Incidental Mutation 'R0384:Cyp2j9'
ID 31153
Institutional Source Beutler Lab
Gene Symbol Cyp2j9
Ensembl Gene ENSMUSG00000015224
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 9
Synonyms 8430417E17Rik
MMRRC Submission 038590-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0384 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 96456666-96479815 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 96474122 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 106 (H106R)
Ref Sequence ENSEMBL: ENSMUSP00000050464 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055693]
AlphaFold Q924D1
Predicted Effect probably benign
Transcript: ENSMUST00000055693
AA Change: H106R

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000050464
Gene: ENSMUSG00000015224
AA Change: H106R

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Pfam:p450 44 498 8.7e-137 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126509
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.8%
  • 20x: 91.7%
Validation Efficiency 100% (72/72)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam8 T A 7: 139,566,725 (GRCm39) probably benign Het
Akr1b8 T C 6: 34,341,265 (GRCm39) probably benign Het
Arhgef39 A G 4: 43,498,613 (GRCm39) L117P probably damaging Het
Atp13a1 A T 8: 70,249,974 (GRCm39) Q356L possibly damaging Het
Bmp2k T A 5: 97,178,984 (GRCm39) probably benign Het
Ccdc141 A G 2: 76,857,992 (GRCm39) V1063A probably damaging Het
Col20a1 T C 2: 180,640,955 (GRCm39) Y568H probably benign Het
Crabp2 T C 3: 87,860,328 (GRCm39) V134A possibly damaging Het
Cyp19a1 T C 9: 54,080,025 (GRCm39) K265E probably benign Het
Dcps T C 9: 35,087,239 (GRCm39) K9R probably damaging Het
Dnajc6 C T 4: 101,456,153 (GRCm39) T47I probably damaging Het
Dnhd1 T G 7: 105,369,321 (GRCm39) S4315A possibly damaging Het
Dnmt3l A T 10: 77,888,571 (GRCm39) I158F possibly damaging Het
Dock3 A G 9: 106,779,094 (GRCm39) probably benign Het
Eefsec A G 6: 88,258,632 (GRCm39) probably null Het
Fam204a T C 19: 60,209,728 (GRCm39) M1V probably null Het
Fam98b T C 2: 117,098,328 (GRCm39) V266A possibly damaging Het
Fat2 A T 11: 55,160,291 (GRCm39) I3274N possibly damaging Het
Fbh1 A G 2: 11,754,389 (GRCm39) I198T probably damaging Het
Fer T C 17: 64,231,179 (GRCm39) probably benign Het
Fhad1 T A 4: 141,729,737 (GRCm39) M89L probably benign Het
Fjx1 C A 2: 102,281,452 (GRCm39) C161F probably damaging Het
Fkbp7 T A 2: 76,496,168 (GRCm39) probably benign Het
Gm42669 T A 5: 107,656,664 (GRCm39) C976S probably benign Het
Gm4845 T C 1: 141,184,823 (GRCm39) noncoding transcript Het
Herc1 T A 9: 66,388,332 (GRCm39) probably benign Het
Hook3 C T 8: 26,534,263 (GRCm39) probably null Het
Idh2 C T 7: 79,748,005 (GRCm39) A232T probably damaging Het
Itga2b A T 11: 102,356,188 (GRCm39) probably null Het
Klk1b21 T C 7: 43,754,917 (GRCm39) Y71H probably benign Het
Kndc1 A T 7: 139,490,515 (GRCm39) N339I possibly damaging Het
Ky C T 9: 102,419,289 (GRCm39) T432I probably benign Het
Map4 C T 9: 109,863,696 (GRCm39) T307I probably damaging Het
Matn1 T C 4: 130,671,787 (GRCm39) L18P probably benign Het
Mindy4 G A 6: 55,193,669 (GRCm39) D121N probably damaging Het
Mpv17l A T 16: 13,758,863 (GRCm39) I96L probably benign Het
Msto1 G A 3: 88,817,646 (GRCm39) Q441* probably null Het
Muc5ac A G 7: 141,365,988 (GRCm39) H2048R possibly damaging Het
Musk T C 4: 58,373,711 (GRCm39) *879Q probably null Het
Nat8f2 T C 6: 85,845,350 (GRCm39) Y4C possibly damaging Het
Ncaph2 T A 15: 89,253,594 (GRCm39) I282N probably benign Het
Nid1 A G 13: 13,638,421 (GRCm39) T114A probably benign Het
