Mutagenetix > Incidental Mutations

Incidental Mutation 'R0382:Vmn2r9'

31009

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

MMRRC Submission

038588-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.123) question?

Stock #

R0382 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

108842947-108852510 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108847597 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 395 (Y395C)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

Predicted Effect

probably damaging
Transcript: ENSMUST00000170419
AA Change: Y395C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: Y395C

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176157

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.5%
20x: 90.1%

Validation Efficiency

98% (58/59)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	A	T	6: 86,946,919	Q266L	probably benign	Het
Abca13	T	C	11: 9,636,650		probably benign	Het
Adap2	T	C	11: 80,178,385		probably benign	Het
Adgrb2	C	G	4: 130,007,831	P416R	probably damaging	Het
Brinp1	T	C	4: 68,762,308	R662G	possibly damaging	Het
Celsr3	C	A	9: 108,829,218	P967T	probably damaging	Het
Ces1b	T	C	8: 93,076,052		probably benign	Het
Ckm	T	C	7: 19,421,384	*382Q	probably null	Het
Clec14a	A	G	12: 58,268,617	V73A	probably damaging	Het
Cmya5	A	T	13: 93,092,748	V1944E	probably benign	Het
Col6a6	T	A	9: 105,755,555	D1473V	probably damaging	Het
Cttnbp2	A	G	6: 18,435,343	M172T	probably benign	Het
Dcaf12	T	C	4: 41,302,672	N161S	probably damaging	Het
Dnah17	T	C	11: 118,128,996	Y75C	probably damaging	Het
Efcab7	T	C	4: 99,901,769	V388A	possibly damaging	Het
Fat3	A	G	9: 15,959,756	C3780R	probably damaging	Het
Fbxl14	T	C	6: 119,481,060	*401R	probably null	Het
Fbxo5	G	T	10: 5,801,176	Y270*	probably null	Het
Fnbp1l	A	T	3: 122,570,953		probably benign	Het
Fstl3	T	C	10: 79,777,307	S3P	probably benign	Het
Gpatch1	T	C	7: 35,301,655	D309G	probably damaging	Het
Gstcd	A	T	3: 132,986,408	L582H	probably damaging	Het
Klk6	A	G	7: 43,829,245	D192G	probably benign	Het
Lrp6	A	G	6: 134,467,668	S1080P	probably damaging	Het
Lztfl1	T	C	9: 123,707,906		probably null	Het
Mov10l1	A	G	15: 88,985,593	Y59C	possibly damaging	Het
Natd1	C	T	11: 60,906,913	R62H	probably damaging	Het
Obscn	T	C	11: 59,040,306	T5835A	probably damaging	Het
Olfr1052	A	G	2: 86,298,593	Y259C	probably damaging	Het
Olfr1183	A	T	2: 88,461,725	R147S	possibly damaging	Het
Olfr1354	T	A	10: 78,917,126	Y95*	probably null	Het
Olfr792	T	C	10: 129,541,014	I159T	probably benign	Het
P2rx2	T	A	5: 110,341,179	E289V	probably benign	Het
Patl1	T	A	19: 11,925,232		probably null	Het
Ptprf	A	G	4: 118,223,394		probably benign	Het
Qrfpr	C	T	3: 36,180,969	C253Y	possibly damaging	Het
Rad21l	A	T	2: 151,645,443	D540E	probably damaging	Het
Rbm45	T	A	2: 76,370,211	I28N	possibly damaging	Het
Rnf170	A	T	8: 26,125,899		probably benign	Het
Sgsm3	G	A	15: 81,008,314	W280*	probably null	Het
Slc9a9	A	T	9: 94,685,217	H113L	probably benign	Het
Slc9b2	G	T	3: 135,318,422	C78F	probably damaging	Het
Slfn10-ps	T	A	11: 83,029,534		noncoding transcript	Het
Slfn8	T	A	11: 83,004,556	I475F	probably damaging	Het
Stox2	A	G	8: 47,203,284		probably benign	Het
Strbp	A	T	2: 37,600,826	N472K	probably benign	Het
Tcam1	G	A	11: 106,284,078	E120K	probably benign	Het
Tmem39a	A	G	16: 38,591,398		probably benign	Het
Trpc4ap	A	G	2: 155,636,230	L664P	probably damaging	Het
Uap1	T	A	1: 170,161,482	M124L	probably benign	Het
Usp48	A	G	4: 137,621,218	N536S	probably benign	Het
Usp50	T	A	2: 126,777,928	I155F	probably damaging	Het
Utp4	T	C	8: 106,922,935	I672T	probably benign	Het
Vmn1r94	A	T	7: 20,167,653	M242K	possibly damaging	Het
Vmn2r45	T	G	7: 8,483,099	N397H	probably benign	Het
Vps41	C	A	13: 18,827,727	H335N	probably benign	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108848024	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108849037	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108842945	unclassified	probably null
IGL01892:Vmn2r9	APN	5	108847834	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108847567	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108843636	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108842984	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108848201	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108842990	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108848307	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108847954	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108848131	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108843125	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108847539	missense	probably benign	0.11
R0521:Vmn2r9	UTSW	5	108848288	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108843303	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108847574	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108848984	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108843828	missense	probably benign
R1469:Vmn2r9	UTSW	5	108843828	missense	probably benign
R1704:Vmn2r9	UTSW	5	108846400	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108847522	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108846439	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108848257	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108846433	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108848131	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108847835	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108847919	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108847919	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108849055	missense	probably benign
R4156:Vmn2r9	UTSW	5	108847877	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108846277	missense	probably benign
R4478:Vmn2r9	UTSW	5	108846277	missense	probably benign
R4544:Vmn2r9	UTSW	5	108847685	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108847685	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108847597	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108846485	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108848063	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108847561	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108848260	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108845036	missense	probably benign
R6125:Vmn2r9	UTSW	5	108842970	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108849016	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108849046	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108845082	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGTCTCCTATCAAATGTGATCCTTGTGC -3'
(R):5'- CGGGACTGTTACTTTTGAACACCACC -3'

Sequencing Primer
(F):5'- CCGTGCTAAAGATTCATTAGGG -3'
(R):5'- TTACTTTTGAACACCACCACAGTG -3'

Posted On

2013-04-24