Incidental Mutation 'R3887:Ceacam14'
ID309697
Institutional Source Beutler Lab
Gene Symbol Ceacam14
Ensembl Gene ENSMUSG00000023185
Gene Namecarcinoembryonic antigen-related cell adhesion molecule 14
Synonyms1600025E09Rik, 1600021E03Rik
MMRRC Submission 040799-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R3887 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location17812633-17815663 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 17814138 bp
ZygosityHeterozygous
Amino Acid Change Valine to Aspartic acid at position 51 (V51D)
Ref Sequence ENSEMBL: ENSMUSP00000023953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023953]
Predicted Effect probably damaging
Transcript: ENSMUST00000023953
AA Change: V51D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023953
Gene: ENSMUSG00000023185
AA Change: V51D

DomainStartEndE-ValueType
low complexity region 18 29 N/A INTRINSIC
IG_like 40 141 6.35e0 SMART
IG_like 158 261 2.73e1 SMART
Meta Mutation Damage Score 0.5271 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933407L21Rik T A 1: 85,940,551 probably null Het
Ankdd1a C A 9: 65,502,248 G469W probably damaging Het
Ano6 A C 15: 95,894,449 T65P possibly damaging Het
Arhgap26 G A 18: 39,229,966 probably null Het
Ccdc175 A G 12: 72,136,048 I399T possibly damaging Het
Cerk A T 15: 86,149,331 I297N possibly damaging Het
Cps1 C A 1: 67,165,500 T493K possibly damaging Het
Dmxl1 T A 18: 49,878,259 M1161K probably damaging Het
Efcab14 T A 4: 115,738,660 M1K probably null Het
Etl4 C T 2: 20,529,961 Q76* probably null Het
Fmc1 T C 6: 38,539,288 S90P probably benign Het
Fn1 T C 1: 71,640,306 Y511C probably damaging Het
Foxd2 T C 4: 114,908,286 H179R unknown Het
Hk2 C T 6: 82,734,961 D548N possibly damaging Het
Lct T C 1: 128,304,226 M629V probably damaging Het
Lrp5 G A 19: 3,612,330 R173C probably damaging Het
Mapk12 A T 15: 89,135,637 H122Q possibly damaging Het
Mdfic C T 6: 15,799,711 T279I probably damaging Het
Mycbp2 A G 14: 103,174,797 V2580A probably damaging Het
Mylk3 A G 8: 85,352,047 I476T probably damaging Het
Ncapg G A 5: 45,674,363 V184I probably benign Het
Olfr1243 T A 2: 89,527,732 H226L possibly damaging Het
Pla2g15 A G 8: 106,161,135 Y185C probably damaging Het
Ptpro T A 6: 137,443,594 V1007D probably damaging Het
Rbm45 A G 2: 76,375,424 S207G probably benign Het
Reln T C 5: 21,910,849 I3054V possibly damaging Het
Rreb1 G T 13: 37,893,965 R51L probably damaging Het
Scube2 A T 7: 109,843,176 probably benign Het
Slc15a2 A G 16: 36,782,304 F65S probably damaging Het
Slc17a8 G T 10: 89,591,138 probably benign Het
Snapc4 G A 2: 26,365,498 Q1005* probably null Het
Stag3 A G 5: 138,298,839 I550M probably damaging Het
Steap4 G T 5: 7,980,494 R450L probably damaging Het
Strn4 T C 7: 16,822,998 probably benign Het
Stxbp3 C T 3: 108,805,233 probably null Het
Syngr1 A G 15: 80,116,039 D117G probably damaging Het
Tbc1d10b A T 7: 127,199,795 I513N possibly damaging Het
Other mutations in Ceacam14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Ceacam14 APN 7 17814137 missense probably damaging 1.00
R0452:Ceacam14 UTSW 7 17815323 missense probably benign
R1613:Ceacam14 UTSW 7 17814048 splice site probably benign
R1990:Ceacam14 UTSW 7 17815365 nonsense probably null
R2153:Ceacam14 UTSW 7 17814228 missense probably benign 0.00
R4724:Ceacam14 UTSW 7 17814050 critical splice acceptor site probably null
R5323:Ceacam14 UTSW 7 17815477 makesense probably null
R5454:Ceacam14 UTSW 7 17814185 missense probably damaging 1.00
R5696:Ceacam14 UTSW 7 17814342 missense probably damaging 0.97
R6318:Ceacam14 UTSW 7 17814312 missense probably damaging 1.00
R6763:Ceacam14 UTSW 7 17815343 missense probably benign 0.04
R7607:Ceacam14 UTSW 7 17814321 missense possibly damaging 0.95
R7789:Ceacam14 UTSW 7 17814171 missense probably damaging 0.99
R8946:Ceacam14 UTSW 7 17814074 missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTCAACTCAGGACACAGATC -3'
(R):5'- TTTGCATCAAGTATCCGTAGAGTG -3'

Sequencing Primer
(F):5'- AGGACACAGATCTCATCTTTCC -3'
(R):5'- GTGACACTCTTGATCAGCAGAGATC -3'
Posted On2015-04-17