Incidental Mutation 'R3884:Lyg2'
ID 310571
Institutional Source Beutler Lab
Gene Symbol Lyg2
Ensembl Gene ENSMUSG00000061584
Gene Name lysozyme G-like 2
Synonyms LOC332427
MMRRC Submission 040797-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R3884 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 37945004-37955574 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 37949150 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Proline at position 71 (A71P)
Ref Sequence ENSEMBL: ENSMUSP00000077422 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078307]
AlphaFold Q3V1I0
Predicted Effect probably damaging
Transcript: ENSMUST00000078307
AA Change: A71P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077422
Gene: ENSMUSG00000061584
AA Change: A71P

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
SCOP:d153l__ 39 213 5e-45 SMART
PDB:1LSP|A 40 213 2e-56 PDB
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SLT domain, a protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy6 G A 15: 98,495,055 (GRCm39) S719F probably benign Het
Als2 A G 1: 59,224,727 (GRCm39) V998A probably damaging Het
Ankmy1 T G 1: 92,813,874 (GRCm39) E435A probably damaging Het
Ankrd52 A G 10: 128,224,824 (GRCm39) E820G probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp6v0d2 T A 4: 19,910,677 (GRCm39) D71V probably damaging Het
C3 T C 17: 57,524,173 (GRCm39) probably null Het
Cnot7 A T 8: 40,963,171 (GRCm39) M1K probably null Het
Cntn2 A G 1: 132,456,677 (GRCm39) V123A probably damaging Het
Depdc5 G A 5: 33,101,421 (GRCm39) E904K probably damaging Het
Dip2c G T 13: 9,601,894 (GRCm39) L284F probably damaging Het
Epb41l3 C T 17: 69,581,111 (GRCm39) R552* probably null Het
Gabra4 T C 5: 71,814,600 (GRCm39) D40G probably benign Het
Gm9925 T C 18: 74,198,399 (GRCm39) probably benign Het
Igf2r T A 17: 12,928,355 (GRCm39) Q996L probably benign Het
Klk1b16 T C 7: 43,788,887 (GRCm39) V40A possibly damaging Het
Lin9 G T 1: 180,515,630 (GRCm39) G427* probably null Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Mycbp2 A C 14: 103,532,686 (GRCm39) L390V probably damaging Het
Myl3 A G 9: 110,597,027 (GRCm39) H129R probably damaging Het
Naa16 T C 14: 79,580,702 (GRCm39) K604R probably damaging Het
Nedd4 C T 9: 72,632,359 (GRCm39) P398S probably benign Het
Neurl1a T C 19: 47,241,885 (GRCm39) V309A probably benign Het
Or10a2 A T 7: 106,673,110 (GRCm39) Q25L possibly damaging Het
Or6c210 T C 10: 129,496,407 (GRCm39) V244A probably damaging Het
Pacs1 T C 19: 5,205,787 (GRCm39) Y301C probably damaging Het
Parl A T 16: 20,101,762 (GRCm39) M90K probably damaging Het
Plxnc1 A T 10: 94,746,549 (GRCm39) probably null Het
Prkd2 C A 7: 16,587,180 (GRCm39) S375R probably benign Het
Prss44 T C 9: 110,643,764 (GRCm39) I136T possibly damaging Het
Rock1 G A 18: 10,122,768 (GRCm39) T351I probably damaging Het
Selenon T C 4: 134,267,081 (GRCm39) N507S possibly damaging Het
Slc38a7 C T 8: 96,572,809 (GRCm39) G141R probably damaging Het
Trpm4 C T 7: 44,971,422 (GRCm39) probably null Het
Ttn T A 2: 76,560,705 (GRCm39) N27486I probably damaging Het
Xylb T C 9: 119,209,753 (GRCm39) M346T probably damaging Het
Zbtb17 T C 4: 141,191,886 (GRCm39) F306L probably damaging Het
Other mutations in Lyg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02834:Lyg2 APN 1 37,949,048 (GRCm39) missense probably damaging 1.00
IGL03079:Lyg2 APN 1 37,946,727 (GRCm39) missense possibly damaging 0.90
IGL03123:Lyg2 APN 1 37,954,845 (GRCm39) utr 5 prime probably benign
R0543:Lyg2 UTSW 1 37,950,188 (GRCm39) missense possibly damaging 0.94
R2250:Lyg2 UTSW 1 37,954,816 (GRCm39) missense probably benign 0.25
R2258:Lyg2 UTSW 1 37,948,077 (GRCm39) missense probably benign 0.00
R4807:Lyg2 UTSW 1 37,950,148 (GRCm39) missense possibly damaging 0.54
R5991:Lyg2 UTSW 1 37,954,800 (GRCm39) critical splice donor site probably null
R6328:Lyg2 UTSW 1 37,950,194 (GRCm39) missense probably benign 0.33
R7439:Lyg2 UTSW 1 37,950,218 (GRCm39) missense possibly damaging 0.46
R8172:Lyg2 UTSW 1 37,946,748 (GRCm39) missense probably benign 0.01
R8812:Lyg2 UTSW 1 37,949,054 (GRCm39) missense probably damaging 1.00
Z1176:Lyg2 UTSW 1 37,950,208 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCATCAAGCCAAACCTCTG -3'
(R):5'- TAGCCGTTTGCAAAGCTGG -3'

Sequencing Primer
(F):5'- AGCCAAACCTCTGCCCCTTATG -3'
(R):5'- TCAATGCAGCATCTTGGCAG -3'
Posted On 2015-04-17