Incidental Mutation 'R3962:Oasl2'
ID 312122
Institutional Source Beutler Lab
Gene Symbol Oasl2
Ensembl Gene ENSMUSG00000029561
Gene Name 2'-5' oligoadenylate synthetase-like 2
Synonyms M1204, Mmu-OASL
MMRRC Submission 040837-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3962 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 115034997-115050295 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115035808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 28 (D28G)
Ref Sequence ENSEMBL: ENSMUSP00000117795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031542] [ENSMUST00000124716] [ENSMUST00000146072] [ENSMUST00000150361]
AlphaFold Q9Z2F2
Predicted Effect probably benign
Transcript: ENSMUST00000031542
AA Change: D28G

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000031542
Gene: ENSMUSG00000029561
AA Change: D28G

DomainStartEndE-ValueType
low complexity region 63 73 N/A INTRINSIC
Pfam:OAS1_C 169 351 8.4e-77 PFAM
SCOP:d1euvb_ 355 427 4e-4 SMART
Blast:UBQ 355 430 9e-30 BLAST
UBQ 435 506 8.88e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000124716
SMART Domains Protein: ENSMUSP00000115070
Gene: ENSMUSG00000029561

DomainStartEndE-ValueType
Pfam:OAS1_C 1 131 1.2e-48 PFAM
SCOP:d1euvb_ 135 207 6e-5 SMART
Blast:UBQ 135 210 9e-32 BLAST
Blast:UBQ 215 240 5e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137828
Predicted Effect unknown
Transcript: ENSMUST00000144064
AA Change: D2G
Predicted Effect probably benign
Transcript: ENSMUST00000146072
AA Change: D28G

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000117795
Gene: ENSMUSG00000029561
AA Change: D28G

DomainStartEndE-ValueType
PDB:1PX5|B 6 101 4e-10 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000150361
AA Change: D28G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000119042
Gene: ENSMUSG00000029561
AA Change: D28G

