Incidental Mutation 'R3977:Or11a4'
ID 311097
Institutional Source Beutler Lab
Gene Symbol Or11a4
Ensembl Gene ENSMUSG00000064121
Gene Name olfactory receptor family 11 subfamily A member 4
Synonyms MOR121-1, Olfr96, GA_x6K02T2PSCP-1665046-1665987
MMRRC Submission 040940-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R3977 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 37535982-37537032 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37536049 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 11 (V11A)
Ref Sequence ENSEMBL: ENSMUSP00000151151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078209] [ENSMUST00000213475] [ENSMUST00000214482]
AlphaFold Q8VFE3
Predicted Effect probably benign
Transcript: ENSMUST00000078209
AA Change: V11A

PolyPhen 2 Score 0.240 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000077338
Gene: ENSMUSG00000064121
AA Change: V11A

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.6e-53 PFAM
Pfam:7tm_1 43 291 6.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213475
AA Change: V11A

PolyPhen 2 Score 0.240 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000214482
AA Change: V11A

PolyPhen 2 Score 0.240 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 96% (50/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace C T 11: 105,872,664 (GRCm39) P942L possibly damaging Het
Adam28 A G 14: 68,848,443 (GRCm39) V671A probably benign Het
Arfgef1 A G 1: 10,279,859 (GRCm39) V236A probably benign Het
B020004C17Rik G T 14: 57,254,645 (GRCm39) M156I possibly damaging Het
Bicral T A 17: 47,141,917 (GRCm39) M1L unknown Het
Brpf3 A G 17: 29,026,016 (GRCm39) E363G possibly damaging Het
Ccdc96 T C 5: 36,642,510 (GRCm39) L172P possibly damaging Het
Cln3 G A 7: 126,179,308 (GRCm39) probably benign Het
Dnah7c T C 1: 46,668,071 (GRCm39) I1526T possibly damaging Het
Entr1 T A 2: 26,274,805 (GRCm39) N364I probably damaging Het
Fmo3 T G 1: 162,786,147 (GRCm39) E281A probably damaging Het
Frem2 A G 3: 53,559,491 (GRCm39) I1672T probably benign Het
Gbp2b A G 3: 142,309,470 (GRCm39) I194V probably benign Het
Gprc6a C A 10: 51,497,197 (GRCm39) V449L probably benign Het
Hk1 A G 10: 62,126,098 (GRCm39) V396A probably benign Het
Hoxc13 T C 15: 102,829,675 (GRCm39) V18A possibly damaging Het
Hr A G 14: 70,801,024 (GRCm39) T699A probably benign Het
Il19 A T 1: 130,863,770 (GRCm39) C74S probably damaging Het
Krt1c T C 15: 101,719,562 (GRCm39) T703A unknown Het
Lrig2 A T 3: 104,365,160 (GRCm39) V664E probably damaging Het
Lrrc37a T C 11: 103,348,430 (GRCm39) K2755R unknown Het
Man1c1 G C 4: 134,430,749 (GRCm39) P11R probably damaging Het
Mbtd1 A G 11: 93,796,001 (GRCm39) N13D probably benign Het
Mfsd4b5 T C 10: 39,850,704 (GRCm39) probably benign Het
Nras A G 3: 102,967,541 (GRCm39) I46V probably benign Het
Oasl1 C T 5: 115,070,957 (GRCm39) T274I probably damaging Het
Ogfod2 C A 5: 124,251,272 (GRCm39) probably null Het
Or10q3 C A 19: 11,847,869 (GRCm39) R237L possibly damaging Het
Or10v1 T A 19: 11,873,880 (GRCm39) F165Y probably damaging Het
Or2w1b T A 13: 21,300,031 (GRCm39) H56Q probably benign Het
