Incidental Mutation 'R3746:Or51b6'
ID 309808
Institutional Source Beutler Lab
Gene Symbol Or51b6
Ensembl Gene ENSMUSG00000110259
Gene Name olfactory receptor family 51 subfamily B member 6
Synonyms MOR1-2, Olfr65, 5'[b]3, GA_x6K02T2PBJ9-6634906-6633983
MMRRC Submission 040732-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # R3746 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 103555549-103556654 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 103556267 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 207 (M207K)
Ref Sequence ENSEMBL: ENSMUSP00000147914 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106864] [ENSMUST00000209528] [ENSMUST00000214300]
AlphaFold A0A1B0GSF4
Predicted Effect probably benign
Transcript: ENSMUST00000106864
AA Change: M204K

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000102477
Gene: ENSMUSG00000110259
AA Change: M204K

DomainStartEndE-ValueType
Pfam:7tm_4 32 310 2.1e-113 PFAM
Pfam:7TM_GPCR_Srsx 36 300 5.6e-7 PFAM
Pfam:7tm_1 42 293 5.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209528
AA Change: M207K

PolyPhen 2 Score 0.191 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000214300
AA Change: M204K

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Meta Mutation Damage Score 0.4473 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh C A 5: 77,036,501 (GRCm39) E347* probably null Het
Abcb5 T C 12: 118,838,355 (GRCm39) D1069G probably damaging Het
Ago1 A G 4: 126,354,837 (GRCm39) I125T probably benign Het
Ccdc40 T C 11: 119,155,252 (GRCm39) V1164A probably benign Het
Chd7 G A 4: 8,752,537 (GRCm39) V345M probably damaging Het
Cln6 A G 9: 62,754,284 (GRCm39) I109V probably benign Het
Csmd3 A T 15: 47,713,162 (GRCm39) F1604Y probably benign Het
Cx3cr1 T C 9: 119,881,132 (GRCm39) H90R probably damaging Het
Dip2c A T 13: 9,651,509 (GRCm39) D674V probably damaging Het
Dnah17 T C 11: 117,973,742 (GRCm39) S1935G probably benign Het
Eif3g G A 9: 20,805,993 (GRCm39) R295C probably benign Het
Epha5 T C 5: 84,206,963 (GRCm39) K998E probably damaging Het
Fam171b A T 2: 83,709,944 (GRCm39) T539S probably damaging Het
Fer1l4 G T 2: 155,876,968 (GRCm39) H1159N probably benign Het
Fsip1 A G 2: 118,063,531 (GRCm39) C313R probably damaging Het
Gm37240 T G 3: 84,426,919 (GRCm39) N168T probably benign Het
Gm7589 T C 9: 59,053,138 (GRCm39) noncoding transcript Het
Igkv20-101-2 A T 6: 68,451,942 (GRCm39) I66L possibly damaging Het
Irf3 T C 7: 44,648,297 (GRCm39) F54S probably damaging Het
Lrba T G 3: 86,283,260 (GRCm39) L1858R probably damaging Het
Lrp10 A T 14: 54,706,723 (GRCm39) N520I possibly damaging Het
Map3k21 A G 8: 126,661,839 (GRCm39) K479E probably damaging Het
Mpdz A C 4: 81,281,384 (GRCm39) V609G probably damaging Het
Opcml G A 9: 28,812,826 (GRCm39) V173M possibly damaging Het
Osbpl7 T C 11: 96,946,879 (GRCm39) V223A probably damaging Het
Pcdh17 A T 14: 84,770,477 (GRCm39) Y985F probably benign Het
Piezo1 G T 8: 123,219,377 (GRCm39) F1084L probably damaging Het
