Incidental Mutation 'R3907:Or6z7'
ID 310247
Institutional Source Beutler Lab
Gene Symbol Or6z7
Ensembl Gene ENSMUSG00000096228
Gene Name olfactory receptor family 6 subfamily Z member 7
Synonyms MOR103-8, Olfr5, GA_x6K02T2QGBW-3210997-3210059
MMRRC Submission 040908-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R3907 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 6483215-6490013 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 6483678 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 159 (V159D)
Ref Sequence ENSEMBL: ENSMUSP00000147586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086318] [ENSMUST00000207658] [ENSMUST00000209866] [ENSMUST00000215302]
AlphaFold Q60889
Predicted Effect probably damaging
Transcript: ENSMUST00000086318
AA Change: V159D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000083498
Gene: ENSMUSG00000096228
AA Change: V159D

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.1e-50 PFAM
Pfam:7tm_1 45 294 6.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207658
Predicted Effect probably damaging
Transcript: ENSMUST00000209866
AA Change: V159D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably benign
Transcript: ENSMUST00000215302
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency 97% (56/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 C A 5: 90,009,214 (GRCm39) G150C probably damaging Het
Ampd3 A G 7: 110,392,877 (GRCm39) D215G possibly damaging Het
Ank2 A G 3: 126,810,547 (GRCm39) L513P probably damaging Het
Apba1 T C 19: 23,914,870 (GRCm39) I690T probably damaging Het
Arid1a T C 4: 133,420,223 (GRCm39) probably benign Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Asns C T 6: 7,682,270 (GRCm39) probably null Het
Aspg T A 12: 112,078,693 (GRCm39) Y57* probably null Het
Asph T C 4: 9,474,934 (GRCm39) K680R probably benign Het
Atp2b4 A T 1: 133,666,324 (GRCm39) S243T probably damaging Het
Cacna1s T A 1: 136,012,007 (GRCm39) M483K probably damaging Het
Car4 G A 11: 84,855,183 (GRCm39) V141M probably damaging Het
Cct4 A G 11: 22,951,560 (GRCm39) I376V probably benign Het
Chrm4 C T 2: 91,758,084 (GRCm39) A164V probably damaging Het
Csf3r A T 4: 125,928,240 (GRCm39) D291V probably benign Het
Dcaf6 A T 1: 165,251,949 (GRCm39) C58* probably null Het
Ddi2 T C 4: 141,411,592 (GRCm39) D440G probably benign Het
Defb4 A T 8: 19,251,277 (GRCm39) Q48L possibly damaging Het
Dnaaf9 C T 2: 130,578,496 (GRCm39) A663T probably damaging Het
Duox2 C T 2: 122,113,541 (GRCm39) probably null Het
E130308A19Rik C T 4: 59,752,393 (GRCm39) T502I probably benign Het
Ephb1 A G 9: 101,878,925 (GRCm39) C522R probably benign Het
Fam76a T C 4: 132,643,432 (GRCm39) K101E probably damaging Het
Fat1 G C 8: 45,476,072 (GRCm39) R1706T probably benign Het
Fn1 C T 1: 71,647,072 (GRCm39) G1482R probably damaging Het
Gm10110 T C 14: 90,135,583 (GRCm39) noncoding transcript Het
Gphn T A 12: 78,540,716 (GRCm39) probably benign Het
Hars1 A T 18: 36,915,769 (GRCm39) D48E probably benign Het
Hmgcll1 G A 9: 75,979,943 (GRCm39) R111H probably benign Het
Ighv3-4 A G 12: 114,217,538 (GRCm39) S18P probably damaging Het
Iws1 G A 18: 32,212,973 (GRCm39) E134K possibly damaging Het
Kcnj4 G T 15: 79,369,946 (GRCm39) H11Q probably benign Het
Krt16 A G 11: 100,137,989 (GRCm39) V329A possibly damaging Het
