|Institutional Source||Beutler Lab|
|Gene Name||Eph receptor A4|
|Synonyms||rb, Sek, Sek1, 2900005C20Rik, Cek8, Hek8, Tyro1|
|Is this an essential gene?||Probably essential (E-score: 0.926)|
|Stock #||R4012 (G1)|
|Chromosomal Location||77367185-77515088 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 77390094 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000140408 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027451] [ENSMUST00000188797] [ENSMUST00000188952] [ENSMUST00000190149]|
|Coding Region Coverage||
|Validation Efficiency||100% (79/79)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
PHENOTYPE: Mutants are known for their "hopping gait". Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections. Heterozygotes show less severe phenotype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Epha4||
(F):5'- TTGCACCTTGACAGCCTTG -3'
(R):5'- TGATGGCTTCAGCTCTTCAC -3'
(F):5'- CTTGACAGCCTTGACGAATG -3'
(R):5'- TTCACCCCGACTCAACAGAGATTAC -3'