Mutagenetix > Incidental Mutation

Incidental Mutation 'R3887:Ceacam14'

309697

Institutional Source

Beutler Lab

Gene Symbol

Ceacam14

Ensembl Gene

ENSMUSG00000023185

Gene Name

carcinoembryonic antigen-related cell adhesion molecule 14

Synonyms

1600025E09Rik, 1600021E03Rik

MMRRC Submission

040799-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R3887 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

17812633-17815663 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 17814138 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 51 (V51D)

Ref Sequence

ENSEMBL: ENSMUSP00000023953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023953]

AlphaFold

Q78Y72

Predicted Effect

probably damaging
Transcript: ENSMUST00000023953
AA Change: V51D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000023953
Gene: ENSMUSG00000023185
AA Change: V51D

Domain	Start	End	E-Value	Type
low complexity region	18	29	N/A	INTRINSIC
IG_like	40	141	6.35e0	SMART
IG_like	158	261	2.73e1	SMART

Meta Mutation Damage Score

0.5271

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

100% (40/40)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933407L21Rik	T	A	1: 85,940,551		probably null	Het
Ankdd1a	C	A	9: 65,502,248	G469W	probably damaging	Het
Ano6	A	C	15: 95,894,449	T65P	possibly damaging	Het
Arhgap26	G	A	18: 39,229,966		probably null	Het
Ccdc175	A	G	12: 72,136,048	I399T	possibly damaging	Het
Cerk	A	T	15: 86,149,331	I297N	possibly damaging	Het
Cps1	C	A	1: 67,165,500	T493K	possibly damaging	Het
Dmxl1	T	A	18: 49,878,259	M1161K	probably damaging	Het
Efcab14	T	A	4: 115,738,660	M1K	probably null	Het
Etl4	C	T	2: 20,529,961	Q76*	probably null	Het
Fmc1	T	C	6: 38,539,288	S90P	probably benign	Het
Fn1	T	C	1: 71,640,306	Y511C	probably damaging	Het
Foxd2	T	C	4: 114,908,286	H179R	unknown	Het
Hk2	C	T	6: 82,734,961	D548N	possibly damaging	Het
Lct	T	C	1: 128,304,226	M629V	probably damaging	Het
Lrp5	G	A	19: 3,612,330	R173C	probably damaging	Het
Mapk12	A	T	15: 89,135,637	H122Q	possibly damaging	Het
Mdfic	C	T	6: 15,799,711	T279I	probably damaging	Het
Mycbp2	A	G	14: 103,174,797	V2580A	probably damaging	Het
Mylk3	A	G	8: 85,352,047	I476T	probably damaging	Het
Ncapg	G	A	5: 45,674,363	V184I	probably benign	Het
Olfr1243	T	A	2: 89,527,732	H226L	possibly damaging	Het
Pla2g15	A	G	8: 106,161,135	Y185C	probably damaging	Het
Ptpro	T	A	6: 137,443,594	V1007D	probably damaging	Het
Rbm45	A	G	2: 76,375,424	S207G	probably benign	Het
Reln	T	C	5: 21,910,849	I3054V	possibly damaging	Het
Rreb1	G	T	13: 37,893,965	R51L	probably damaging	Het
Scube2	A	T	7: 109,843,176		probably benign	Het
Slc15a2	A	G	16: 36,782,304	F65S	probably damaging	Het
Slc17a8	G	T	10: 89,591,138		probably benign	Het
Snapc4	G	A	2: 26,365,498	Q1005*	probably null	Het
Stag3	A	G	5: 138,298,839	I550M	probably damaging	Het
Steap4	G	T	5: 7,980,494	R450L	probably damaging	Het
Strn4	T	C	7: 16,822,998		probably benign	Het
Stxbp3	C	T	3: 108,805,233		probably null	Het
Syngr1	A	G	15: 80,116,039	D117G	probably damaging	Het
Tbc1d10b	A	T	7: 127,199,795	I513N	possibly damaging	Het

Other mutations in Ceacam14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Ceacam14	APN	7	17814137	missense	probably damaging	1.00
R0452:Ceacam14	UTSW	7	17815323	missense	probably benign
R1613:Ceacam14	UTSW	7	17814048	splice site	probably benign
R1990:Ceacam14	UTSW	7	17815365	nonsense	probably null
R2153:Ceacam14	UTSW	7	17814228	missense	probably benign	0.00
R4724:Ceacam14	UTSW	7	17814050	critical splice acceptor site	probably null
R5323:Ceacam14	UTSW	7	17815477	makesense	probably null
R5454:Ceacam14	UTSW	7	17814185	missense	probably damaging	1.00
R5696:Ceacam14	UTSW	7	17814342	missense	probably damaging	0.97
R6318:Ceacam14	UTSW	7	17814312	missense	probably damaging	1.00
R6763:Ceacam14	UTSW	7	17815343	missense	probably benign	0.04
R7607:Ceacam14	UTSW	7	17814321	missense	possibly damaging	0.95
R7789:Ceacam14	UTSW	7	17814171	missense	probably damaging	0.99
R8946:Ceacam14	UTSW	7	17814074	missense	probably benign	0.01
R9781:Ceacam14	UTSW	7	17815157	missense	possibly damaging	0.60

Predicted Primers

PCR Primer
(F):5'- TGTCAACTCAGGACACAGATC -3'
(R):5'- TTTGCATCAAGTATCCGTAGAGTG -3'

Sequencing Primer
(F):5'- AGGACACAGATCTCATCTTTCC -3'
(R):5'- GTGACACTCTTGATCAGCAGAGATC -3'

Posted On

2015-04-17