Incidental Mutation 'R4006:Zfp974'
ID 311472
Institutional Source Beutler Lab
Gene Symbol Zfp974
Ensembl Gene ENSMUSG00000070709
Gene Name zinc finger protein 974
Synonyms 1700049G17Rik
MMRRC Submission 040845-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R4006 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 27606817-27628885 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27611677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 16 (T16I)
Ref Sequence ENSEMBL: ENSMUSP00000096238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]
AlphaFold Q3UVF6
Predicted Effect possibly damaging
Transcript: ENSMUST00000098639
AA Change: T16I

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709
AA Change: T16I

DomainStartEndE-ValueType
ZnF_C2H2 99 121 8.81e-2 SMART
ZnF_C2H2 127 149 1.82e-3 SMART
ZnF_C2H2 155 177 3.11e-2 SMART
ZnF_C2H2 201 223 2.15e-5 SMART
ZnF_C2H2 229 251 1.18e-2 SMART
ZnF_C2H2 257 279 1.47e-3 SMART
ZnF_C2H2 285 307 1.79e-2 SMART
ZnF_C2H2 313 335 2.24e-3 SMART
ZnF_C2H2 341 363 9.73e-4 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
ZnF_C2H2 397 419 6.42e-4 SMART
ZnF_C2H2 425 447 3.63e-3 SMART
ZnF_C2H2 453 475 1.28e-3 SMART
ZnF_C2H2 481 503 1.26e-2 SMART
ZnF_C2H2 509 531 1.38e-3 SMART
ZnF_C2H2 537 559 3.83e-2 SMART
ZnF_C2H2 565 587 1.95e-3 SMART
ZnF_C2H2 593 615 4.61e-5 SMART
ZnF_C2H2 621 643 1.95e-3 SMART
ZnF_C2H2 649 671 1.03e-2 SMART
ZnF_C2H2 677 699 5.5e-3 SMART
ZnF_C2H2 705 727 2.37e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129341
AA Change: T90I

PolyPhen 2 Score 0.355 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709
AA Change: T90I