Or4c3 C A 2: 89,852,089 (GRCm39) G107V probably damaging Het
Or6c5 C T 10: 129,074,377 (GRCm39) R120C probably damaging Het
Pkmyt1 A G 17: 23,954,305 (GRCm39) M362V probably benign Het
Ppfia2 A G 10: 106,666,490 (GRCm39) T399A possibly damaging Het
Ppp1r12b A G 1: 134,693,713 (GRCm39) S983P probably benign Het
Ptpn22 A G 3: 103,780,957 (GRCm39) probably benign Het
Raph1 A T 1: 60,537,682 (GRCm39) D491E probably benign Het
Rc3h1 A G 1: 160,786,969 (GRCm39) probably null Het
Rtn4 T C 11: 29,643,819 (GRCm39) L5P probably benign Het
Slc23a4 C T 6: 34,930,723 (GRCm39) V400I probably benign Het
Slco1a5 A G 6: 142,204,698 (GRCm39) probably benign Het
Smpd1 T C 7: 105,205,108 (GRCm39) F329S probably benign Het
Sycp2l A G 13: 41,295,440 (GRCm39) I334M probably damaging Het
Tas2r103 A G 6: 133,013,280 (GRCm39) L262P probably benign Het
Ten1 G A 11: 116,107,771 (GRCm39) probably null Het
Tfap2d C G 1: 19,174,718 (GRCm39) S57C possibly damaging Het
Tnr A G 1: 159,719,593 (GRCm39) M957V probably benign Het
Trbv13-3 A G 6: 41,107,079 (GRCm39) probably benign Het
Trp53rkb C T 2: 166,637,446 (GRCm39) A134V possibly damaging Het
Trp63 A G 16: 25,639,490 (GRCm39) probably benign Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Vmn2r74 T C 7: 85,607,345 (GRCm39) Y126C probably benign Het
Vmn2r96 T A 17: 18,817,941 (GRCm39) I698N probably damaging Het
Other mutations in Or11a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01868:Or11a4 APN 17 37,536,043 (GRCm39) missense probably benign 0.05
IGL02151:Or11a4 APN 17 37,536,057 (GRCm39) missense probably damaging 1.00
IGL02335:Or11a4 APN 17 37,536,217 (GRCm39) missense probably damaging 0.97
R0360:Or11a4 UTSW 17 37,536,934 (GRCm39) missense possibly damaging 0.49
R0364:Or11a4 UTSW 17 37,536,934 (GRCm39) missense possibly damaging 0.49
R1763:Or11a4 UTSW 17 37,536,321 (GRCm39) missense probably benign 0.02
R6116:Or11a4 UTSW 17 37,536,459 (GRCm39) missense probably benign 0.00
R6248:Or11a4 UTSW 17 37,536,451 (GRCm39) nonsense probably null
R6378:Or11a4 UTSW 17 37,536,688 (GRCm39) missense probably benign 0.21
R6518:Or11a4 UTSW 17 37,536,159 (GRCm39) missense probably benign 0.05
R6614:Or11a4 UTSW 17 37,536,790 (GRCm39) missense probably benign 0.01
R6798:Or11a4 UTSW 17 37,536,697 (GRCm39) missense probably damaging 1.00
R6874:Or11a4 UTSW 17 37,536,238 (GRCm39) missense probably benign 0.00
R7468:Or11a4 UTSW 17 37,536,276 (GRCm39) missense probably benign 0.01
R7820:Or11a4 UTSW 17 37,536,786 (GRCm39) missense probably benign 0.00
R7852:Or11a4 UTSW 17 37,536,163 (GRCm39) missense probably benign 0.01
R8322:Or11a4 UTSW 17 37,536,241 (GRCm39) missense probably damaging 0.99
R8481:Or11a4 UTSW 17 37,536,295 (GRCm39) missense probably damaging 1.00
R8933:Or11a4 UTSW 17 37,536,346 (GRCm39) missense possibly damaging 0.96
X0027:Or11a4 UTSW 17 37,536,634 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- CCCTAGGCCATTAGGAGTATGC -3'
(R):5'- TCTCTATGAAGGACAGATTCACCAG -3'

Sequencing Primer
(F):5'- GCCATTAGGAGTATGCTACCTTAAAG -3'
(R):5'- TTCACCAGAAAGAAATACATGGGTG -3'
Posted On 2015-04-29