Mutagenetix > Incidental Mutation

Incidental Mutation 'R3894:Or4g17'

310433

Institutional Source

Beutler Lab

Gene Symbol

Or4g17

Ensembl Gene

ENSMUSG00000108931

Gene Name

olfactory receptor family 4 subfamily G member 17

Synonyms

GA_x6K02T2Q125-72430580-72431515, MOR245-13, Olfr1284

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.186) question?

Stock #

R3894 (G1)

Quality Score

224

Status

Not validated

Chromosome

Chromosomal Location

111209347-111210282 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 111209982 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 212 (F212L)

Ref Sequence

ENSEMBL: ENSMUSP00000147014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062407] [ENSMUST00000209096]

AlphaFold

Q8VF29

Predicted Effect

probably benign
Transcript: ENSMUST00000062407
AA Change: F212L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000052153
Gene: ENSMUSG00000108931
AA Change: F212L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	7.2e-45	PFAM
Pfam:7TM_GPCR_Srsx	34	302	2.4e-5	PFAM
Pfam:7tm_1	41	287	2e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000209096
AA Change: F212L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akt1s1	A	G	7: 44,503,363 (GRCm39)	D180G	probably damaging	Het
Aldh1a7	A	T	19: 20,673,762 (GRCm39)	Y457*	probably null	Het
Alpk3	C	T	7: 80,728,138 (GRCm39)	P423S	possibly damaging	Het
Aox1	A	T	1: 58,373,837 (GRCm39)		probably null	Het
Crebbp	T	C	16: 3,913,966 (GRCm39)	T1316A	probably benign	Het
Cul3	C	A	1: 80,261,407 (GRCm39)	V273F	probably damaging	Het
Dnah1	G	T	14: 31,028,985 (GRCm39)	R582S	probably benign	Het
Fbxl2	T	C	9: 113,832,261 (GRCm39)	N51S	probably damaging	Het
Gapvd1	T	C	2: 34,618,488 (GRCm39)	D295G	probably benign	Het
Gdf7	A	G	12: 8,348,845 (GRCm39)	S151P	unknown	Het
Gm10277	T	C	11: 77,676,827 (GRCm39)		probably benign	Het
Hdac4	T	C	1: 91,898,690 (GRCm39)	E688G	possibly damaging	Het
Htr1d	A	G	4: 136,170,548 (GRCm39)	E259G	probably benign	Het
Ifi204	T	C	1: 173,576,774 (GRCm39)	H609R	possibly damaging	Het
Ift80	T	C	3: 68,825,332 (GRCm39)	D541G	probably damaging	Het
Il18r1	A	T	1: 40,514,034 (GRCm39)	H80L	possibly damaging	Het
Lrp4	G	A	2: 91,304,294 (GRCm39)	G158S	probably damaging	Het
Mesd	T	A	7: 83,546,993 (GRCm39)	L152H	probably damaging	Het
Mmut	G	A	17: 41,266,030 (GRCm39)	C531Y	probably damaging	Het
Morf4l1	A	T	9: 89,976,501 (GRCm39)	F276I	possibly damaging	Het
Mslnl	G	A	17: 25,961,908 (GRCm39)	V128M	probably damaging	Het
Myo15a	A	G	11: 60,395,145 (GRCm39)	T2480A	probably benign	Het
Or2a52	A	T	6: 43,144,192 (GRCm39)	I67F	probably benign	Het
Or2y15	G	A	11: 49,350,766 (GRCm39)	G87R	possibly damaging	Het
Or4f47	T	C	2: 111,972,359 (GRCm39)	I23T	probably benign	Het
Or5k16	A	G	16: 58,736,702 (GRCm39)	F101L	probably benign	Het
Ovgp1	T	C	3: 105,893,883 (GRCm39)		probably benign	Het
Ovgp1	A	G	3: 105,893,912 (GRCm39)		probably benign	Het
Pcbp4	A	T	9: 106,338,570 (GRCm39)	Q59L	possibly damaging	Het
Prg4	G	C	1: 150,330,510 (GRCm39)		probably benign	Het
Rad50	T	A	11: 53,569,697 (GRCm39)	I905L	probably benign	Het
Rp1l1	T	C	14: 64,266,756 (GRCm39)	S781P	probably benign	Het
Rps3	C	T	7: 99,129,103 (GRCm39)	R173H	probably benign	Het
Rtn3	T	A	19: 7,412,450 (GRCm39)	T86S	probably damaging	Het
Sdha	A	T	13: 74,482,510 (GRCm39)	S268T	probably benign	Het
Sgo2b	A	T	8: 64,381,767 (GRCm39)	V355E	possibly damaging	Het
Sh3glb2	T	C	2: 30,245,300 (GRCm39)	T60A	probably damaging	Het
Slc26a3	A	C	12: 31,514,719 (GRCm39)	Y513S	probably damaging	Het
Slc35b2	T	C	17: 45,877,368 (GRCm39)	V165A	probably benign	Het
Slco3a1	A	G	7: 73,934,361 (GRCm39)	W604R	probably damaging	Het
Tet2	A	G	3: 133,175,238 (GRCm39)	S1370P	possibly damaging	Het
Tmtc4	A	T	14: 123,158,731 (GRCm39)		probably null	Het
Tsga13	A	G	6: 30,889,198 (GRCm39)	V18A	probably benign	Het
Ugt2a3	T	C	5: 87,477,449 (GRCm39)	T317A	probably benign	Het
Zcchc4	A	T	5: 52,941,442 (GRCm39)	D79V	probably damaging	Het