DomainStartEndE-ValueType
KRAB 14 75 7.5e-37 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 A G 10: 61,038,600 (GRCm39) probably null Het
Ano4 C A 10: 88,924,125 (GRCm39) V329L probably benign Het
Camkv C T 9: 107,823,840 (GRCm39) R196W probably damaging Het
Chd9 T C 8: 91,660,188 (GRCm39) S383P probably benign Het
Cimip1 T C 2: 173,367,880 (GRCm39) probably null Het
Cul4a A G 8: 13,172,859 (GRCm39) N164S probably benign Het
Dsg4 G A 18: 20,604,022 (GRCm39) E830K probably damaging Het
Fbln2 C A 6: 91,246,943 (GRCm39) probably null Het
Grm8 T C 6: 27,981,229 (GRCm39) Y227C probably damaging Het
Gsn G A 2: 35,197,633 (GRCm39) W717* probably null Het
Htr2a A T 14: 74,879,581 (GRCm39) H70L probably benign Het
Igfn1 C T 1: 135,910,100 (GRCm39) probably null Het
Iqsec3 A G 6: 121,353,187 (GRCm39) S1144P probably damaging Het
Lpin2 C T 17: 71,553,496 (GRCm39) T878I probably damaging Het
Lrrn2 A T 1: 132,865,478 (GRCm39) D181V probably damaging Het
Mc1r T C 8: 124,134,376 (GRCm39) F43S probably damaging Het
Mst1 A G 9: 107,960,147 (GRCm39) E377G possibly damaging Het
Nfatc3 T A 8: 106,835,471 (GRCm39) I931N probably benign Het
Nup188 G A 2: 30,199,890 (GRCm39) D305N probably damaging Het
Or5e1 C T 7: 108,354,468 (GRCm39) T135I probably damaging Het
Or8k35 T C 2: 86,424,908 (GRCm39) D88G probably benign Het
Pate3 T A 9: 35,557,398 (GRCm39) H86L probably damaging Het
Pla2r1 A T 2: 60,353,217 (GRCm39) F248Y probably damaging Het
Ppp1r37 A G 7: 19,268,994 (GRCm39) S169P probably damaging Het
Pramex1 A T X: 134,514,374 (GRCm39) L305Q probably damaging Het
Prkcg G A 7: 3,375,983 (GRCm39) V492I probably damaging Het
Psmb11 T A 14: 54,863,103 (GRCm39) V107E probably damaging Het
Reg1 A G 6: 78,404,013 (GRCm39) D60G probably null Het
Shoc1 A T 4: 59,076,500 (GRCm39) V481D possibly damaging Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Trim23 A G 13: 104,324,131 (GRCm39) T177A probably benign Het
Xkr4 A T 1: 3,491,998 (GRCm39) F308L probably benign Het
Xylt1 A G 7: 117,074,748 (GRCm39) I122V probably benign Het
Zan T C 5: 137,462,201 (GRCm39) T993A unknown Het
Zbtb20 T C 16: 43,429,762 (GRCm39) L18P probably damaging Het
Zfp292 T C 4: 34,807,744 (GRCm39) I1767V probably benign Het
Zfp292 G T 4: 34,809,611 (GRCm39) S1144R possibly damaging Het
Zfp317 T G 9: 19,559,333 (GRCm39) W516G possibly damaging Het
Other mutations in Zfp974
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00836:Zfp974 APN 7 27,610,315 (GRCm39) missense possibly damaging 0.83
IGL01805:Zfp974 APN 7 27,611,689 (GRCm39) splice site probably benign
IGL02313:Zfp974 APN 7 27,611,678 (GRCm39) missense possibly damaging 0.53
IGL02449:Zfp974 APN 7 27,611,152 (GRCm39) missense probably benign
R0362:Zfp974 UTSW 7 27,626,819 (GRCm39) splice site probably benign
R0372:Zfp974 UTSW 7 27,620,120 (GRCm39) critical splice donor site probably null
R0379:Zfp974 UTSW 7 27,610,357 (GRCm39) missense probably damaging 0.98
R0699:Zfp974 UTSW 7 27,611,416 (GRCm39) missense possibly damaging 0.56
R0791:Zfp974 UTSW 7 27,609,510 (GRCm39) nonsense probably null
R1411:Zfp974 UTSW 7 27,610,634 (GRCm39) missense probably benign 0.00
R1567:Zfp974 UTSW 7 27,610,148 (GRCm39) missense probably damaging 0.99
R1747:Zfp974 UTSW 7 27,610,506 (GRCm39) missense possibly damaging 0.61
R1837:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1838:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1839:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R2311:Zfp974 UTSW 7 27,609,866 (GRCm39) missense possibly damaging 0.73
R4303:Zfp974 UTSW 7 27,609,657 (GRCm39) missense possibly damaging 0.85
R4541:Zfp974 UTSW 7 27,625,829 (GRCm39) missense probably damaging 0.99
R4771:Zfp974 UTSW 7 27,625,733 (GRCm39) missense probably damaging 0.96
R4889:Zfp974 UTSW 7 27,610,244 (GRCm39) missense possibly damaging 0.86
R5332:Zfp974 UTSW 7 27,625,715 (GRCm39) missense probably benign 0.01
R5537:Zfp974 UTSW 7 27,611,671 (GRCm39) critical splice acceptor site probably benign
R5906:Zfp974 UTSW 7 27,610,230 (GRCm39) missense possibly damaging 0.72
R5908:Zfp974 UTSW 7 27,610,382 (GRCm39) missense probably benign 0.01
R6419:Zfp974 UTSW 7 27,610,940 (GRCm39) missense possibly damaging 0.72
R6654:Zfp974 UTSW 7 27,625,828 (GRCm39) missense probably damaging 1.00
R6731:Zfp974 UTSW 7 27,611,074 (GRCm39) missense possibly damaging 0.93
R7162:Zfp974 UTSW 7 27,610,944 (GRCm39) missense possibly damaging 0.71
R7316:Zfp974 UTSW 7 27,609,863 (GRCm39) missense possibly damaging 0.93
R7484:Zfp974 UTSW 7 27,611,559 (GRCm39) missense possibly damaging 0.72
R7663:Zfp974 UTSW 7 27,611,110 (GRCm39) missense possibly damaging 0.74
R7664:Zfp974 UTSW 7 27,610,137 (GRCm39) missense possibly damaging 0.86
R8052:Zfp974 UTSW 7 27,610,697 (GRCm39) missense probably damaging 1.00
R8698:Zfp974 UTSW 7 27,610,361 (GRCm39) missense possibly damaging 0.90
R8700:Zfp974 UTSW 7 27,609,472 (GRCm39) missense possibly damaging 0.86
R8938:Zfp974 UTSW 7 27,610,311 (GRCm39) missense possibly damaging 0.74
R8972:Zfp974 UTSW 7 27,610,589 (GRCm39) missense probably benign 0.06
R9212:Zfp974 UTSW 7 27,610,052 (GRCm39) missense possibly damaging 0.86
R9236:Zfp974 UTSW 7 27,610,342 (GRCm39) missense possibly damaging 0.51
R9335:Zfp974 UTSW 7 27,611,476 (GRCm39) missense probably benign 0.02
R9436:Zfp974 UTSW 7 27,611,094 (GRCm39) missense probably benign 0.24
R9740:Zfp974 UTSW 7 27,610,025 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGTAACCTTTTGACCAGCATCTC -3'
(R):5'- GGATTGGACATGTCTTCCCATTTC -3'

Sequencing Primer
(F):5'- GACCAGCATCTCCTCCTTTATAAC -3'
(R):5'- CCAACCTGCTCTACTGTAAAGTG -3'
Posted On 2015-04-29