Incidental Mutation 'R4013:Tas2r116'
ID311815
Institutional Source Beutler Lab
Gene Symbol Tas2r116
Ensembl Gene ENSMUSG00000030194
Gene Nametaste receptor, type 2, member 116
Synonymsmt2r56, Tas2r7, T2R16, mGR16, TRB1, Tas2r16, Tas2r14, TRB4
MMRRC Submission 040950-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R4013 (G1)
Quality Score225
Status Validated
Chromosome6
Chromosomal Location132855438-132856355 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 132856267 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Arginine at position 277 (H277R)
Ref Sequence ENSEMBL: ENSMUSP00000032315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032315]
Predicted Effect probably damaging
Transcript: ENSMUST00000032315
AA Change: H277R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000032315
Gene: ENSMUSG00000030194
AA Change: H277R

DomainStartEndE-ValueType
Pfam:TAS2R 1 300 2.8e-89 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203358
Meta Mutation Damage Score 0.7311 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 92.4%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 46,018,680 Q168R probably benign Het
Adgrg3 A G 8: 95,035,099 probably benign Het
Apold1 A G 6: 134,983,906 I108V probably benign Het
Atp6v0a2 G A 5: 124,712,796 V429M probably damaging Het
Cbln4 A T 2: 172,037,557 M137K probably damaging Het
Cfap57 A G 4: 118,593,143 V594A probably benign Het
Chd9 A G 8: 90,973,169 E28G possibly damaging Het
Clip4 T A 17: 71,856,546 C704* probably null Het
Col8a2 T A 4: 126,311,115 probably benign Het
Cyp3a59 A G 5: 146,079,383 T17A probably benign Het
Cyp4f14 G A 17: 32,916,879 Q3* probably null Het
Cysltr2 A G 14: 73,029,565 I235T probably damaging Het
Esp34 C A 17: 38,559,555 C45* probably null Het
Gabrg2 T C 11: 41,971,880 K126E possibly damaging Het
Gm4846 A C 1: 166,494,680 probably null Het
Igsf21 T C 4: 140,037,469 N165S possibly damaging Het
Kcnf1 A G 12: 17,175,993 F76L probably benign Het
Kcns1 A G 2: 164,168,257 V194A probably damaging Het
Kdm5a T A 6: 120,394,106 Y504N probably damaging Het
Kdm5b A G 1: 134,627,329 Y1325C possibly damaging Het
Kif1a T C 1: 93,076,292 D156G probably damaging Het
Lrp1b A G 2: 40,802,984 F3401L possibly damaging Het
Lrrc63 A G 14: 75,098,291 Y460H probably damaging Het
Myo15b G T 11: 115,871,456 E1201* probably null Het
Ndor1 A T 2: 25,250,150 I84K probably damaging Het
Ndst4 T A 3: 125,683,170 Y15N probably damaging Het
Olfr1019 A G 2: 85,841,381 S137P probably damaging Het
Olfr609 T C 7: 103,492,633 T82A probably benign Het
Pik3r6 T A 11: 68,533,521 D317E possibly damaging Het
Ppp2r1a G A 17: 20,951,347 R28H probably damaging Het
Ptch1 T G 13: 63,524,959 E944A probably benign Het
Ptpn12 G A 5: 20,992,743 P700L probably benign Het
Setx GTGGCT GT 2: 29,154,061 probably null Het
Slc39a13 T C 2: 91,064,902 probably null Het
Smarca2 G A 19: 26,683,927 probably null Het
Taok1 A T 11: 77,559,833 L371H possibly damaging Het
Treml4 G A 17: 48,264,809 R80Q probably benign Het
Trim9 G A 12: 70,346,352 H273Y probably damaging Het
Tyr A G 7: 87,437,940 S455P probably benign Het
Vmn1r214 G A 13: 23,035,350 C338Y probably benign Het
Vmn2r52 G A 7: 10,170,676 T412I probably benign Het
Wdr70 A T 15: 8,079,214 C149* probably null Het
Wdr93 T A 7: 79,768,411 V294E possibly damaging Het
Other mutations in Tas2r116
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01305:Tas2r116 APN 6 132855443 missense probably benign 0.02
IGL01656:Tas2r116 APN 6 132855433 unclassified probably benign
IGL01970:Tas2r116 APN 6 132855669 missense probably benign 0.07
ANU22:Tas2r116 UTSW 6 132855443 missense probably benign 0.02
R0490:Tas2r116 UTSW 6 132856021 missense probably benign 0.02
R2422:Tas2r116 UTSW 6 132855594 missense possibly damaging 0.88
R4516:Tas2r116 UTSW 6 132856150 missense probably damaging 1.00
R4745:Tas2r116 UTSW 6 132855705 missense probably benign 0.14
R4842:Tas2r116 UTSW 6 132855697 missense probably benign 0.00
R7723:Tas2r116 UTSW 6 132855904 missense probably benign 0.25
Z1088:Tas2r116 UTSW 6 132855948 missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CAGAGATGCCAGCACTAAGG -3'
(R):5'- AAGCCATATGTGTAACCATATTCCCTG -3'

Sequencing Primer
(F):5'- TAAGGCCCACATCAGAGCCTTG -3'
(R):5'- CTACAAAGACTAGAAGATGCATAGAC -3'
Posted On2015-04-29