Incidental Mutation 'R3977:Tas2r103'
ID 311071
Institutional Source Beutler Lab
Gene Symbol Tas2r103
Ensembl Gene ENSMUSG00000030196
Gene Name taste receptor, type 2, member 103
Synonyms TRB2, T2R3, mGR03, mt2r63, Tas2r10, Tas2r3, EG667992
MMRRC Submission 040940-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R3977 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 133013126-133014064 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 133013280 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 262 (L262P)
Ref Sequence ENSEMBL: ENSMUSP00000032317 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032317]
AlphaFold Q9JKA3
Predicted Effect probably benign
Transcript: ENSMUST00000032317
AA Change: L262P

PolyPhen 2 Score 0.161 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000032317
Gene: ENSMUSG00000030196
AA Change: L262P

DomainStartEndE-ValueType
Pfam:TAS2R 5 301 1.5e-79 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace C T 11: 105,872,664 (GRCm39) P942L possibly damaging Het
Adam28 A G 14: 68,848,443 (GRCm39) V671A probably benign Het
Arfgef1 A G 1: 10,279,859 (GRCm39) V236A probably benign Het
B020004C17Rik G T 14: 57,254,645 (GRCm39) M156I possibly damaging Het
Bicral T A 17: 47,141,917 (GRCm39) M1L unknown Het
Brpf3 A G 17: 29,026,016 (GRCm39) E363G possibly damaging Het
Ccdc96 T C 5: 36,642,510 (GRCm39) L172P possibly damaging Het
Cln3 G A 7: 126,179,308 (GRCm39) probably benign Het
Dnah7c T C 1: 46,668,071 (GRCm39) I1526T possibly damaging Het
Entr1 T A 2: 26,274,805 (GRCm39) N364I probably damaging Het
Fmo3 T G 1: 162,786,147 (GRCm39) E281A probably damaging Het
Frem2 A G 3: 53,559,491 (GRCm39) I1672T probably benign Het
Gbp2b A G 3: 142,309,470 (GRCm39) I194V probably benign Het
Gprc6a C A 10: 51,497,197 (GRCm39) V449L probably benign Het
Hk1 A G 10: 62,126,098 (GRCm39) V396A probably benign Het
Hoxc13 T C 15: 102,829,675 (GRCm39) V18A possibly damaging Het
Hr A G 14: 70,801,024 (GRCm39) T699A probably benign Het
Il19 A T 1: 130,863,770 (GRCm39) C74S probably damaging Het
Krt1c T C 15: 101,719,562 (GRCm39) T703A unknown Het
Lrig2 A T 3: 104,365,160 (GRCm39) V664E probably damaging Het
Lrrc37a T C 11: 103,348,430 (GRCm39) K2755R unknown Het
Man1c1 G C 4: 134,430,749 (GRCm39) P11R probably damaging Het
Mbtd1 A G 11: 93,796,001 (GRCm39) N13D probably benign Het
Mfsd4b5 T C 10: 39,850,704 (GRCm39) probably benign Het
Nras A G 3: 102,967,541 (GRCm39) I46V probably benign Het
Oasl1 C T 5: 115,070,957 (GRCm39) T274I probably damaging Het
Ogfod2 C A 5: 124,251,272 (GRCm39) probably null Het
Or10q3 C A 19: 11,847,869 (GRCm39) R237L possibly damaging Het
Or10v1 T A 19: 11,873,880 (GRCm39) F165Y probably damaging Het
Or11a4 T C 17: 37,536,049 (GRCm39) V11A probably benign Het
Or2w1b T A 13: 21,300,031 (GRCm39) H56Q probably benign Het
Or4c3 C A 2: 89,852,089 (GRCm39) G107V probably damaging Het
Or6c5 C T 10: 129,074,377 (GRCm39) R120C probably damaging Het
Pkmyt1 A G 17: 23,954,305 (GRCm39) M362V probably benign Het
Ppfia2 A G 10: 106,666,490 (GRCm39) T399A possibly damaging Het
Ppp1r12b A G 1: 134,693,713 (GRCm39) S983P probably benign Het
Ptpn22 A G 3: 103,780,957 (GRCm39) probably benign Het
Raph1 A T 1: 60,537,682 (GRCm39) D491E probably benign Het
Rc3h1 A G 1: 160,786,969 (GRCm39) probably null Het
Rtn4 T C 11: 29,643,819 (GRCm39) L5P probably benign Het
Slc23a4 C T 6: 34,930,723 (GRCm39) V400I probably benign Het
Slco1a5 A G 6: 142,204,698 (GRCm39) probably benign Het
Smpd1 T C 7: 105,205,108 (GRCm39) F329S probably benign Het
Sycp2l A G 13: 41,295,440 (GRCm39) I334M probably damaging Het
Ten1 G A 11: 116,107,771 (GRCm39) probably null Het
Tfap2d C G 1: 19,174,718 (GRCm39) S57C possibly damaging Het
Tnr A G 1: 159,719,593 (GRCm39) M957V probably benign Het
Trbv13-3 A G 6: 41,107,079 (GRCm39) probably benign Het
Trp53rkb C T 2: 166,637,446 (GRCm39) A134V possibly damaging Het
Trp63 A G 16: 25,639,490 (GRCm39) probably benign Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Vmn2r74 T C 7: 85,607,345 (GRCm39) Y126C probably benign Het
Vmn2r96 T A 17: 18,817,941 (GRCm39) I698N probably damaging Het
Other mutations in Tas2r103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02230:Tas2r103 APN 6 133,014,019 (GRCm39) missense possibly damaging 0.86
IGL02332:Tas2r103 APN 6 133,013,475 (GRCm39) missense probably benign 0.21
IGL03122:Tas2r103 APN 6 133,013,872 (GRCm39) missense probably damaging 1.00
IGL03167:Tas2r103 APN 6 133,013,623 (GRCm39) missense probably damaging 0.98
R0380:Tas2r103 UTSW 6 133,013,166 (GRCm39) missense probably damaging 1.00
R0671:Tas2r103 UTSW 6 133,013,313 (GRCm39) missense probably benign 0.01
R1700:Tas2r103 UTSW 6 133,013,774 (GRCm39) missense probably damaging 1.00
R2098:Tas2r103 UTSW 6 133,013,560 (GRCm39) missense probably benign
R3979:Tas2r103 UTSW 6 133,013,280 (GRCm39) missense probably benign 0.16
R3980:Tas2r103 UTSW 6 133,013,280 (GRCm39) missense probably benign 0.16
R4924:Tas2r103 UTSW 6 133,013,161 (GRCm39) missense probably benign 0.02
R5779:Tas2r103 UTSW 6 133,013,908 (GRCm39) missense probably benign 0.02
R5839:Tas2r103 UTSW 6 133,013,779 (GRCm39) missense probably benign 0.06
R6265:Tas2r103 UTSW 6 133,013,494 (GRCm39) missense probably damaging 1.00
R7768:Tas2r103 UTSW 6 133,013,812 (GRCm39) missense probably benign 0.06
R8851:Tas2r103 UTSW 6 133,013,896 (GRCm39) missense
R9435:Tas2r103 UTSW 6 133,013,686 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATCCCTGATATGATTTAGGGGC -3'
(R):5'- AGCACTGGGTTTACACTCACC -3'

Sequencing Primer
(F):5'- ATGATTTAGGGGCCCCAATTC -3'
(R):5'- CATTCGCTGTGTCTTTGACAATG -3'
Posted On 2015-04-29