Incidental Mutation 'R4009:Or10ag57'
| ID |
311587 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or10ag57
|
| Ensembl Gene |
ENSMUSG00000047594 |
| Gene Name |
olfactory receptor family 10 subfamily AG member 57 |
| Synonyms |
GA_x6K02T2Q125-48880078-48881058, Olfr1122, MOR264-1 |
| MMRRC Submission |
040846-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.113)
|
| Stock # |
R4009 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
87218051-87219031 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 87218924 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 292
(I292F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000149403
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056435]
[ENSMUST00000215371]
|
| AlphaFold |
Q8VGT9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000056435
AA Change: I292F
PolyPhen 2
Score 0.666 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000052190
Gene: ENSMUSG00000047594
AA Change: I292F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
43 |
319 |
6.3e-51 |
PFAM |
|
Pfam:7tm_1
|
53 |
302 |
5.8e-21 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000118646
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000215371
AA Change: I292F
PolyPhen 2
Score 0.666 (Sensitivity: 0.86; Specificity: 0.91)
|
| Meta Mutation Damage Score |
0.2009 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 93.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
A |
T |
11: 109,980,933 (GRCm39) |
L35Q |
probably damaging |
Het |
| Acss2 |
T |
A |
2: 155,399,548 (GRCm39) |
L529Q |
probably damaging |
Het |
| Apc2 |
T |
A |
10: 80,149,426 (GRCm39) |
D1464E |
probably benign |
Het |
| Atp8a2 |
A |
G |
14: 60,265,434 (GRCm39) |
S301P |
possibly damaging |
Het |
| Cntln |
A |
G |
4: 84,981,452 (GRCm39) |
T877A |
probably benign |
Het |
| Cntn6 |
T |
C |
6: 104,810,783 (GRCm39) |
I537T |
probably damaging |
Het |
| Cyp2d12 |
T |
G |
15: 82,440,493 (GRCm39) |
L94R |
probably damaging |
Het |
| Dnah7a |
A |
G |
1: 53,564,164 (GRCm39) |
L1965P |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,510,148 (GRCm39) |
N1560S |
probably damaging |
Het |
| F830045P16Rik |
A |
T |
2: 129,305,467 (GRCm39) |
N302K |
probably damaging |
Het |
| Fxr1 |
G |
T |
3: 34,119,171 (GRCm39) |
R580L |
probably benign |
Het |
| Gm5592 |
G |
T |
7: 40,938,934 (GRCm39) |
V739L |
probably benign |
Het |
| Gna13 |
A |
G |
11: 109,286,843 (GRCm39) |
D222G |
probably damaging |
Het |
| Grm7 |
T |
A |
6: 111,472,683 (GRCm39) |
Y841N |
probably damaging |
Het |
| Kat2b |
G |
A |
17: 53,951,769 (GRCm39) |
|
probably null |
Het |
| Kcng4 |
A |
G |
8: 120,352,824 (GRCm39) |
V362A |
probably damaging |
Het |
| Kcnh1 |
T |
A |
1: 191,959,448 (GRCm39) |
I334N |
probably benign |
Het |
| Mapkbp1 |
T |
C |
2: 119,854,086 (GRCm39) |
S1222P |
probably benign |
Het |
| Or10a3m |
A |
T |
7: 108,313,366 (GRCm39) |
I269L |
probably benign |
Het |
| Or11g26 |
T |
C |
14: 50,753,419 (GRCm39) |
S253P |
possibly damaging |
Het |
| Or5h24 |
G |
A |
16: 58,919,124 (GRCm39) |
T77I |
unknown |
Het |
| Pik3cb |
A |
G |
9: 98,922,982 (GRCm39) |
Y1017H |
probably damaging |
Het |
| Plpp5 |
A |
G |
8: 26,210,338 (GRCm39) |
E36G |
probably damaging |
Het |
| Pnma8a |
A |
T |
7: 16,695,301 (GRCm39) |
K385N |
probably damaging |
Het |
| Ptprd |
T |
G |
4: 75,874,634 (GRCm39) |
M1272L |
possibly damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,507,052 (GRCm39) |
I325V |
probably benign |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Skint4 |
T |
C |
4: 111,977,306 (GRCm39) |
V232A |
possibly damaging |
Het |
| Slc30a5 |
G |
A |
13: 100,945,741 (GRCm39) |
A537V |
probably damaging |
Het |
| Tcerg1 |
CAATTGAAAA |
CAA |
18: 42,697,201 (GRCm39) |
|
probably null |
Het |
| Tenm3 |
C |
A |
8: 48,802,258 (GRCm39) |
K162N |
probably damaging |
Het |
| Vmn2r44 |
T |
A |
7: 8,380,987 (GRCm39) |
Q302L |
possibly damaging |
Het |
| Zfp618 |
G |
A |
4: 63,051,801 (GRCm39) |
A861T |
probably benign |
Het |
|
| Other mutations in Or10ag57 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01783:Or10ag57
|
APN |
2 |
87,218,182 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01783:Or10ag57
|
APN |
2 |
87,218,187 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02396:Or10ag57
|
APN |
2 |
87,218,049 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL03338:Or10ag57
|
APN |
2 |
87,218,470 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03373:Or10ag57
|
APN |
2 |
87,218,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Or10ag57
|
UTSW |
2 |
87,218,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1245:Or10ag57
|
UTSW |
2 |
87,218,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1376:Or10ag57
|
UTSW |
2 |
87,218,162 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1376:Or10ag57
|
UTSW |
2 |
87,218,162 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1471:Or10ag57
|
UTSW |
2 |
87,218,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1681:Or10ag57
|
UTSW |
2 |
87,218,964 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1995:Or10ag57
|
UTSW |
2 |
87,218,175 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2246:Or10ag57
|
UTSW |
2 |
87,218,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2341:Or10ag57
|
UTSW |
2 |
87,218,084 (GRCm39) |
missense |
probably benign |
|
|
R4008:Or10ag57
|
UTSW |
2 |
87,218,924 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4011:Or10ag57
|
UTSW |
2 |
87,218,924 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4119:Or10ag57
|
UTSW |
2 |
87,218,187 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4547:Or10ag57
|
UTSW |
2 |
87,218,504 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4665:Or10ag57
|
UTSW |
2 |
87,218,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4666:Or10ag57
|
UTSW |
2 |
87,218,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Or10ag57
|
UTSW |
2 |
87,218,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4802:Or10ag57
|
UTSW |
2 |
87,218,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5049:Or10ag57
|
UTSW |
2 |
87,219,002 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5070:Or10ag57
|
UTSW |
2 |
87,218,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7594:Or10ag57
|
UTSW |
2 |
87,218,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7684:Or10ag57
|
UTSW |
2 |
87,218,372 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8064:Or10ag57
|
UTSW |
2 |
87,218,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8218:Or10ag57
|
UTSW |
2 |
87,218,922 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8282:Or10ag57
|
UTSW |
2 |
87,218,852 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8335:Or10ag57
|
UTSW |
2 |
87,218,204 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9800:Or10ag57
|
UTSW |
2 |
87,218,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGCAACGTTCTAAAACTGGC -3'
(R):5'- GGGCCCATTAACTGTACTTAGTCATAC -3'
Sequencing Primer
(F):5'- CAACATCTGGAGGGAGGTCTAAAGC -3'
(R):5'- CTGTACTTAGTCATACAAAGGTCAC -3'
|
| Posted On |
2015-04-29 |
Incidental Mutation