Mutagenetix > Incidental Mutation

Incidental Mutation 'R4014:Vmn2r103'

311885

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

040951-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R4014 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19793604 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 219 (I219M)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172203
AA Change: I219M

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: I219M

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 93.6%

Validation Efficiency

100% (49/49)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc2	A	T	19: 43,823,120	Q1008L	probably benign	Het
Adgrg7	A	G	16: 56,742,288	F562S	probably damaging	Het
Alms1	T	A	6: 85,678,352	N3293K	probably benign	Het
Cdk20	T	A	13: 64,437,505	V201D	probably benign	Het
Cenpf	A	G	1: 189,653,159	V2308A	probably benign	Het
Chek1	T	C	9: 36,722,754		probably benign	Het
Ciz1	G	T	2: 32,374,344	E497D	probably damaging	Het
Clcn6	A	G	4: 148,017,610	F339S	probably damaging	Het
Dctpp1	G	A	7: 127,257,113	R146C	probably damaging	Het
Dennd5a	C	T	7: 109,935,481		probably null	Het
Dmxl1	G	A	18: 49,863,962	V442I	probably benign	Het
Dmxl2	C	A	9: 54,378,709		probably null	Het
Dnah11	A	G	12: 117,974,914	I3273T	probably benign	Het
Dnhd1	T	A	7: 105,714,838	D4132E	probably damaging	Het
Dst	G	A	1: 34,191,282	W2327*	probably null	Het
Epb41	A	T	4: 131,982,445		probably benign	Het
Frem2	C	T	3: 53,652,353	V1578I	probably benign	Het
Fsip2	A	G	2: 82,983,518	T3394A	probably benign	Het
Gabra5	C	T	7: 57,489,010	D97N	probably damaging	Het
Habp2	A	G	19: 56,319,622	E546G	probably benign	Het
Hace1	A	G	10: 45,588,374		probably benign	Het
Herc4	T	C	10: 63,287,544	S433P	probably benign	Het
Igf2bp2	T	C	16: 22,063,676	N425S	probably damaging	Het
Krt26	C	T	11: 99,335,302	G189S	probably damaging	Het
Lama2	A	T	10: 26,984,376	D3038E	probably damaging	Het
Lmbrd2	T	C	15: 9,151,585		probably benign	Het
Lrp1b	A	G	2: 40,802,984	F3401L	possibly damaging	Het
Map2k7	T	A	8: 4,247,663	S421R	possibly damaging	Het
Matn1	A	G	4: 130,951,947	Q304R	possibly damaging	Het
Muc4	C	T	16: 32,755,273		probably benign	Het
Muc5b	G	A	7: 141,863,630	V3438M	probably benign	Het
Myo3a	A	G	2: 22,578,170	R479G	possibly damaging	Het
Mzf1	A	G	7: 13,043,956	V586A	possibly damaging	Het
Olfr1016	A	T	2: 85,799,476	Y265N	probably damaging	Het
Olfr834	T	C	9: 18,988,882	V298A	probably benign	Het
Pcdhgb7	A	T	18: 37,752,363	E195D	probably benign	Het
Pde4b	A	G	4: 102,555,625	D199G	probably benign	Het
Rnf213	C	T	11: 119,445,729	Q3309*	probably null	Het
Setx	GTGGCT	GT	2: 29,154,061	1814	probably null	Het
Slc22a4	C	G	11: 53,997,392	C270S	probably benign	Het
Smarca2	G	A	19: 26,683,927		probably null	Het
Spata31d1c	T	C	13: 65,035,399	S252P	probably damaging	Het
Tyr	A	G	7: 87,437,940	S455P	probably benign	Het
Urb1	A	T	16: 90,769,465	M1478K	probably damaging	Het
Usp1	A	G	4: 98,934,702	D751G	probably damaging	Het
Vmn1r214	G	A	13: 23,035,350	C338Y	probably benign	Het
Wwp2	A	G	8: 107,485,621	N139S	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19811659	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19793765	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19799263	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19812213	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- TGTAATCCAGTAAGTCCTTGAGAC -3'
(R):5'- TACCTTCTAGGGAATCAACATCTC -3'

Sequencing Primer
(F):5'- ATATCCCATTAAAATGTTCTCCTGTC -3'
(R):5'- TCTAGGGAATCAACATCTCCATAAAC -3'

Posted On

2015-04-29