Incidental Mutation 'R4011:Olfr110'
ID311713
Institutional Source Beutler Lab
Gene Symbol Olfr110
Ensembl Gene ENSMUSG00000090894
Gene Nameolfactory receptor 110
SynonymsGA_x6K02T2PSCP-1956307-1957260, MOR249-2
MMRRC Submission 040948-MU
Accession Numbers

Genbank: NM_146328.2

Is this an essential gene? Probably non essential (E-score: 0.212) question?
Stock #R4011 (G1)
Quality Score225
Status Validated
Chromosome17
Chromosomal Location37492468-37500207 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 37499491 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 280 (V280A)
Ref Sequence ENSEMBL: ENSMUSP00000149213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168318] [ENSMUST00000216472]
Predicted Effect possibly damaging
Transcript: ENSMUST00000168318
AA Change: V280A

PolyPhen 2 Score 0.790 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000131089
Gene: ENSMUSG00000090894
AA Change: V280A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 8.9e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 286 1.9e-6 PFAM
Pfam:7tm_1 41 290 1.2e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216472
AA Change: V280A

PolyPhen 2 Score 0.790 (Sensitivity: 0.85; Specificity: 0.93)
Meta Mutation Damage Score 0.2403 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G A 11: 9,622,013 probably benign Het
Acss2 T A 2: 155,557,628 L529Q probably damaging Het
Adsl T C 15: 80,966,156 S359P probably benign Het
C1qtnf1 G A 11: 118,446,539 G65D probably benign Het
Chd1l A T 3: 97,570,402 M679K probably benign Het
Cspg4 A G 9: 56,887,317 T779A probably benign Het
Ddx18 T C 1: 121,562,081 I200V probably benign Het
Dnah9 T A 11: 65,834,464 M4288L probably damaging Het
F830045P16Rik A T 2: 129,463,547 N302K probably damaging Het
Gas1 T G 13: 60,175,977 D322A unknown Het
Gfm2 T A 13: 97,143,100 probably benign Het
Gm11487 T C 4: 73,401,810 Y244C probably damaging Het
Gm5592 G T 7: 41,289,510 V739L probably benign Het
Hbb-bh2 T A 7: 103,840,209 H45L probably benign Het
Ifit2 G T 19: 34,574,045 M328I probably benign Het
Igdcc4 T C 9: 65,135,479 V1237A probably benign Het
Kat2b G A 17: 53,644,741 probably null Het
Lmtk2 A G 5: 144,175,879 N1139S probably benign Het
Map1a G A 2: 121,300,127 A475T probably damaging Het
Map3k20 G A 2: 72,384,124 probably benign Het
Mga T C 2: 119,931,780 V1084A probably damaging Het
Myo3b A G 2: 70,096,376 I5V probably benign Het
Olfr1118 A G 2: 87,309,211 I141V probably benign Het
Olfr1122 A T 2: 87,388,580 I292F possibly damaging Het
Olfr192 G A 16: 59,098,761 T77I unknown Het
Olfr512 A T 7: 108,714,159 I269L probably benign Het
Olfr657 A G 7: 104,636,348 T225A probably benign Het
Osmr G T 15: 6,824,533 R565S probably benign Het
Pcolce G T 5: 137,605,774 Q344K probably benign Het
Prdm11 A G 2: 93,012,830 F95L probably damaging Het
Psd2 C T 18: 35,987,247 T383I probably benign Het
Reg3a G A 6: 78,383,570 D164N probably damaging Het
Serpina3a A T 12: 104,118,643 D99V probably benign Het
Sgce G T 6: 4,691,563 Y301* probably null Het
Slc28a3 T C 13: 58,566,250 K434E probably benign Het
Slc30a3 A G 5: 31,086,859 F360L probably damaging Het
Tdpoz3 A T 3: 93,826,243 Y75F possibly damaging Het
Trim65 A G 11: 116,127,703 F249L probably benign Het
Tubgcp3 A T 8: 12,639,634 L544* probably null Het
Vit C T 17: 78,534,692 probably benign Het
Wdfy4 C A 14: 33,102,680 probably benign Het
Xpo6 T C 7: 126,140,608 K431E probably benign Het
Xrn1 T A 9: 95,985,225 Y545* probably null Het
Other mutations in Olfr110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01954:Olfr110 APN 17 37498649 utr 5 prime probably benign
IGL03088:Olfr110 APN 17 37498648 utr 5 prime probably benign
F5426:Olfr110 UTSW 17 37499536 missense probably damaging 1.00
R1664:Olfr110 UTSW 17 37499425 missense possibly damaging 0.83
R2883:Olfr110 UTSW 17 37499380 missense probably damaging 1.00
R4365:Olfr110 UTSW 17 37499379 missense probably damaging 1.00
R4989:Olfr110 UTSW 17 37499126 missense probably benign 0.10
R5442:Olfr110 UTSW 17 37499439 missense probably damaging 1.00
R5577:Olfr110 UTSW 17 37499602 missense probably benign 0.02
R6592:Olfr110 UTSW 17 37499097 missense probably damaging 1.00
R7134:Olfr110 UTSW 17 37498885 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATAGGCTGGACTCCTTTCCTG -3'
(R):5'- ACCAGCAACAACTGAGTGG -3'

Sequencing Primer
(F):5'- TACATCATCTCCACCATCCTGAGG -3'
(R):5'- TGTTGATCACACATAAGAGAG -3'
Posted On2015-04-29