Npr1 C A 3: 90,372,474 (GRCm39) G113C probably damaging Het
Nrxn1 G A 17: 90,515,775 (GRCm39) P193S probably damaging Het
Nwd2 T C 5: 63,963,025 (GRCm39) F870L probably benign Het
Or10h1b A G 17: 33,395,522 (GRCm39) I45V probably damaging Het
Or4c122 A G 2: 89,079,414 (GRCm39) I208T possibly damaging Het
Or6c5c T A 10: 129,298,909 (GRCm39) Y121* probably null Het
Or8k30 T A 2: 86,339,727 (GRCm39) I308K possibly damaging Het
Phf14 A G 6: 11,997,019 (GRCm39) probably benign Het
Pnpla5 G T 15: 84,004,920 (GRCm39) L144M probably damaging Het
Prdm2 T C 4: 142,862,258 (GRCm39) E344G probably benign Het
Psmd12 T C 11: 107,376,547 (GRCm39) V61A probably benign Het
Relt T C 7: 100,496,712 (GRCm39) D385G probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Scg2 T A 1: 79,413,266 (GRCm39) I446F probably benign Het
Sema3b G A 9: 107,478,165 (GRCm39) L407F probably damaging Het
Slc25a13 A T 6: 6,042,600 (GRCm39) Y601* probably null Het
Sun5 C T 2: 153,700,885 (GRCm39) V270I probably benign Het
Tex52 A G 6: 128,356,496 (GRCm39) Y63C probably damaging Het
Tmem138 A G 19: 10,552,186 (GRCm39) probably benign Het
Tnpo3 A G 6: 29,582,163 (GRCm39) probably null Het
Tspoap1 A T 11: 87,657,280 (GRCm39) Q364L probably damaging Het
Ttc41 T C 10: 86,599,811 (GRCm39) L1037P probably damaging Het
Ugcg T A 4: 59,220,387 (GRCm39) D393E possibly damaging Het
Vmn1r184 T C 7: 25,967,076 (GRCm39) I274T probably benign Het
Vmn2r27 A G 6: 124,200,871 (GRCm39) V362A probably benign Het
Vmn2r87 T A 10: 130,307,712 (GRCm39) Y842F probably benign Het
Vps8 T A 16: 21,325,575 (GRCm39) probably benign Het
Other mutations in Cyp2j9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00826:Cyp2j9 APN 4 96,474,167 (GRCm39) missense possibly damaging 0.94
IGL01287:Cyp2j9 APN 4 96,471,665 (GRCm39) missense probably benign 0.03
R0032:Cyp2j9 UTSW 4 96,457,043 (GRCm39) missense possibly damaging 0.72
R0032:Cyp2j9 UTSW 4 96,457,043 (GRCm39) missense possibly damaging 0.72
R0525:Cyp2j9 UTSW 4 96,467,802 (GRCm39) critical splice acceptor site probably null
R1430:Cyp2j9 UTSW 4 96,472,201 (GRCm39) splice site probably benign
R1991:Cyp2j9 UTSW 4 96,460,201 (GRCm39) missense probably damaging 1.00
R2103:Cyp2j9 UTSW 4 96,460,201 (GRCm39) missense probably damaging 1.00
R2881:Cyp2j9 UTSW 4 96,462,249 (GRCm39) missense probably damaging 1.00
R4760:Cyp2j9 UTSW 4 96,457,028 (GRCm39) missense probably damaging 1.00
R4823:Cyp2j9 UTSW 4 96,456,972 (GRCm39) missense possibly damaging 0.79
R5782:Cyp2j9 UTSW 4 96,462,142 (GRCm39) missense probably benign 0.35
R5898:Cyp2j9 UTSW 4 96,465,951 (GRCm39) missense probably benign 0.44
R6259:Cyp2j9 UTSW 4 96,472,243 (GRCm39) missense probably benign 0.01
R6353:Cyp2j9 UTSW 4 96,474,135 (GRCm39) missense probably benign 0.00
R6663:Cyp2j9 UTSW 4 96,467,679 (GRCm39) missense probably benign 0.01
R7719:Cyp2j9 UTSW 4 96,457,079 (GRCm39) missense probably benign 0.00
R7915:Cyp2j9 UTSW 4 96,479,621 (GRCm39) start gained probably benign
R8832:Cyp2j9 UTSW 4 96,474,121 (GRCm39) missense probably benign 0.00
R8856:Cyp2j9 UTSW 4 96,462,184 (GRCm39) missense probably damaging 0.99
R8976:Cyp2j9 UTSW 4 96,479,399 (GRCm39) missense probably benign 0.00
R9497:Cyp2j9 UTSW 4 96,460,211 (GRCm39) nonsense probably null
R9649:Cyp2j9 UTSW 4 96,460,193 (GRCm39) missense probably damaging 0.98
RF020:Cyp2j9 UTSW 4 96,465,889 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCCCCTCATGCCATCAGTTTATTG -3'
(R):5'- CTACAGAGGAAGATGCTTGCTTCCC -3'

Sequencing Primer
(F):5'- CAGGAAATATGGCATCCTGCTTC -3'
(R):5'- tacacacacacacatacacacac -3'
Posted On 2013-04-24