Incidental Mutation 'R3956:Ccni'
ID 310690
Institutional Source Beutler Lab
Gene Symbol Ccni
Ensembl Gene ENSMUSG00000063015
Gene Name cyclin I
Synonyms
MMRRC Submission 040833-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3956 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 93329792-93354354 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 93331263 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 236 (L236S)
Ref Sequence ENSEMBL: ENSMUSP00000050189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058550] [ENSMUST00000151568] [ENSMUST00000201823]
AlphaFold Q9Z2V9
Predicted Effect probably damaging
Transcript: ENSMUST00000058550
AA Change: L236S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050189
Gene: ENSMUSG00000063015
AA Change: L236S

DomainStartEndE-ValueType
CYCLIN 50 136 1.18e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123033
Predicted Effect probably benign
Transcript: ENSMUST00000151568
SMART Domains Protein: ENSMUSP00000116224
Gene: ENSMUSG00000063015

DomainStartEndE-ValueType
CYCLIN 50 136 1.18e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201581
Predicted Effect probably benign
Transcript: ENSMUST00000201823
AA Change: L112S

PolyPhen 2 Score 0.178 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000143972
Gene: ENSMUSG00000063015
AA Change: L112S

DomainStartEndE-ValueType
CYCLIN 3 89 7.4e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202150
Meta Mutation Damage Score 0.7680 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.5%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile and do not display any gross physical or behavioral abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,100,805 (GRCm39) K393E possibly damaging Het
Aagab A G 9: 63,526,442 (GRCm39) E155G probably damaging Het
Abca16 A G 7: 120,126,975 (GRCm39) N1221S probably damaging Het
Acad11 A G 9: 103,963,351 (GRCm39) probably benign Het
Acsl1 T A 8: 46,987,495 (GRCm39) L693Q probably damaging Het
Adam2 G A 14: 66,295,059 (GRCm39) S262L probably damaging Het
B3gat1 A G 9: 26,668,324 (GRCm39) T305A possibly damaging Het
BC051076 A G 5: 88,112,110 (GRCm39) noncoding transcript Het
Ccnq C A 11: 78,641,849 (GRCm39) E214* probably null Het
Cdc45 A G 16: 18,624,180 (GRCm39) V119A probably benign Het
Clspn ACGGCGGCGGC A 4: 126,460,230 (GRCm39) probably null Het
Creld1 A G 6: 113,469,190 (GRCm39) D340G possibly damaging Het
Cyrib T C 15: 63,813,823 (GRCm39) Y158C probably damaging Het
Dipk1b C T 2: 26,525,579 (GRCm39) P171L probably benign Het
Dnah2 T A 11: 69,374,847 (GRCm39) I1417L probably benign Het
Efhc1 A C 1: 21,048,890 (GRCm39) K434N probably damaging Het
Evi5l T C 8: 4,241,358 (GRCm39) V297A possibly damaging Het
Fkbp8 T G 8: 70,987,517 (GRCm39) S376A probably damaging Het
Gfod1 A T 13: 43,354,538 (GRCm39) C146S probably damaging Het
Greb1 G T 12: 16,732,300 (GRCm39) P1554T probably damaging Het
Grip1 A T 10: 119,765,931 (GRCm39) I88F probably damaging Het
Hbq1a T C 11: 32,250,214 (GRCm39) probably null Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Kmt2e A G 5: 23,701,023 (GRCm39) T121A probably benign Het
Lmf1 G A 17: 25,873,445 (GRCm39) V317M probably damaging Het