Pkhd1 A G 1: 20,128,524 (GRCm39) *4060Q probably null Het
Plekhn1 T C 4: 156,310,051 (GRCm39) T88A probably benign Het
Pramel18 T A 4: 101,767,073 (GRCm39) D107E possibly damaging Het
Rmdn2 T A 17: 79,977,981 (GRCm39) probably null Het
Selenom A G 11: 3,467,132 (GRCm39) E137G probably benign Het
Slc38a7 A G 8: 96,570,380 (GRCm39) probably benign Het
Slc39a12 T C 2: 14,400,878 (GRCm39) probably benign Het
Slk T G 19: 47,608,248 (GRCm39) D400E possibly damaging Het
Supt16 A G 14: 52,417,596 (GRCm39) L306P probably damaging Het
Tas2r136 A T 6: 132,754,200 (GRCm39) F309Y probably damaging Het
Tmem63a G A 1: 180,790,679 (GRCm39) D446N possibly damaging Het
Trim63 G A 4: 134,042,665 (GRCm39) C44Y probably damaging Het
Ush2a G A 1: 188,542,489 (GRCm39) G3352S probably benign Het
Vmn1r4 A G 6: 56,934,116 (GRCm39) R207G probably damaging Het
Vmn2r76 A G 7: 85,874,763 (GRCm39) V738A probably benign Het
Vwa5b2 A G 16: 20,417,076 (GRCm39) probably benign Het
Zfhx4 G A 3: 5,308,225 (GRCm39) E484K possibly damaging Het
Other mutations in Or51b6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01079:Or51b6 APN 7 103,555,669 (GRCm39) missense probably benign
IGL02830:Or51b6 APN 7 103,555,651 (GRCm39) missense probably benign 0.32
IGL03238:Or51b6 APN 7 103,555,717 (GRCm39) missense probably benign
R0674:Or51b6 UTSW 7 103,556,462 (GRCm39) missense probably benign 0.01
R1711:Or51b6 UTSW 7 103,555,906 (GRCm39) missense probably damaging 1.00
R2018:Or51b6 UTSW 7 103,556,249 (GRCm39) missense possibly damaging 0.88
R2363:Or51b6 UTSW 7 103,556,267 (GRCm39) missense probably benign 0.19
R2968:Or51b6 UTSW 7 103,556,519 (GRCm39) missense probably benign 0.01
R2970:Or51b6 UTSW 7 103,556,519 (GRCm39) missense probably benign 0.01
R4928:Or51b6 UTSW 7 103,555,879 (GRCm39) missense probably damaging 1.00
R5092:Or51b6 UTSW 7 103,556,406 (GRCm39) nonsense probably null
R5635:Or51b6 UTSW 7 103,555,845 (GRCm39) missense probably benign 0.05
R5881:Or51b6 UTSW 7 103,555,883 (GRCm39) missense probably damaging 0.98
R5963:Or51b6 UTSW 7 103,556,168 (GRCm39) missense probably benign 0.02
R5969:Or51b6 UTSW 7 103,556,117 (GRCm39) missense probably damaging 0.98
R6859:Or51b6 UTSW 7 103,555,908 (GRCm39) nonsense probably null
R7857:Or51b6 UTSW 7 103,555,817 (GRCm39) missense
R8065:Or51b6 UTSW 7 103,555,610 (GRCm39) start gained probably benign
R8067:Or51b6 UTSW 7 103,555,610 (GRCm39) start gained probably benign
R8381:Or51b6 UTSW 7 103,556,146 (GRCm39) missense
R8501:Or51b6 UTSW 7 103,555,818 (GRCm39) missense
R8737:Or51b6 UTSW 7 103,555,913 (GRCm39) missense
R8796:Or51b6 UTSW 7 103,556,201 (GRCm39) missense
R9007:Or51b6 UTSW 7 103,556,165 (GRCm39) missense
R9455:Or51b6 UTSW 7 103,556,200 (GRCm39) missense
R9591:Or51b6 UTSW 7 103,556,470 (GRCm39) missense
X0065:Or51b6 UTSW 7 103,556,423 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGATTGGCATAGGCGTAGTG -3'
(R):5'- CATTGTGATGTGGACGACATGAG -3'

Sequencing Primer
(F):5'- GATGAGGGCTGGTCTGTCAATC -3'
(R):5'- GGACGACATGAGGAACATTCTTTCC -3'
Posted On 2015-04-17