Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00488:Tasl'

3113

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tasl

Ensembl Gene

Gene Name

TLR adaptor interacting with endolysosomal SLC15A4

Synonyms

5430427O19Rik

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL00488

Quality Score

Status

Chromosome

Chromosomal Location

84913960-84935105 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 84931985 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 184 (Y184N)

Ref Sequence

ENSEMBL: ENSMUSP00000109609 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000113976]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000113976
AA Change: Y184N

PolyPhen 2 Score 0.561 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000109609
Gene: ENSMUSG00000025058
AA Change: Y184N

Domain	Start	End	E-Value	Type
Pfam:DUF4569	1	293	7.6e-108	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl4	T	A	3: 151,248,478 (GRCm39)	S717T	probably damaging	Het
Bcorl1	T	G	X: 47,494,919 (GRCm39)	V1730G	probably damaging	Het
Cchcr1	A	G	17: 35,839,469 (GRCm39)	D585G	possibly damaging	Het
Dnah6	A	T	6: 73,063,190 (GRCm39)	N2637K	possibly damaging	Het
Erg	C	A	16: 95,170,848 (GRCm39)		probably benign	Het
Mak	C	T	13: 41,209,165 (GRCm39)		probably benign	Het
Max	T	C	12: 76,985,404 (GRCm39)	S132G	probably damaging	Het
Nfam1	T	C	15: 82,907,185 (GRCm39)	Y4C	probably benign	Het
Orc5	G	T	5: 22,721,771 (GRCm39)	D360E	probably damaging	Het
Prkdc	T	A	16: 15,593,711 (GRCm39)		probably null	Het
Ptpn18	G	A	1: 34,502,200 (GRCm39)	R72K	probably damaging	Het
R3hcc1l	A	G	19: 42,552,391 (GRCm39)	I463V	probably benign	Het
Rapgef2	T	C	3: 78,999,332 (GRCm39)	E480G	possibly damaging	Het
Rictor	T	A	15: 6,816,071 (GRCm39)	D1114E	probably damaging	Het
Sestd1	A	G	2: 77,042,796 (GRCm39)	S253P	possibly damaging	Het
Slk	C	T	19: 47,608,148 (GRCm39)	T367I	probably benign	Het
Tcirg1	T	G	19: 3,949,108 (GRCm39)	I394L	possibly damaging	Het
Ubn1	T	C	16: 4,899,778 (GRCm39)	S1097P	probably benign	Het
Ugt2b34	T	A	5: 87,040,818 (GRCm39)	H368L	probably damaging	Het
Wdr20rt	T	C	12: 65,272,744 (GRCm39)	V69A	possibly damaging	Het
Wnt16	T	C	6: 22,291,012 (GRCm39)	S147P	probably damaging	Het

Posted On

2012-04-20