Loxhd1 A T 18: 77,496,464 (GRCm39) M1575L possibly damaging Het
Mapkapk2 A T 1: 130,984,651 (GRCm39) S234T probably damaging Het
Mxd1 G T 6: 86,627,942 (GRCm39) Q199K probably benign Het
Nlrp5 T A 7: 23,133,071 (GRCm39) D905E possibly damaging Het
Or4c117 A C 2: 88,955,927 (GRCm39) Y49* probably null Het
Otoa A T 7: 120,724,788 (GRCm39) Q489L probably damaging Het
Pced1b T C 15: 97,282,431 (GRCm39) S157P probably damaging Het
Ppp1r16b T C 2: 158,603,410 (GRCm39) I345T probably benign Het
Prrt4 G T 6: 29,177,173 (GRCm39) L199M probably damaging Het
Ptpn6 T C 6: 124,702,239 (GRCm39) D347G possibly damaging Het
Pwwp3a T C 10: 80,074,150 (GRCm39) V401A probably damaging Het
Rcan1 A G 16: 92,262,917 (GRCm39) probably benign Het
Rif1 C T 2: 52,002,557 (GRCm39) L2004F probably benign Het
Rnf185 A G 11: 3,376,681 (GRCm39) probably benign Het
Shank2 C T 7: 143,963,313 (GRCm39) P307L probably damaging Het
Slc19a3 G A 1: 82,992,534 (GRCm39) R396C possibly damaging Het
Stn1 T C 19: 47,496,262 (GRCm39) D321G probably damaging Het
Taar7a T C 10: 23,868,457 (GRCm39) Y308C probably benign Het
Tespa1 T C 10: 130,192,666 (GRCm39) probably benign Het
Tmcc2 T C 1: 132,288,376 (GRCm39) D359G probably damaging Het
Trhde C T 10: 114,636,601 (GRCm39) G202E possibly damaging Het
Trip12 T C 1: 84,709,827 (GRCm39) T469A possibly damaging Het
Trip4 A G 9: 65,740,708 (GRCm39) I533T probably benign Het
Tsc22d1 T C 14: 76,653,983 (GRCm39) I154T probably damaging Het
Ttn C A 2: 76,733,686 (GRCm39) probably benign Het
Ugt8a T C 3: 125,708,631 (GRCm39) T160A possibly damaging Het
Usp54 A T 14: 20,636,181 (GRCm39) S288T probably damaging Het
Utrn C T 10: 12,585,926 (GRCm39) probably benign Het
Other mutations in Or6z7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01336:Or6z7 APN 7 6,483,997 (GRCm39) missense probably benign
IGL02174:Or6z7 APN 7 6,483,438 (GRCm39) missense probably benign
IGL03260:Or6z7 APN 7 6,483,658 (GRCm39) missense probably damaging 0.99
IGL03411:Or6z7 APN 7 6,483,435 (GRCm39) missense probably benign 0.26
R1186:Or6z7 UTSW 7 6,483,541 (GRCm39) missense probably benign 0.00
R1381:Or6z7 UTSW 7 6,484,008 (GRCm39) splice site probably null
R1981:Or6z7 UTSW 7 6,483,931 (GRCm39) missense probably benign 0.29
R1982:Or6z7 UTSW 7 6,483,931 (GRCm39) missense probably benign 0.29
R3876:Or6z7 UTSW 7 6,484,131 (GRCm39) missense probably benign 0.01
R4422:Or6z7 UTSW 7 6,484,037 (GRCm39) nonsense probably null
R4654:Or6z7 UTSW 7 6,484,045 (GRCm39) missense probably benign 0.00
R5605:Or6z7 UTSW 7 6,483,325 (GRCm39) missense probably benign 0.00
R6962:Or6z7 UTSW 7 6,484,008 (GRCm39) missense probably benign 0.07
R7524:Or6z7 UTSW 7 6,483,586 (GRCm39) missense probably benign 0.04
R7576:Or6z7 UTSW 7 6,483,330 (GRCm39) missense probably damaging 0.97
R8306:Or6z7 UTSW 7 6,483,868 (GRCm39) missense possibly damaging 0.83
R8947:Or6z7 UTSW 7 6,483,246 (GRCm39) missense probably benign
R8967:Or6z7 UTSW 7 6,484,011 (GRCm39) missense possibly damaging 0.95
R9562:Or6z7 UTSW 7 6,483,243 (GRCm39) missense probably null 0.60
Z1177:Or6z7 UTSW 7 6,483,872 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CATAGTCGTGAGGAAGCAACC -3'
(R):5'- CATGGGGCTATGGAATGGACTC -3'

Sequencing Primer
(F):5'- CCCCAAAGGATGACAATGGCTG -3'
(R):5'- TCATAGCTTGTATGACCCAACTC -3'
Posted On 2015-04-17