|Institutional Source||Beutler Lab|
|Gene Name||aldo-keto reductase family 1, member B8|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0384 (G1)|
|Chromosomal Location||34354119-34368463 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 34364330 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000040244 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038406]|
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
|Validation Efficiency||100% (72/72)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Akr1b8||
(F):5'- CAGCCTTGAGAGTGTCATGGAAGTG -3'
(R):5'- AGAAGTGGTCCTTGTTTGGTAACAGC -3'
(F):5'- GGGGGTCATTTACTCACGC -3'
(R):5'- ggagagatggctcagcg -3'