Incidental Mutation 'R3892:Vmn2r75'
ID 309983
Institutional Source Beutler Lab
Gene Symbol Vmn2r75
Ensembl Gene ENSMUSG00000090436
Gene Name vomeronasal 2, receptor 75
Synonyms EG546981
MMRRC Submission 040804-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R3892 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 85797250-85820932 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85813494 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 436 (L436Q)
Ref Sequence ENSEMBL: ENSMUSP00000126973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167830]
AlphaFold G5E8Z7
Predicted Effect probably null
Transcript: ENSMUST00000167830
AA Change: L436Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126973
Gene: ENSMUSG00000090436
AA Change: L436Q

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 80 466 2.8e-31 PFAM
Pfam:NCD3G 510 562 4.6e-20 PFAM
Pfam:7tm_3 593 829 7.7e-51 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 T A 10: 50,718,289 (GRCm39) I1994N probably damaging Het
BC061237 A G 14: 44,738,730 (GRCm39) D43G probably benign Het
Bckdhb A C 9: 83,870,863 (GRCm39) E124D probably damaging Het
Card6 T C 15: 5,128,778 (GRCm39) T873A probably benign Het
Cbs C A 17: 31,835,048 (GRCm39) C476F probably benign Het
Cckbr A C 7: 105,075,376 (GRCm39) T49P probably benign Het
Cd248 C T 19: 5,119,534 (GRCm39) P461S probably damaging Het
Cdh16 T C 8: 105,342,959 (GRCm39) Y19C probably damaging Het
Clip2 T C 5: 134,551,847 (GRCm39) K92E probably damaging Het
Cnnm2 T A 19: 46,750,232 (GRCm39) C7* probably null Het
Ctnnb1 T G 9: 120,779,580 (GRCm39) probably benign Het
Def8 T C 8: 124,185,083 (GRCm39) probably benign Het
Deup1 A G 9: 15,511,009 (GRCm39) Y257H probably damaging Het
Diaph1 C A 18: 38,033,691 (GRCm39) probably benign Het
Dmrta1 A T 4: 89,579,831 (GRCm39) I264F possibly damaging Het
Dnah12 A G 14: 26,578,573 (GRCm39) M491V probably benign Het
Eftud2 A C 11: 102,737,013 (GRCm39) I590S probably damaging Het
Ep300 T C 15: 81,504,198 (GRCm39) probably benign Het
Fam209 A G 2: 172,314,618 (GRCm39) K36E probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Flg A T 3: 93,186,833 (GRCm39) Q95L probably benign Het
Gabrr2 A G 4: 33,081,348 (GRCm39) Y4C probably damaging Het
Ggcx G A 6: 72,395,355 (GRCm39) V149M probably damaging Het
Gm10801 T G 2: 98,494,246 (GRCm39) probably null Het
H2-M10.1 T A 17: 36,635,281 (GRCm39) Q250L possibly damaging Het
Hecw2 A T 1: 53,965,280 (GRCm39) N515K probably benign Het
Hmcn1 A T 1: 150,510,946 (GRCm39) D3592E probably damaging Het
Klf5 T A 14: 99,536,509 (GRCm39) F27I probably benign Het
Krt1 T A 15: 101,758,847 (GRCm39) S106C unknown Het
Lrrc14b T C 13: 74,511,787 (GRCm39) S98G probably benign Het
Lrrc7 A G 3: 157,866,333 (GRCm39) V1136A probably benign Het
Map3k11 G T 19: 5,752,311 (GRCm39) C831F probably benign Het
Mccc2 T C 13: 100,104,241 (GRCm39) T303A probably benign Het
Mipep T C 14: 61,046,444 (GRCm39) L322P probably damaging Het
Mob1b T A 5: 88,901,061 (GRCm39) I156K probably damaging Het
Myd88 T C 9: 119,166,882 (GRCm39) D225G possibly damaging Het
Nos1ap T C 1: 170,177,025 (GRCm39) Y126C probably damaging Het
Nuak2 G T 1: 132,259,223 (GRCm39) A342S possibly damaging Het
Or10ah1-ps1 G T 5: 143,123,152 (GRCm39) S290R probably benign Het
Or4f15 A C 2: 111,813,486 (GRCm39) M311R probably benign Het
Or7e165 T G 9: 19,695,011 (GRCm39) I194S probably benign Het
