Incidental Mutation 'R3894:Ifi204'
| ID |
310429 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ifi204
|
| Ensembl Gene |
ENSMUSG00000073489 |
| Gene Name |
interferon activated gene 204 |
| Synonyms |
p204 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
R3894 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
173574859-173594509 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 173576774 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 609
(H609R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106845
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000111214]
|
| AlphaFold |
P0DOV2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000111214
AA Change: H609R
PolyPhen 2
Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000106845
Gene: ENSMUSG00000073489
AA Change: H609R
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
6 |
84 |
8.33e-14 |
SMART |
|
low complexity region
|
120 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
190 |
206 |
N/A |
INTRINSIC |
|
Pfam:HIN
|
225 |
393 |
6.2e-78 |
PFAM |
|
Pfam:HIN
|
429 |
595 |
9.8e-78 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 45 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akt1s1 |
A |
G |
7: 44,503,363 (GRCm39) |
D180G |
probably damaging |
Het |
| Aldh1a7 |
A |
T |
19: 20,673,762 (GRCm39) |
Y457* |
probably null |
Het |
| Alpk3 |
C |
T |
7: 80,728,138 (GRCm39) |
P423S |
possibly damaging |
Het |
| Aox1 |
A |
T |
1: 58,373,837 (GRCm39) |
|
probably null |
Het |
| Crebbp |
T |
C |
16: 3,913,966 (GRCm39) |
T1316A |
probably benign |
Het |
| Cul3 |
C |
A |
1: 80,261,407 (GRCm39) |
V273F |
probably damaging |
Het |
| Dnah1 |
G |
T |
14: 31,028,985 (GRCm39) |
R582S |
probably benign |
Het |
| Fbxl2 |
T |
C |
9: 113,832,261 (GRCm39) |
N51S |
probably damaging |
Het |
| Gapvd1 |
T |
C |
2: 34,618,488 (GRCm39) |
D295G |
probably benign |
Het |
| Gdf7 |
A |
G |
12: 8,348,845 (GRCm39) |
S151P |
unknown |
Het |
| Gm10277 |
T |
C |
11: 77,676,827 (GRCm39) |
|
probably benign |
Het |
| Hdac4 |
T |
C |
1: 91,898,690 (GRCm39) |
E688G |
possibly damaging |
Het |
| Htr1d |
A |
G |
4: 136,170,548 (GRCm39) |
E259G |
probably benign |
Het |
| Ift80 |
T |
C |
3: 68,825,332 (GRCm39) |
D541G |
probably damaging |
Het |
| Il18r1 |
A |
T |
1: 40,514,034 (GRCm39) |
H80L |
possibly damaging |
Het |
| Lrp4 |
G |
A |
2: 91,304,294 (GRCm39) |
G158S |
probably damaging |
Het |
| Mesd |
T |
A |
7: 83,546,993 (GRCm39) |
L152H |
probably damaging |
Het |
| Mmut |
G |
A |
17: 41,266,030 (GRCm39) |
C531Y |
probably damaging |
Het |
| Morf4l1 |
A |
T |
9: 89,976,501 (GRCm39) |
F276I |
possibly damaging |
Het |
| Mslnl |
G |
A |
17: 25,961,908 (GRCm39) |
V128M |
probably damaging |
Het |
| Myo15a |
A |
G |
11: 60,395,145 (GRCm39) |
T2480A |
probably benign |
Het |
| Or2a52 |
A |
T |
6: 43,144,192 (GRCm39) |
I67F |
probably benign |
Het |
| Or2y15 |
G |
A |
11: 49,350,766 (GRCm39) |
G87R |
possibly damaging |
Het |
| Or4f47 |
T |
C |
2: 111,972,359 (GRCm39) |
I23T |
probably benign |
Het |
| Or4g17 |
C |
A |
2: 111,209,982 (GRCm39) |
F212L |
probably benign |
Het |
| Or5k16 |
A |
G |
16: 58,736,702 (GRCm39) |
F101L |
probably benign |
Het |
| Ovgp1 |
T |
C |
3: 105,893,883 (GRCm39) |
|
probably benign |
Het |
| Ovgp1 |
A |
G |
3: 105,893,912 (GRCm39) |
|
probably benign |
Het |
| Pcbp4 |
A |
T |
9: 106,338,570 (GRCm39) |
Q59L |
possibly damaging |
Het |
| Prg4 |
G |
C |
1: 150,330,510 (GRCm39) |
|
probably benign |
Het |
| Rad50 |
T |
A |
11: 53,569,697 (GRCm39) |
I905L |
probably benign |
Het |
| Rp1l1 |
T |
C |
14: 64,266,756 (GRCm39) |
S781P |
probably benign |
Het |
| Rps3 |
C |
T |
7: 99,129,103 (GRCm39) |
R173H |
probably benign |
Het |
| Rtn3 |
T |
A |
19: 7,412,450 (GRCm39) |
T86S |
probably damaging |
Het |
| Sdha |
A |
T |
13: 74,482,510 (GRCm39) |
S268T |
probably benign |
Het |
| Sgo2b |
A |
T |
8: 64,381,767 (GRCm39) |
V355E |
possibly damaging |
Het |
| Sh3glb2 |
T |
C |
2: 30,245,300 (GRCm39) |
T60A |
probably damaging |
Het |
| Slc26a3 |
A |
C |
12: 31,514,719 (GRCm39) |
Y513S |
probably damaging |
Het |
| Slc35b2 |
T |
C |
17: 45,877,368 (GRCm39) |
V165A |
probably benign |
Het |
| Slco3a1 |
A |
G |
7: 73,934,361 (GRCm39) |
W604R |
probably damaging |
Het |
| Tet2 |
A |
G |
3: 133,175,238 (GRCm39) |
S1370P |
possibly damaging |
Het |