Mfsd2b A T 12: 4,916,848 (GRCm39) F194Y probably damaging Het
Mtmr3 A T 11: 4,441,138 (GRCm39) V504E probably damaging Het
Neb C T 2: 52,091,975 (GRCm39) V5030M possibly damaging Het
Nup210l A T 3: 90,100,361 (GRCm39) R1462S possibly damaging Het
Or5ac17 G A 16: 59,036,428 (GRCm39) Q183* probably null Het
Or5al1 A G 2: 85,990,282 (GRCm39) V144A probably benign Het
Or5al5 C T 2: 85,961,363 (GRCm39) V215I probably benign Het
Pmfbp1 A G 8: 110,256,801 (GRCm39) S502G probably benign Het
Prb1c G T 6: 132,338,814 (GRCm39) Q135K unknown Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
Qng1 A G 13: 58,532,203 (GRCm39) S118P probably damaging Het
Ralgapa2 C T 2: 146,277,884 (GRCm39) V426I probably damaging Het
Rasgrf2 A G 13: 92,130,974 (GRCm39) S696P probably damaging Het
Riok3 T A 18: 12,276,031 (GRCm39) Y242* probably null Het
Robo2 T G 16: 73,758,755 (GRCm39) Y672S probably damaging Het
Rsbn1 A G 3: 103,835,991 (GRCm39) H343R probably damaging Het
Sar1a A T 10: 61,522,172 (GRCm39) N88I possibly damaging Het
Sgcz A G 8: 37,993,346 (GRCm39) probably benign Het
Spmip9 A G 6: 70,890,469 (GRCm39) Y108H possibly damaging Het
Tbc1d9 C T 8: 83,960,161 (GRCm39) T138I probably damaging Het
Tlcd5 C A 9: 43,022,808 (GRCm39) C182F probably damaging Het
Tmem131l C A 3: 83,817,726 (GRCm39) C1257F probably damaging Het
Top6bl T A 19: 4,742,525 (GRCm39) T214S probably benign Het
Ttn A G 2: 76,799,593 (GRCm39) V429A possibly damaging Het
Umodl1 A G 17: 31,221,837 (GRCm39) T1280A probably benign Het
Xpnpep3 A G 15: 81,335,230 (GRCm39) probably benign Het
Other mutations in Ccni
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02301:Ccni APN 5 93,336,034 (GRCm39) missense possibly damaging 0.77
IGL02545:Ccni APN 5 93,335,636 (GRCm39) missense probably benign 0.01
IGL02865:Ccni APN 5 93,331,195 (GRCm39) missense probably benign 0.04
R0234:Ccni UTSW 5 93,350,186 (GRCm39) missense probably benign 0.02
R0234:Ccni UTSW 5 93,350,186 (GRCm39) missense probably benign 0.02
R0541:Ccni UTSW 5 93,335,563 (GRCm39) missense probably benign 0.00
R0718:Ccni UTSW 5 93,350,175 (GRCm39) missense probably benign 0.00
R0760:Ccni UTSW 5 93,331,188 (GRCm39) missense possibly damaging 0.89
R1656:Ccni UTSW 5 93,335,933 (GRCm39) splice site probably null
R1752:Ccni UTSW 5 93,350,315 (GRCm39) start gained probably benign
R1817:Ccni UTSW 5 93,335,967 (GRCm39) missense possibly damaging 0.89
R3551:Ccni UTSW 5 93,335,620 (GRCm39) missense probably benign 0.05
R3552:Ccni UTSW 5 93,335,620 (GRCm39) missense probably benign 0.05
R4809:Ccni UTSW 5 93,335,429 (GRCm39) intron probably benign
R4901:Ccni UTSW 5 93,331,003 (GRCm39) missense probably damaging 1.00
R4937:Ccni UTSW 5 93,336,113 (GRCm39) splice site probably null
R4975:Ccni UTSW 5 93,335,553 (GRCm39) missense possibly damaging 0.83
R7120:Ccni UTSW 5 93,331,190 (GRCm39) nonsense probably null
R8923:Ccni UTSW 5 93,335,943 (GRCm39) missense probably damaging 1.00
R9697:Ccni UTSW 5 93,350,201 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTTGGAGAAATCTGGGCC -3'
(R):5'- TCTGCCTTCATGTGAGTGC -3'

Sequencing Primer
(F):5'- CTTGGAGAAATCTGGGCCTGAGAC -3'
(R):5'- GCAAGCATGTGCACGTATTTCAG -3'
Posted On 2015-04-29