Pcdhb16 A T 18: 37,612,422 (GRCm39) I461F probably benign Het
Pcdhga10 A C 18: 37,882,534 (GRCm39) H765P probably benign Het
Plxna4 C A 6: 32,192,589 (GRCm39) D791Y probably damaging Het
Pole T G 5: 110,484,305 (GRCm39) I320M probably damaging Het
Psg23 G T 7: 18,345,966 (GRCm39) T243N probably damaging Het
Ptma-ps1 A G 7: 23,763,543 (GRCm39) noncoding transcript Het
Ptprk A T 10: 28,139,617 (GRCm39) Q114L probably benign Het
Pum1 T C 4: 130,491,393 (GRCm39) L774P probably damaging Het
Rabgef1 A G 5: 130,237,520 (GRCm39) probably benign Het
Rasef A G 4: 73,698,634 (GRCm39) V9A probably benign Het
Rcbtb1 T A 14: 59,465,804 (GRCm39) H382Q possibly damaging Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Sacs T G 14: 61,441,836 (GRCm39) I1294R probably damaging Het
Slc19a3 A T 1: 83,000,678 (GRCm39) F113Y probably damaging Het
Snrnp48 G A 13: 38,401,365 (GRCm39) S204N possibly damaging Het
Sp3 A G 2: 72,809,376 (GRCm39) probably benign Het
St8sia6 G A 2: 13,677,335 (GRCm39) H161Y probably benign Het
Strip2 A T 6: 29,917,074 (GRCm39) probably benign Het
Trank1 T C 9: 111,193,827 (GRCm39) V617A probably benign Het
Uvssa T A 5: 33,547,096 (GRCm39) S221T probably benign Het
Wdfy4 T C 14: 32,769,237 (GRCm39) E2076G probably damaging Het
Zfp407 C T 18: 84,578,477 (GRCm39) V879I probably damaging Het
Zmym4 A G 4: 126,798,269 (GRCm39) I786T probably benign Het
Other mutations in Vmn2r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Vmn2r75 APN 7 85,797,240 (GRCm39) unclassified probably benign
IGL01287:Vmn2r75 APN 7 85,797,801 (GRCm39) missense probably damaging 0.97
IGL01318:Vmn2r75 APN 7 85,814,774 (GRCm39) missense probably benign 0.06
IGL01331:Vmn2r75 APN 7 85,820,870 (GRCm39) nonsense probably null
IGL01406:Vmn2r75 APN 7 85,812,500 (GRCm39) splice site probably benign
IGL01615:Vmn2r75 APN 7 85,797,681 (GRCm39) missense probably benign 0.03
IGL01657:Vmn2r75 APN 7 85,813,455 (GRCm39) missense probably damaging 1.00
IGL02237:Vmn2r75 APN 7 85,814,786 (GRCm39) missense possibly damaging 0.88
IGL02275:Vmn2r75 APN 7 85,814,348 (GRCm39) missense probably benign 0.04
IGL02307:Vmn2r75 APN 7 85,814,974 (GRCm39) missense probably benign 0.00
IGL03136:Vmn2r75 APN 7 85,797,911 (GRCm39) missense possibly damaging 0.89
IGL03160:Vmn2r75 APN 7 85,797,644 (GRCm39) missense probably damaging 1.00
IGL03244:Vmn2r75 APN 7 85,820,933 (GRCm39) unclassified probably benign
PIT4449001:Vmn2r75 UTSW 7 85,814,791 (GRCm39) missense probably damaging 1.00
R0049:Vmn2r75 UTSW 7 85,797,309 (GRCm39) nonsense probably null
R0049:Vmn2r75 UTSW 7 85,797,309 (GRCm39) nonsense probably null
R0083:Vmn2r75 UTSW 7 85,814,866 (GRCm39) missense probably benign 0.00
R0108:Vmn2r75 UTSW 7 85,814,866 (GRCm39) missense probably benign 0.00
R0276:Vmn2r75 UTSW 7 85,797,515 (GRCm39) missense probably benign 0.01
R0320:Vmn2r75 UTSW 7 85,814,288 (GRCm39) missense probably benign 0.36
R0471:Vmn2r75 UTSW 7 85,814,721 (GRCm39) missense probably benign 0.01
R0562:Vmn2r75 UTSW 7 85,797,449 (GRCm39) nonsense probably null
R0631:Vmn2r75 UTSW 7 85,812,478 (GRCm39) missense probably null 1.00
R0661:Vmn2r75 UTSW 7 85,814,866 (GRCm39) missense probably benign 0.00
R0811:Vmn2r75 UTSW 7 85,814,575 (GRCm39) missense probably benign 0.38
R0812:Vmn2r75 UTSW 7 85,814,575 (GRCm39) missense probably benign 0.38
R0891:Vmn2r75 UTSW 7 85,813,476 (GRCm39) missense possibly damaging 0.81
