Incidental Mutation 'R3910:Or9a2'
ID 309337
Institutional Source Beutler Lab
Gene Symbol Or9a2
Ensembl Gene ENSMUSG00000045479
Gene Name olfactory receptor family 9 subfamily A member 2
Synonyms GA_x6K02T2P3E9-5780974-5781915, Olfr459, MOR120-1
MMRRC Submission 040815-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.200) question?
Stock # R3910 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 41748287-41749231 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 41749083 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 50 (V50A)
Ref Sequence ENSEMBL: ENSMUSP00000149928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050412] [ENSMUST00000214752] [ENSMUST00000214976]
AlphaFold Q924H8
Predicted Effect probably benign
Transcript: ENSMUST00000050412
AA Change: V50A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000061622
Gene: ENSMUSG00000045479
AA Change: V50A

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 7.9e-46 PFAM
Pfam:7TM_GPCR_Srsx 34 304 1.7e-6 PFAM
Pfam:7tm_1 40 290 6.2e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203430
AA Change: V50A
SMART Domains Protein: ENSMUSP00000145036
Gene: ENSMUSG00000045479
AA Change: V50A

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 7.9e-46 PFAM
Pfam:7TM_GPCR_Srsx 34 304 1.7e-6 PFAM
Pfam:7tm_1 40 290 6.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214752
AA Change: V50A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000214976
AA Change: V50A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.1353 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 97% (36/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bod1l T C 5: 41,974,441 (GRCm39) E2291G probably damaging Het
Cchcr1 T C 17: 35,836,233 (GRCm39) V341A probably damaging Het
Cimip3 AC A 17: 47,744,348 (GRCm39) probably benign Het
Dsg1c T C 18: 20,399,253 (GRCm39) V119A possibly damaging Het
Fap A G 2: 62,386,448 (GRCm39) S58P probably damaging Het
Flnc A T 6: 29,459,426 (GRCm39) T2509S probably damaging Het
Fnip2 A T 3: 79,386,812 (GRCm39) D971E possibly damaging Het
Gab2 A G 7: 96,948,280 (GRCm39) Y290C probably damaging Het
Gm7104 C T 12: 88,251,364 (GRCm39) noncoding transcript Het
Ints10 T A 8: 69,266,272 (GRCm39) S478T probably damaging Het
Iqca1l A T 5: 24,750,440 (GRCm39) probably benign Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Krt90 G A 15: 101,471,218 (GRCm39) R15W probably damaging Het
Lgr5 A G 10: 115,423,368 (GRCm39) S11P possibly damaging Het
Mycn T A 12: 12,987,281 (GRCm39) N372I probably damaging Het
Or2ag18 A T 7: 106,405,072 (GRCm39) V199D probably damaging Het
Paxbp1 T A 16: 90,839,569 (GRCm39) E117V probably damaging Het
Phc2 T C 4: 128,637,351 (GRCm39) probably null Het
Prr5 T A 15: 84,587,345 (GRCm39) V365E probably benign Het
Rev3l A G 10: 39,696,552 (GRCm39) I521M probably damaging Het
Robo3 A T 9: 37,330,591 (GRCm39) Y1002N probably damaging Het
Svep1 A T 4: 58,145,156 (GRCm39) probably null Het
Thsd7a A G 6: 12,331,548 (GRCm39) V1342A probably damaging Het
Tmtc3 A C 10: 100,284,888 (GRCm39) N582K probably damaging Het
Tnfrsf11b G A 15: 54,119,578 (GRCm39) probably benign Het
Trim30a A G 7: 104,060,348 (GRCm39) V476A probably damaging Het
Ugt1a8 A G 1: 88,015,770 (GRCm39) E61G possibly damaging Het
Vmn1r75 A T 7: 11,614,757 (GRCm39) N163I possibly damaging Het
Vps35l A G 7: 118,345,613 (GRCm39) T49A possibly damaging Het
Zfp119a G A 17: 56,173,520 (GRCm39) L108F probably benign Het
Other mutations in Or9a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Or9a2 APN 6 41,749,047 (GRCm39) missense probably damaging 1.00
IGL01460:Or9a2 APN 6 41,749,216 (GRCm39) missense probably benign 0.12
IGL02465:Or9a2 APN 6 41,748,490 (GRCm39) missense probably damaging 1.00
R0352:Or9a2 UTSW 6 41,749,058 (GRCm39) missense probably damaging 0.99
R0443:Or9a2 UTSW 6 41,748,829 (GRCm39) missense possibly damaging 0.75
R0480:Or9a2 UTSW 6 41,749,198 (GRCm39) missense probably benign 0.01
R1491:Or9a2 UTSW 6 41,748,456 (GRCm39) missense possibly damaging 0.95
R1495:Or9a2 UTSW 6 41,748,837 (GRCm39) missense probably damaging 1.00
R2103:Or9a2 UTSW 6 41,748,939 (GRCm39) missense probably benign 0.36
R3688:Or9a2 UTSW 6 41,749,160 (GRCm39) nonsense probably null
R4709:Or9a2 UTSW 6 41,748,442 (GRCm39) missense probably benign 0.06
R4710:Or9a2 UTSW 6 41,748,442 (GRCm39) missense probably benign 0.06
R4960:Or9a2 UTSW 6 41,749,003 (GRCm39) missense probably damaging 0.97
R5162:Or9a2 UTSW 6 41,748,706 (GRCm39) missense possibly damaging 0.80
R5236:Or9a2 UTSW 6 41,749,045 (GRCm39) missense probably benign 0.00
R5441:Or9a2 UTSW 6 41,748,782 (GRCm39) missense probably benign 0.00
R7171:Or9a2 UTSW 6 41,748,961 (GRCm39) missense probably benign 0.09
R7400:Or9a2 UTSW 6 41,748,678 (GRCm39) missense probably damaging 1.00
R8115:Or9a2 UTSW 6 41,748,472 (GRCm39) missense probably benign 0.00
R8346:Or9a2 UTSW 6 41,749,057 (GRCm39) missense probably damaging 1.00
R8363:Or9a2 UTSW 6 41,748,684 (GRCm39) missense probably benign 0.06
R9573:Or9a2 UTSW 6 41,748,940 (GRCm39) missense probably benign 0.00
R9700:Or9a2 UTSW 6 41,749,076 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCCAAGCACTGCAAACTCTG -3'
(R):5'- GAAGGATCTGTTTGATGCAGACC -3'

Sequencing Primer
(F):5'- TGCAAACTCTGTGGTCCCTAGAG -3'
(R):5'- TGATGCAGACCTACAACTTGG -3'
Posted On 2015-04-17