DomainStartEndE-ValueType
PDB:1PX5|B 6 140 3e-13 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201919
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201445
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency 96% (48/50)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,838,803 (GRCm39) T595A possibly damaging Het
Abca12 A T 1: 71,313,674 (GRCm39) probably null Het
Ablim2 C T 5: 35,969,519 (GRCm39) R211C probably damaging Het
Actn4 C A 7: 28,597,647 (GRCm39) probably null Het
B3gnt5 A G 16: 19,587,798 (GRCm39) S6G probably benign Het
Bod1l T G 5: 41,966,064 (GRCm39) E2667A probably benign Het
Ccdc13 G A 9: 121,628,005 (GRCm39) probably benign Het
Ccdc15 G T 9: 37,231,782 (GRCm39) R181S probably damaging Het
Ccnd1 G A 7: 144,487,787 (GRCm39) T230M probably damaging Het
Cdcp1 T C 9: 123,011,446 (GRCm39) T344A possibly damaging Het
Fam161a T C 11: 22,973,507 (GRCm39) M275T possibly damaging Het
Fbxo15 A G 18: 84,977,372 (GRCm39) T95A probably benign Het
Fndc5 T C 4: 129,033,688 (GRCm39) V152A probably benign Het
Galk2 A T 2: 125,735,293 (GRCm39) N107I probably benign Het
Glmn A T 5: 107,708,911 (GRCm39) probably benign Het
Gm5082 T C 13: 41,809,894 (GRCm39) noncoding transcript Het
Gm5828 C T 1: 16,838,868 (GRCm39) noncoding transcript Het
Haus6 C T 4: 86,530,041 (GRCm39) A4T possibly damaging Het
Hmgcs2 G A 3: 98,198,354 (GRCm39) V86M possibly damaging Het
Hrg G A 16: 22,774,825 (GRCm39) V152I possibly damaging Het
Itga2 A T 13: 114,976,054 (GRCm39) V1106E probably damaging Het
Itga9 G A 9: 118,457,254 (GRCm39) D122N possibly damaging Het
Kif21a T A 15: 90,869,612 (GRCm39) E413V probably damaging Het
Klk1 A G 7: 43,878,973 (GRCm39) T256A possibly damaging Het
L1td1 T C 4: 98,625,686 (GRCm39) V627A probably benign Het
Larp4 C A 15: 99,910,026 (GRCm39) Q652K probably damaging Het
Ltbp3 G A 19: 5,804,050 (GRCm39) R854Q probably benign Het
Minar1 G A 9: 89,483,963 (GRCm39) T478I probably damaging Het
Moxd2 T A 6: 40,862,331 (GRCm39) M163L probably benign Het
Myo15a G A 11: 60,370,654 (GRCm39) R1138H probably benign Het
Or6c207 A T 10: 129,104,535 (GRCm39) I219N probably damaging Het
Platr26 A T 2: 71,549,849 (GRCm39) noncoding transcript Het
Ptdss1 A G 13: 67,142,075 (GRCm39) H411R probably benign Het
Ptpra A G 2: 30,325,672 (GRCm39) T147A probably damaging Het
Rfx2 T C 17: 57,092,302 (GRCm39) Y307C probably damaging Het
Rtn3 T C 19: 7,435,510 (GRCm39) S142G probably damaging Het
Shisa6 A G 11: 66,108,302 (GRCm39) V525A probably damaging Het
Slc4a3 A G 1: 75,533,398 (GRCm39) S1007G probably damaging Het
Spmip5 A G 19: 58,777,541 (GRCm39) Y82H probably damaging Het
Srsf3 C T 17: 29,255,430 (GRCm39) probably benign Het
Taar8a A G 10: 23,953,054 (GRCm39) I219M probably damaging Het
Tars2 A G 3: 95,662,068 (GRCm39) probably null Het
Tfap2d A G 1: 19,189,189 (GRCm39) N245S probably damaging Het
Tlr6 T A 5: 65,112,328 (GRCm39) H193L probably benign Het
Tomm20l T C 12: 71,164,352 (GRCm39) V78A probably benign Het
Tsc2 G A 17: 24,840,140 (GRCm39) probably benign Het
Usp2 A G 9: 43,986,954 (GRCm39) D84G possibly damaging Het
V1ra8 A G 6: 90,180,466 (GRCm39) N223S probably benign Het
Wnk2 C A 13: 49,224,453 (GRCm39) R1122L probably damaging Het
Other mutations in Oasl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02054:Oasl2 APN 5 115,035,867 (GRCm39) missense probably damaging 1.00
IGL02649:Oasl2 APN 5 115,035,753 (GRCm39) missense probably damaging 1.00
IGL02810:Oasl2 APN 5 115,035,852 (GRCm39) missense probably damaging 1.00
IGL03153:Oasl2 APN 5 115,039,393 (GRCm39) missense probably benign 0.02
R0179:Oasl2 UTSW 5 115,048,973 (GRCm39) missense probably benign
R1318:Oasl2 UTSW 5 115,039,442 (GRCm39) missense probably benign 0.01
R1831:Oasl2 UTSW 5 115,039,367 (GRCm39) missense probably benign 0.00
R1941:Oasl2 UTSW 5 115,049,423 (GRCm39) utr 3 prime probably benign
R2068:Oasl2 UTSW 5 115,049,298 (GRCm39) missense probably benign 0.01
R2104:Oasl2 UTSW 5 115,049,063 (GRCm39) nonsense probably null
R2170:Oasl2 UTSW 5 115,044,861 (GRCm39) missense probably damaging 0.99
R2437:Oasl2 UTSW 5 115,049,357 (GRCm39) missense probably benign
R2882:Oasl2 UTSW 5 115,049,084 (GRCm39) missense probably damaging 1.00
R3960:Oasl2 UTSW 5 115,043,098 (GRCm39) missense probably benign 0.03
R4609:Oasl2 UTSW 5 115,037,857 (GRCm39) missense possibly damaging 0.47
R4761:Oasl2 UTSW 5 115,037,836 (GRCm39) missense probably benign 0.00
R5242:Oasl2 UTSW 5 115,043,122 (GRCm39) missense possibly damaging 0.92
R5691:Oasl2 UTSW 5 115,037,828 (GRCm39) missense possibly damaging 0.93
R6594:Oasl2 UTSW 5 115,044,836 (GRCm39) missense probably benign 0.30
R7053:Oasl2 UTSW 5 115,049,291 (GRCm39) missense possibly damaging 0.82
R7062:Oasl2 UTSW 5 115,049,152 (GRCm39) nonsense probably null
R7688:Oasl2 UTSW 5 115,035,909 (GRCm39) missense probably benign 0.01
R7753:Oasl2 UTSW 5 115,043,118 (GRCm39) missense probably benign
R8026:Oasl2 UTSW 5 115,040,329 (GRCm39) unclassified probably benign
R8160:Oasl2 UTSW 5 115,039,347 (GRCm39) unclassified probably benign
R8479:Oasl2 UTSW 5 115,035,852 (GRCm39) missense probably damaging 1.00
R9429:Oasl2 UTSW 5 115,043,040 (GRCm39) missense probably benign
R9585:Oasl2 UTSW 5 115,035,901 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTCCAGTTTCTCCAAGGAGGG -3'
(R):5'- ATGGCCCACCTCTCAAGTTC -3'

Sequencing Primer
(F):5'- AGGGGCAGAGCGCTTTTC -3'
(R):5'- GTTCACAAGCCCCACAGG -3'
Posted On 2015-04-29