Mutagenetix > Incidental Mutation

Incidental Mutation 'R3887:Ceacam14'

309697

Institutional Source

Beutler Lab

Gene Symbol

Ceacam14

Ensembl Gene

ENSMUSG00000023185

Gene Name

CEA cell adhesion molecule 14

Synonyms

1600021E03Rik, 1600025E09Rik

MMRRC Submission

040799-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R3887 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

17546607-17549552 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 17548063 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 51 (V51D)

Ref Sequence

ENSEMBL: ENSMUSP00000023953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023953]

AlphaFold

Q78Y72

Predicted Effect

probably damaging
Transcript: ENSMUST00000023953
AA Change: V51D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000023953
Gene: ENSMUSG00000023185
AA Change: V51D

Domain	Start	End	E-Value	Type
low complexity region	18	29	N/A	INTRINSIC
IG_like	40	141	6.35e0	SMART
IG_like	158	261	2.73e1	SMART

Meta Mutation Damage Score

0.5271

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

100% (40/40)

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933407L21Rik	T	A	1: 85,868,273 (GRCm39)		probably null	Het
Ankdd1a	C	A	9: 65,409,530 (GRCm39)	G469W	probably damaging	Het
Ano6	A	C	15: 95,792,330 (GRCm39)	T65P	possibly damaging	Het
Arhgap26	G	A	18: 39,363,019 (GRCm39)		probably null	Het
Ccdc175	A	G	12: 72,182,822 (GRCm39)	I399T	possibly damaging	Het
Cerk	A	T	15: 86,033,532 (GRCm39)	I297N	possibly damaging	Het
Cps1	C	A	1: 67,204,659 (GRCm39)	T493K	possibly damaging	Het
Dmxl1	T	A	18: 50,011,326 (GRCm39)	M1161K	probably damaging	Het
Efcab14	T	A	4: 115,595,857 (GRCm39)	M1K	probably null	Het
Etl4	C	T	2: 20,534,772 (GRCm39)	Q76*	probably null	Het
Fmc1	T	C	6: 38,516,223 (GRCm39)	S90P	probably benign	Het
Fn1	T	C	1: 71,679,465 (GRCm39)	Y511C	probably damaging	Het
Foxd2	T	C	4: 114,765,483 (GRCm39)	H179R	unknown	Het
Hk2	C	T	6: 82,711,942 (GRCm39)	D548N	possibly damaging	Het
Lct	T	C	1: 128,231,963 (GRCm39)	M629V	probably damaging	Het
Lrp5	G	A	19: 3,662,330 (GRCm39)	R173C	probably damaging	Het
Mapk12	A	T	15: 89,019,840 (GRCm39)	H122Q	possibly damaging	Het
Mdfic	C	T	6: 15,799,710 (GRCm39)	T279I	probably damaging	Het
Mycbp2	A	G	14: 103,412,233 (GRCm39)	V2580A	probably damaging	Het
Mylk3	A	G	8: 86,078,676 (GRCm39)	I476T	probably damaging	Het
Ncapg	G	A	5: 45,831,705 (GRCm39)	V184I	probably benign	Het
Or4a71	T	A	2: 89,358,076 (GRCm39)	H226L	possibly damaging	Het
Pla2g15	A	G	8: 106,887,767 (GRCm39)	Y185C	probably damaging	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Rbm45	A	G	2: 76,205,768 (GRCm39)	S207G	probably benign	Het
Reln	T	C	5: 22,115,847 (GRCm39)	I3054V	possibly damaging	Het
Rreb1	G	T	13: 38,077,941 (GRCm39)	R51L	probably damaging	Het
Scube2	A	T	7: 109,442,383 (GRCm39)		probably benign	Het
Slc15a2	A	G	16: 36,602,666 (GRCm39)	F65S	probably damaging	Het
Slc17a8	G	T	10: 89,427,000 (GRCm39)		probably benign	Het
Snapc4	G	A	2: 26,255,510 (GRCm39)	Q1005*	probably null	Het
Stag3	A	G	5: 138,297,101 (GRCm39)	I550M	probably damaging	Het
Steap4	G	T	5: 8,030,494 (GRCm39)	R450L	probably damaging	Het
Strn4	T	C	7: 16,556,923 (GRCm39)		probably benign	Het
Stxbp3	C	T	3: 108,712,549 (GRCm39)		probably null	Het
Syngr1	A	G	15: 80,000,240 (GRCm39)	D117G	probably damaging	Het
Tbc1d10b	A	T	7: 126,798,967 (GRCm39)	I513N	possibly damaging	Het

Other mutations in Ceacam14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Ceacam14	APN	7	17,548,062 (GRCm39)	missense	probably damaging	1.00
R0452:Ceacam14	UTSW	7	17,549,248 (GRCm39)	missense	probably benign
R1613:Ceacam14	UTSW	7	17,547,973 (GRCm39)	splice site	probably benign
R1990:Ceacam14	UTSW	7	17,549,290 (GRCm39)	nonsense	probably null
R2153:Ceacam14	UTSW	7	17,548,153 (GRCm39)	missense	probably benign	0.00
R4724:Ceacam14	UTSW	7	17,547,975 (GRCm39)	critical splice acceptor site	probably null
R5323:Ceacam14	UTSW	7	17,549,402 (GRCm39)	makesense	probably null
R5454:Ceacam14	UTSW	7	17,548,110 (GRCm39)	missense	probably damaging	1.00
R5696:Ceacam14	UTSW	7	17,548,267 (GRCm39)	missense	probably damaging	0.97
R6318:Ceacam14	UTSW	7	17,548,237 (GRCm39)	missense	probably damaging	1.00
R6763:Ceacam14	UTSW	7	17,549,268 (GRCm39)	missense	probably benign	0.04
R7607:Ceacam14	UTSW	7	17,548,246 (GRCm39)	missense	possibly damaging	0.95
R7789:Ceacam14	UTSW	7	17,548,096 (GRCm39)	missense	probably damaging	0.99
R8946:Ceacam14	UTSW	7	17,547,999 (GRCm39)	missense	probably benign	0.01
R9781:Ceacam14	UTSW	7	17,549,082 (GRCm39)	missense	possibly damaging	0.60

Predicted Primers

PCR Primer
(F):5'- TGTCAACTCAGGACACAGATC -3'
(R):5'- TTTGCATCAAGTATCCGTAGAGTG -3'

Sequencing Primer
(F):5'- AGGACACAGATCTCATCTTTCC -3'
(R):5'- GTGACACTCTTGATCAGCAGAGATC -3'

Posted On

2015-04-17