Incidental Mutation 'R4015:Cfap161'
ID |
311905 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cfap161
|
Ensembl Gene |
ENSMUSG00000011154 |
Gene Name |
cilia and flagella associated protein 161 |
Synonyms |
1700026D08Rik |
MMRRC Submission |
040952-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.068)
|
Stock # |
R4015 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
83423309-83444088 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 83429479 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glycine to Serine
at position 180
(G180S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000114051
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000011298]
[ENSMUST00000119134]
[ENSMUST00000149671]
|
AlphaFold |
Q6P8Y0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000011298
AA Change: G180S
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000119134
AA Change: G180S
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000149671
AA Change: G155S
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208785
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 93.5%
|
Validation Efficiency |
97% (38/39) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcb6 |
C |
T |
1: 75,151,135 (GRCm39) |
|
probably null |
Het |
Cacna1e |
T |
C |
1: 154,358,331 (GRCm39) |
D580G |
probably damaging |
Het |
Ccdc66 |
A |
G |
14: 27,205,793 (GRCm39) |
I898T |
probably damaging |
Het |
Celf3 |
T |
C |
3: 94,394,505 (GRCm39) |
V202A |
probably benign |
Het |
Col5a2 |
T |
C |
1: 45,442,631 (GRCm39) |
I605V |
probably benign |
Het |
Coq6 |
A |
G |
12: 84,413,671 (GRCm39) |
H67R |
probably benign |
Het |
Cyp2b19 |
T |
C |
7: 26,461,768 (GRCm39) |
F196S |
probably damaging |
Het |
Cyp4a14 |
G |
T |
4: 115,348,331 (GRCm39) |
P382Q |
probably damaging |
Het |
Dctpp1 |
G |
A |
7: 126,856,285 (GRCm39) |
R146C |
probably damaging |
Het |
Ddias |
T |
C |
7: 92,509,069 (GRCm39) |
K282R |
probably benign |
Het |
Dnah10 |
A |
G |
5: 124,854,990 (GRCm39) |
Q1965R |
probably benign |
Het |
Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably null |
Het |
Igf2bp2 |
T |
C |
16: 21,882,426 (GRCm39) |
N425S |
probably damaging |
Het |
Lrp1b |
A |
G |
2: 40,692,996 (GRCm39) |
F3401L |
possibly damaging |
Het |
Mocs2 |
T |
C |
13: 114,957,334 (GRCm39) |
|
probably benign |
Het |
Muc5b |
G |
A |
7: 141,417,367 (GRCm39) |
V3438M |
probably benign |
Het |
Myo3a |
A |
G |
2: 22,468,182 (GRCm39) |
R479G |
possibly damaging |
Het |
Nalcn |
T |
G |
14: 123,723,799 (GRCm39) |
E422A |
probably damaging |
Het |
Pcdh17 |
T |
C |
14: 84,684,547 (GRCm39) |
V338A |
probably damaging |
Het |
Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
Rbm12b1 |
T |
C |
4: 12,145,491 (GRCm39) |
S488P |
probably benign |
Het |
Setx |
GTGGCT |
GT |
2: 29,044,073 (GRCm39) |
1814 |
probably null |
Het |
Srcap |
C |
A |
7: 127,124,595 (GRCm39) |
P255Q |
probably benign |
Het |
Sult6b2 |
T |
A |
6: 142,735,988 (GRCm39) |
N202I |
possibly damaging |
Het |
Tcf7l1 |
A |
G |
6: 72,613,382 (GRCm39) |
|
probably benign |
Het |
Tef |
T |
C |
15: 81,707,806 (GRCm39) |
V261A |
probably damaging |
Het |
Trio |
C |
T |
15: 27,744,187 (GRCm39) |
V2582I |
possibly damaging |
Het |
Tyr |
A |
G |
7: 87,087,148 (GRCm39) |
S455P |
probably benign |
Het |
Uggt2 |
T |
C |
14: 119,263,845 (GRCm39) |
N1062D |
possibly damaging |
Het |
Unc13b |
G |
A |
4: 43,237,801 (GRCm39) |
G3441R |
probably damaging |
Het |
Vmn1r214 |
G |
A |
13: 23,219,520 (GRCm39) |
C338Y |
probably benign |
Het |
Wdr70 |
A |
T |
15: 8,108,698 (GRCm39) |
C149* |
probably null |
Het |
Zfp867 |
A |
G |
11: 59,354,520 (GRCm39) |
F270L |
probably damaging |
Het |
|
Other mutations in Cfap161 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01827:Cfap161
|
APN |
7 |
83,442,648 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL01999:Cfap161
|
APN |
7 |
83,440,899 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02291:Cfap161
|
APN |
7 |
83,440,847 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02444:Cfap161
|
APN |
7 |
83,425,353 (GRCm39) |
missense |
probably damaging |
1.00 |
R0492:Cfap161
|
UTSW |
7 |
83,443,245 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0652:Cfap161
|
UTSW |
7 |
83,442,484 (GRCm39) |
missense |
probably null |
0.01 |
R1599:Cfap161
|
UTSW |
7 |
83,425,287 (GRCm39) |
missense |
possibly damaging |
0.84 |
R1828:Cfap161
|
UTSW |
7 |
83,440,932 (GRCm39) |
critical splice acceptor site |
probably null |
|
R2117:Cfap161
|
UTSW |
7 |
83,425,184 (GRCm39) |
missense |
possibly damaging |
0.63 |
R2262:Cfap161
|
UTSW |
7 |
83,442,580 (GRCm39) |
missense |
probably benign |
0.37 |
R3618:Cfap161
|
UTSW |
7 |
83,429,390 (GRCm39) |
nonsense |
probably null |
|
R5821:Cfap161
|
UTSW |
7 |
83,425,188 (GRCm39) |
missense |
probably benign |
0.38 |
R6477:Cfap161
|
UTSW |
7 |
83,443,230 (GRCm39) |
nonsense |
probably null |
|
R6478:Cfap161
|
UTSW |
7 |
83,442,484 (GRCm39) |
missense |
probably benign |
0.00 |
R7108:Cfap161
|
UTSW |
7 |
83,442,518 (GRCm39) |
missense |
possibly damaging |
0.60 |
R7203:Cfap161
|
UTSW |
7 |
83,425,258 (GRCm39) |
missense |
probably damaging |
0.97 |
R7582:Cfap161
|
UTSW |
7 |
83,426,290 (GRCm39) |
missense |
possibly damaging |
0.69 |
R8714:Cfap161
|
UTSW |
7 |
83,442,482 (GRCm39) |
missense |
probably benign |
0.11 |
R8762:Cfap161
|
UTSW |
7 |
83,443,282 (GRCm39) |
missense |
possibly damaging |
0.92 |
R9587:Cfap161
|
UTSW |
7 |
83,440,878 (GRCm39) |
missense |
probably damaging |
1.00 |
R9665:Cfap161
|
UTSW |
7 |
83,442,579 (GRCm39) |
missense |
probably benign |
0.00 |
R9702:Cfap161
|
UTSW |
7 |
83,442,652 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TTGGAGCTACAGTGAGCCTCTG -3'
(R):5'- ACATATTCCTGTGAGCTGTGC -3'
Sequencing Primer
(F):5'- CTTGACTGGCAGCTGTGAGC -3'
(R):5'- CTTTCTCATAGGATGGGTAGGAACAG -3'
|
Posted On |
2015-04-29 |