| Tmtc4 |
A |
T |
14: 123,158,731 (GRCm39) |
|
probably null |
Het |
| Tsga13 |
A |
G |
6: 30,889,198 (GRCm39) |
V18A |
probably benign |
Het |
| Ugt2a3 |
T |
C |
5: 87,477,449 (GRCm39) |
T317A |
probably benign |
Het |
| Zcchc4 |
A |
T |
5: 52,941,442 (GRCm39) |
D79V |
probably damaging |
Het |
|
| Other mutations in Ifi204 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00906:Ifi204
|
APN |
1 |
173,587,197 (GRCm39) |
splice site |
probably benign |
|
|
IGL01922:Ifi204
|
APN |
1 |
173,589,288 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02296:Ifi204
|
APN |
1 |
173,576,880 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02419:Ifi204
|
APN |
1 |
173,576,946 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02505:Ifi204
|
APN |
1 |
173,583,220 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0938:Ifi204
|
UTSW |
1 |
173,579,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1363:Ifi204
|
UTSW |
1 |
173,576,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1834:Ifi204
|
UTSW |
1 |
173,575,172 (GRCm39) |
missense |
unknown |
|
|
R2031:Ifi204
|
UTSW |
1 |
173,580,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2254:Ifi204
|
UTSW |
1 |
173,589,296 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2379:Ifi204
|
UTSW |
1 |
173,583,559 (GRCm39) |
nonsense |
probably null |
|
|
R2408:Ifi204
|
UTSW |
1 |
173,583,198 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3011:Ifi204
|
UTSW |
1 |
173,579,217 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3617:Ifi204
|
UTSW |
1 |
173,583,283 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R3916:Ifi204
|
UTSW |
1 |
173,583,341 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4656:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4657:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4694:Ifi204
|
UTSW |
1 |
173,576,825 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4703:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4704:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4894:Ifi204
|
UTSW |
1 |
173,587,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4947:Ifi204
|
UTSW |
1 |
173,583,316 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5023:Ifi204
|
UTSW |
1 |
173,579,306 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5036:Ifi204
|
UTSW |
1 |
173,580,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5119:Ifi204
|
UTSW |
1 |
173,583,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5194:Ifi204
|
UTSW |
1 |
173,576,910 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5762:Ifi204
|
UTSW |
1 |
173,580,325 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6063:Ifi204
|
UTSW |
1 |
173,579,223 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6808:Ifi204
|
UTSW |
1 |
173,589,269 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7311:Ifi204
|
UTSW |
1 |
173,587,134 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7338:Ifi204
|
UTSW |
1 |
173,587,703 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7430:Ifi204
|
UTSW |
1 |
173,583,247 (GRCm39) |
missense |
probably benign |
0.43 |
|
R7528:Ifi204
|
UTSW |
1 |
173,579,406 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7985:Ifi204
|
UTSW |
1 |
173,587,772 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8021:Ifi204
|
UTSW |
1 |
173,586,919 (GRCm39) |
intron |
probably benign |
|
|
R8137:Ifi204
|
UTSW |
1 |
173,589,188 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8141:Ifi204
|
UTSW |
1 |
173,583,189 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8191:Ifi204
|
UTSW |
1 |
173,579,226 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8487:Ifi204
|
UTSW |
1 |
173,587,839 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9075:Ifi204
|
UTSW |
1 |
173,589,282 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9124:Ifi204
|
UTSW |
1 |
173,579,193 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9311:Ifi204
|
UTSW |
1 |
173,589,215 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9498:Ifi204
|
UTSW |
1 |
173,583,537 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9712:Ifi204
|
UTSW |
1 |
173,576,924 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Ifi204
|
UTSW |
1 |
173,579,194 (GRCm39) |
missense |
probably null |
0.00 |
|
| Predicted Primers |
|
| Posted On |
2015-04-17 |
Incidental Mutation