R1340:Vmn2r75 UTSW 7 85,797,798 (GRCm39) missense probably damaging 0.98
R1501:Vmn2r75 UTSW 7 85,814,850 (GRCm39) missense possibly damaging 0.85
R1760:Vmn2r75 UTSW 7 85,798,019 (GRCm39) missense probably damaging 1.00
R1970:Vmn2r75 UTSW 7 85,797,470 (GRCm39) missense probably damaging 1.00
R2060:Vmn2r75 UTSW 7 85,814,372 (GRCm39) missense probably benign 0.00
R2292:Vmn2r75 UTSW 7 85,798,144 (GRCm39) missense probably damaging 1.00
R3688:Vmn2r75 UTSW 7 85,797,629 (GRCm39) missense probably damaging 0.99
R4532:Vmn2r75 UTSW 7 85,797,349 (GRCm39) nonsense probably null
R4583:Vmn2r75 UTSW 7 85,813,290 (GRCm39) missense possibly damaging 0.81
R4592:Vmn2r75 UTSW 7 85,815,494 (GRCm39) missense probably benign 0.00
R4792:Vmn2r75 UTSW 7 85,812,378 (GRCm39) missense possibly damaging 0.46
R4859:Vmn2r75 UTSW 7 85,797,611 (GRCm39) missense probably benign 0.35
R4896:Vmn2r75 UTSW 7 85,820,787 (GRCm39) missense probably benign 0.01
R4943:Vmn2r75 UTSW 7 85,814,705 (GRCm39) missense probably damaging 1.00
R4992:Vmn2r75 UTSW 7 85,815,375 (GRCm39) critical splice donor site probably null
R5048:Vmn2r75 UTSW 7 85,814,735 (GRCm39) missense possibly damaging 0.66
R5063:Vmn2r75 UTSW 7 85,813,372 (GRCm39) missense probably benign
R5156:Vmn2r75 UTSW 7 85,813,436 (GRCm39) missense possibly damaging 0.51
R5243:Vmn2r75 UTSW 7 85,813,447 (GRCm39) missense probably damaging 1.00
R5277:Vmn2r75 UTSW 7 85,815,500 (GRCm39) missense probably benign
R5574:Vmn2r75 UTSW 7 85,815,510 (GRCm39) missense probably benign 0.22
R5622:Vmn2r75 UTSW 7 85,797,702 (GRCm39) missense probably benign 0.15
R5680:Vmn2r75 UTSW 7 85,820,779 (GRCm39) missense probably benign 0.10
R5884:Vmn2r75 UTSW 7 85,814,578 (GRCm39) missense probably benign
R6021:Vmn2r75 UTSW 7 85,820,820 (GRCm39) missense probably benign 0.01
R6217:Vmn2r75 UTSW 7 85,815,375 (GRCm39) critical splice donor site probably benign
R6242:Vmn2r75 UTSW 7 85,814,592 (GRCm39) missense probably damaging 1.00
R6299:Vmn2r75 UTSW 7 85,814,482 (GRCm39) missense probably benign 0.12
R6441:Vmn2r75 UTSW 7 85,820,784 (GRCm39) missense probably damaging 0.99
R6495:Vmn2r75 UTSW 7 85,813,287 (GRCm39) missense probably benign 0.00
R6553:Vmn2r75 UTSW 7 85,813,453 (GRCm39) missense probably benign 0.28
R6670:Vmn2r75 UTSW 7 85,797,644 (GRCm39) missense probably damaging 1.00
R7078:Vmn2r75 UTSW 7 85,815,568 (GRCm39) missense probably damaging 1.00
R7164:Vmn2r75 UTSW 7 85,814,592 (GRCm39) missense probably damaging 1.00
R8411:Vmn2r75 UTSW 7 85,797,722 (GRCm39) missense probably damaging 1.00
R8507:Vmn2r75 UTSW 7 85,797,685 (GRCm39) nonsense probably null
R8559:Vmn2r75 UTSW 7 85,815,480 (GRCm39) missense possibly damaging 0.65
R8677:Vmn2r75 UTSW 7 85,814,410 (GRCm39) missense possibly damaging 0.86
R8708:Vmn2r75 UTSW 7 85,812,476 (GRCm39) missense probably damaging 0.99
R8778:Vmn2r75 UTSW 7 85,813,497 (GRCm39) missense probably benign 0.40
R8968:Vmn2r75 UTSW 7 85,820,765 (GRCm39) nonsense probably null
R9145:Vmn2r75 UTSW 7 85,813,447 (GRCm39) missense probably damaging 1.00
R9316:Vmn2r75 UTSW 7 85,797,313 (GRCm39) missense possibly damaging 0.63
R9363:Vmn2r75 UTSW 7 85,815,423 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- ATAGCTGTTGACCACTTGGAAG -3'
(R):5'- CCTGTGATCAAATAACACTATTGGC -3'

Sequencing Primer
(F):5'- GCTGTTGACCACTTGGAAGATAACC -3'
(R):5'- CACTATTGGCAGTTAAAACACAGAG -3'
Posted On 2015-04-17