Other mutations in Or4g17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03024:Or4g17	APN	2	111,209,935 (GRCm39)	missense	possibly damaging	0.94
R0526:Or4g17	UTSW	2	111,209,837 (GRCm39)	missense	possibly damaging	0.95
R0731:Or4g17	UTSW	2	111,209,638 (GRCm39)	missense	probably damaging	0.99
R1762:Or4g17	UTSW	2	111,209,918 (GRCm39)	missense	probably damaging	0.99
R1765:Or4g17	UTSW	2	111,209,491 (GRCm39)	missense	probably benign	0.39
R3106:Or4g17	UTSW	2	111,209,840 (GRCm39)	missense	probably benign	0.23
R3803:Or4g17	UTSW	2	111,209,638 (GRCm39)	missense	possibly damaging	0.95
R4005:Or4g17	UTSW	2	111,210,088 (GRCm39)	missense	probably benign	0.05
R4227:Or4g17	UTSW	2	111,209,410 (GRCm39)	missense	probably benign
R4637:Or4g17	UTSW	2	111,209,927 (GRCm39)	missense	probably benign	0.03
R4707:Or4g17	UTSW	2	111,209,990 (GRCm39)	missense	probably damaging	1.00
R4762:Or4g17	UTSW	2	111,210,082 (GRCm39)	missense	probably damaging	1.00
R5150:Or4g17	UTSW	2	111,209,598 (GRCm39)	missense	probably damaging	1.00
R5309:Or4g17	UTSW	2	111,210,179 (GRCm39)	missense	possibly damaging	0.52
R5312:Or4g17	UTSW	2	111,210,179 (GRCm39)	missense	possibly damaging	0.52
R6554:Or4g17	UTSW	2	111,209,504 (GRCm39)	missense	possibly damaging	0.95
R6913:Or4g17	UTSW	2	111,209,347 (GRCm39)	start codon destroyed	probably null	0.03
R6980:Or4g17	UTSW	2	111,209,620 (GRCm39)	missense	possibly damaging	0.77
R6995:Or4g17	UTSW	2	111,209,708 (GRCm39)	missense	probably damaging	1.00
R7168:Or4g17	UTSW	2	111,210,224 (GRCm39)	missense	probably damaging	1.00
R7332:Or4g17	UTSW	2	111,209,738 (GRCm39)	missense	not run
R7464:Or4g17	UTSW	2	111,209,543 (GRCm39)	missense	probably damaging	1.00
R8125:Or4g17	UTSW	2	111,210,086 (GRCm39)	missense	probably damaging	0.99
R8963:Or4g17	UTSW	2	111,209,645 (GRCm39)	missense	probably damaging	1.00
R9660:Or4g17	UTSW	2	111,210,239 (GRCm39)	missense	probably damaging	0.97

Predicted Primers

Posted On

2015-04-17