GRCm39) G1482R probably damaging Het
Gbp3 C T 3: 142,272,099 (GRCm39) probably benign Het
Golga4 A G 9: 118,387,804 (GRCm39) D1642G possibly damaging Het
Hspa1a C T 17: 35,190,703 (GRCm39) V67M probably damaging Het
Hyls1 T C 9: 35,472,705 (GRCm39) D237G probably damaging Het
Kmt2e A G 5: 23,706,624 (GRCm39) N1396D probably benign Het
Lasp1 G A 11: 97,690,653 (GRCm39) V12M probably damaging Het
Muc4 G C 16: 32,753,919 (GRCm38) R1265P probably benign Het
Muc5b C T 7: 141,403,235 (GRCm39) T732M unknown Het
Mxd1 G T 6: 86,627,942 (GRCm39) Q199K probably benign Het
Or14a258 T A 7: 86,035,182 (GRCm39) T229S probably benign Het
Or4a78 T C 2: 89,497,357 (GRCm39) E291G probably damaging Het
Or5w18 T A 2: 87,633,031 (GRCm39) F95L probably benign Het
Or5w20 T A 2: 87,727,293 (GRCm39) probably null Het
Prps1l1 A T 12: 35,035,797 (GRCm39) H304L possibly damaging Het
Psmd2 A G 16: 20,474,392 (GRCm39) D316G probably benign Het
Rlf G A 4: 121,006,229 (GRCm39) T917I probably benign Het
Ryr3 T C 2: 112,466,953 (GRCm39) D4704G probably damaging Het
Scn1a T A 2: 66,104,332 (GRCm39) I1643F probably damaging Het
Zfc3h1 T C 10: 115,255,806 (GRCm39) F1486L probably benign Het
Other mutations in Vmn2r38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02805:Vmn2r38 APN 7 9,078,546 (GRCm39) missense probably damaging 0.99
IGL03199:Vmn2r38 APN 7 9,078,375 (GRCm39) missense probably damaging 1.00
R1619:Vmn2r38 UTSW 7 9,078,532 (GRCm39) missense probably damaging 1.00
R3154:Vmn2r38 UTSW 7 9,097,689 (GRCm39) missense probably benign 0.03
R4302:Vmn2r38 UTSW 7 9,100,562 (GRCm39) splice site probably null
R5106:Vmn2r38 UTSW 7 9,078,169 (GRCm39) missense possibly damaging 0.85
R5187:Vmn2r38 UTSW 7 9,100,571 (GRCm39) missense probably benign 0.03
R5575:Vmn2r38 UTSW 7 9,078,635 (GRCm39) nonsense probably null
R5653:Vmn2r38 UTSW 7 9,100,764 (GRCm39) start codon destroyed probably null 1.00
R6156:Vmn2r38 UTSW 7 9,097,611 (GRCm39) missense probably damaging 0.99
R6970:Vmn2r38 UTSW 7 9,078,340 (GRCm39) nonsense probably null
R7107:Vmn2r38 UTSW 7 9,093,728 (GRCm39) missense probably benign 0.00
R7231:Vmn2r38 UTSW 7 9,100,637 (GRCm39) missense possibly damaging 0.88
R7419:Vmn2r38 UTSW 7 9,078,354 (GRCm39) missense probably damaging 1.00
R7963:Vmn2r38 UTSW 7 9,095,854 (GRCm39) missense probably benign 0.17
R8788:Vmn2r38 UTSW 7 9,078,482 (GRCm39) missense probably benign 0.02
R9639:Vmn2r38 UTSW 7 9,078,063 (GRCm39) missense probably damaging 0.96
R9773:Vmn2r38 UTSW 7 9,097,806 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGACTGTTTTGGCCAGAACTG -3'
(R):5'- CAGACCTAACTAAGCTTTCCTTTGG -3'

Sequencing Primer
(F):5'- TTTTGGCCAGAACTGTGGAAAC -3'
(R):5'- TGGAAATCAGATATGGATCAATGTG -3'
Posted On 2015-04-17