Mutagenetix > Incidental Mutation

Incidental Mutation 'R3886:Gm8674'

309665

Institutional Source

Beutler Lab

Gene Symbol

Gm8674

Ensembl Gene

ENSMUSG00000093976

Gene Name

predicted gene 8674

Synonyms

MMRRC Submission

040798-MU

Accession Numbers

Genbank: XM_990959; MGI: 3645762

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R3886 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

49899119-49904597 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 49902163 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179367

SMART Domains

Protein: ENSMUSP00000137219
Gene: ENSMUSG00000093976

Domain	Start	End	E-Value	Type
low complexity region	70	86	N/A	INTRINSIC
Pfam:FAM75	92	444	3.6e-27	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.4%
20x: 95.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310035C23Rik	A	G	1: 105,692,213	N331S	probably benign	Het
2410089E03Rik	T	A	15: 8,171,805	V22E	probably damaging	Het
4933407L21Rik	T	A	1: 85,940,551		probably null	Het
Adam17	G	A	12: 21,325,587	R744C	probably damaging	Het
Adss	A	G	1: 177,767,769	Y402H	probably damaging	Het
B020004J07Rik	T	C	4: 101,835,723	K360R	probably benign	Het
Ccdc73	A	T	2: 104,991,343	T546S	possibly damaging	Het
Cd22	T	C	7: 30,870,107	D354G	possibly damaging	Het
Chchd6	T	C	6: 89,467,451	E183G	probably damaging	Het
Col6a5	A	G	9: 105,930,930	L973P	unknown	Het
Cp	T	C	3: 19,989,111	L1021P	probably damaging	Het
Cps1	C	A	1: 67,165,500	T493K	possibly damaging	Het
D630045J12Rik	A	G	6: 38,142,698	V1703A	possibly damaging	Het
Dennd1a	T	C	2: 37,858,077	N376S	possibly damaging	Het
Dmxl1	T	A	18: 49,878,259	M1161K	probably damaging	Het
Ect2l	C	T	10: 18,168,458	V310M	probably damaging	Het
Fn1	T	C	1: 71,640,306	Y511C	probably damaging	Het
Foxd2	T	C	4: 114,908,286	H179R	unknown	Het
Ice1	T	C	13: 70,605,370	T866A	probably benign	Het
Jade2	C	T	11: 51,830,499	V201I	possibly damaging	Het
Kcnb2	T	C	1: 15,710,415	S504P	probably damaging	Het
Kcng4	T	C	8: 119,633,247	K130R	probably benign	Het
Lcor	T	A	19: 41,558,356	S126R	probably damaging	Het
Lct	T	C	1: 128,304,226	M629V	probably damaging	Het
Lrch2	C	G	X: 147,473,007	A437P	probably damaging	Het
Lrrk1	C	T	7: 66,292,364	V709I	probably damaging	Het
Mdh1	A	G	11: 21,559,832	V181A	probably damaging	Het
Olfr1243	T	A	2: 89,527,732	H226L	possibly damaging	Het
Olfr978	A	G	9: 39,994,539	H243R	probably damaging	Het
Papd5	C	A	8: 88,200,415	A151E	probably benign	Het
Ppp1r3a	A	C	6: 14,719,912	D334E	possibly damaging	Het
Ptpro	T	A	6: 137,443,594	V1007D	probably damaging	Het
Rbm45	A	G	2: 76,375,424	S207G	probably benign	Het
Robo3	G	A	9: 37,422,181	Q723*	probably null	Het
Rreb1	G	A	13: 37,898,506		probably null	Het
Slc35f2	T	A	9: 53,816,957	S372T	probably benign	Het
Slitrk5	T	A	14: 111,679,797	C284*	probably null	Het
Snapc4	G	A	2: 26,365,498	Q1005*	probably null	Het
Tnxb	A	G	17: 34,718,911	D3896G	probably damaging	Het
Tti1	A	G	2: 158,008,950	V123A	possibly damaging	Het
Usp1	T	C	4: 98,929,736	C147R	probably damaging	Het
Vill	A	G	9: 119,066,714	N106S	probably benign	Het

Other mutations in Gm8674

Allele	Source	Chr	Coord	Type	Predicted Effect
R0355:Gm8674	UTSW	13	49901939	exon	noncoding transcript
R0357:Gm8674	UTSW	13	49902113	exon	noncoding transcript
R0627:Gm8674	UTSW	13	49899715	exon	noncoding transcript
R0833:Gm8674	UTSW	13	49904575	exon	noncoding transcript
R1300:Gm8674	UTSW	13	49901722	exon	noncoding transcript
R1452:Gm8674	UTSW	13	49900517	exon	noncoding transcript
R1542:Gm8674	UTSW	13	49900003	exon	noncoding transcript
R1613:Gm8674	UTSW	13	49902438	intron	noncoding transcript
R1643:Gm8674	UTSW	13	49901358	exon	noncoding transcript
R1732:Gm8674	UTSW	13	49901926	exon	noncoding transcript
R1824:Gm8674	UTSW	13	49900808	exon	noncoding transcript
R1840:Gm8674	UTSW	13	49901765	exon	noncoding transcript
R1915:Gm8674	UTSW	13	49900853	exon	noncoding transcript
R1934:Gm8674	UTSW	13	49901435	exon	noncoding transcript
R2040:Gm8674	UTSW	13	49901669	exon	noncoding transcript
R2214:Gm8674	UTSW	13	49901360	exon	noncoding transcript
R2421:Gm8674	UTSW	13	49900663	exon	noncoding transcript
R3423:Gm8674	UTSW	13	49901756	exon	noncoding transcript
R3425:Gm8674	UTSW	13	49901756	exon	noncoding transcript
R4083:Gm8674	UTSW	13	49901011	exon	noncoding transcript
R4343:Gm8674	UTSW	13	49899706	exon	noncoding transcript
R4570:Gm8674	UTSW	13	49902534	intron	noncoding transcript
R4936:Gm8674	UTSW	13	49900755	exon	noncoding transcript
R4967:Gm8674	UTSW	13	49901998	exon	noncoding transcript
R5065:Gm8674	UTSW	13	49902577	intron	noncoding transcript
R5067:Gm8674	UTSW	13	49899834	exon	noncoding transcript
R5120:Gm8674	UTSW	13	49901948	exon	noncoding transcript
R5208:Gm8674	UTSW	13	49901921	exon	noncoding transcript
R5268:Gm8674	UTSW	13	49901354	exon	noncoding transcript
R5471:Gm8674	UTSW	13	49900813	exon	noncoding transcript
R5773:Gm8674	UTSW	13	49901876	exon	noncoding transcript
R5809:Gm8674	UTSW	13	49901888	exon	noncoding transcript
R8162:Gm8674	UTSW	13	49900371	missense	noncoding transcript
R8239:Gm8674	UTSW	13	49900226	missense	noncoding transcript
Z1088:Gm8674	UTSW	13	49900794	exon	noncoding transcript
Z1088:Gm8674	UTSW	13	49901248	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- TTGTGTCACAATTTCCAGAGGC -3'
(R):5'- TGACAAAGACTGATGGCCATAC -3'

Sequencing Primer
(F):5'- TGTCACAATTTCCAGAGGCAATGG -3'
(R):5'- GACTGATGGCCATACTGATCC -3'

Posted On

2015-04-17