Mutagenetix > Incidental Mutation

Incidental Mutation 'R3963:Fpr-rs6'

312212

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs6

Ensembl Gene

ENSMUSG00000071275

Gene Name

formyl peptide receptor, related sequence 6

Synonyms

MMRRC Submission

040932-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

R3963 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20182078-20183097 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20182217 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 294 (P294L)

Ref Sequence

ENSEMBL: ENSMUSP00000093296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095636]

AlphaFold

Q3SXG2

Predicted Effect

probably damaging
Transcript: ENSMUST00000095636
AA Change: P294L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000093296
Gene: ENSMUSG00000071275
AA Change: P294L

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	5.7e-38	PFAM

Meta Mutation Damage Score

0.9282

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.8%

Validation Efficiency

100% (61/61)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A830010M20Rik	G	A	5: 107,507,356	C1007Y	probably damaging	Het
Adamts18	T	C	8: 113,777,811	D59G	probably benign	Het
AF529169	G	A	9: 89,601,910	T478I	probably damaging	Het
Ank2	A	T	3: 126,934,596	S783T	probably benign	Het
Arfgef3	T	C	10: 18,592,277	D1725G	probably damaging	Het
B3gnt5	A	G	16: 19,769,048	S6G	probably benign	Het
Ccdc82	C	A	9: 13,252,386	T101K	possibly damaging	Het
Ccdc85a	A	C	11: 28,576,396	M376R	probably benign	Het
Cd200r1	T	A	16: 44,792,795	C255S	probably benign	Het
Cdc23	T	C	18: 34,646,919	M119V	probably benign	Het
Cers3	G	T	7: 66,786,075	A261S	probably benign	Het
Clptm1	C	T	7: 19,638,196	W238*	probably null	Het
Cr2	A	G	1: 195,159,739	V302A	probably damaging	Het
Cyp4a31	A	G	4: 115,574,772		probably benign	Het
Dennd4a	T	A	9: 64,862,331	I440N	probably damaging	Het
Dsc2	C	T	18: 20,051,227	V35I	probably damaging	Het
Dyrk1a	T	A	16: 94,663,746	M71K	probably benign	Het
Exoc3l2	G	A	7: 19,495,256	G200S	probably benign	Het
Fam160b1	T	C	19: 57,373,010	L122P	possibly damaging	Het
Fkbp15	A	T	4: 62,340,677	I114N	probably damaging	Het
Frmd6	A	G	12: 70,893,864	T428A	probably benign	Het
G6pd2	T	A	5: 61,808,885	M1K	probably null	Het
Gdf3	C	T	6: 122,606,758	V217I	probably benign	Het
Grm7	G	T	6: 110,646,348	V161F	probably damaging	Het
Gtf3c1	T	C	7: 125,693,225		probably null	Het
Hrg	G	A	16: 22,956,075	V152I	possibly damaging	Het
Itpkc	T	C	7: 27,227,509	T327A	probably damaging	Het
Jade1	T	C	3: 41,601,410	V304A	probably damaging	Het
Leo1	C	A	9: 75,450,480		probably benign	Het
Lrrc7	A	T	3: 158,160,405	L1233Q	probably damaging	Het
Ltbp3	G	A	19: 5,754,022	R854Q	probably benign	Het
Matn2	C	A	15: 34,388,791	Y342*	probably null	Het
Mlh3	T	C	12: 85,268,680	H244R	possibly damaging	Het
Mmaa	A	T	8: 79,268,214	V321E	probably damaging	Het
Ntng1	T	A	3: 109,934,868	L196F	probably damaging	Het
Oas1e	A	G	5: 120,794,140	V146A	probably damaging	Het
Olfr67	G	T	7: 103,788,034	T81K	probably benign	Het
Plcxd2	T	C	16: 45,980,501	K120R	probably damaging	Het
Prex2	G	T	1: 11,110,357	C382F	possibly damaging	Het
Psg29	T	A	7: 17,208,585	H170Q	probably benign	Het
Ptprk	A	G	10: 28,551,665	T747A	probably damaging	Het
Qk	G	A	17: 10,216,465		probably benign	Het
Rpusd2	A	G	2: 119,038,604	T503A	probably benign	Het
Rtn3	T	C	19: 7,458,145	S142G	probably damaging	Het
Slco1a5	C	T	6: 142,248,644		probably null	Het
Snap91	A	T	9: 86,775,612	W509R	probably damaging	Het
Srsf3	C	T	17: 29,036,456		probably benign	Het
Tmem267	A	T	13: 119,492,639		probably null	Het
Tmem63a	G	A	1: 180,963,114	D446N	possibly damaging	Het
Tnfaip8	C	A	18: 50,090,586	H154N	possibly damaging	Het
Trim35	T	C	14: 66,304,054	L209P	probably damaging	Het
Ttf1	A	G	2: 29,064,804	E60G	possibly damaging	Het
Ttf2	T	C	3: 100,941,820		probably benign	Het
Tubg2	T	C	11: 101,160,398		probably null	Het
Ubap1l	C	T	9: 65,369,195		probably benign	Het
Usp48	A	T	4: 137,633,439	R26*	probably null	Het
Vmn1r222	A	G	13: 23,232,932	V37A	probably benign	Het
Vmn2r4	T	A	3: 64,415,151	N49I	probably damaging	Het
Zfp979	A	T	4: 147,613,131	C374S	probably benign	Het

Other mutations in Fpr-rs6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02836:Fpr-rs6	APN	17	20183045	missense	probably benign	0.30
IGL03380:Fpr-rs6	APN	17	20182983	missense	possibly damaging	0.66
R0149:Fpr-rs6	UTSW	17	20182213	missense	probably benign	0.29
R0190:Fpr-rs6	UTSW	17	20182479	missense	probably benign	0.07
R1347:Fpr-rs6	UTSW	17	20182749	missense	probably benign	0.23
R1347:Fpr-rs6	UTSW	17	20182749	missense	probably benign	0.23
R1934:Fpr-rs6	UTSW	17	20182890	missense	probably benign	0.36
R1965:Fpr-rs6	UTSW	17	20182656	missense	probably damaging	0.98
R3690:Fpr-rs6	UTSW	17	20182875	missense	probably benign	0.02
R4564:Fpr-rs6	UTSW	17	20182906	nonsense	probably null
R4574:Fpr-rs6	UTSW	17	20183097	start codon destroyed	probably damaging	1.00
R5015:Fpr-rs6	UTSW	17	20182346	missense	probably damaging	1.00
R5599:Fpr-rs6	UTSW	17	20182113	missense	probably benign	0.05
R6737:Fpr-rs6	UTSW	17	20183077	missense	probably benign	0.08
R6786:Fpr-rs6	UTSW	17	20182838	missense	possibly damaging	0.95
R6908:Fpr-rs6	UTSW	17	20182439	missense	probably damaging	1.00
R7040:Fpr-rs6	UTSW	17	20182934	missense	probably damaging	1.00
R7462:Fpr-rs6	UTSW	17	20182223	missense	probably damaging	1.00
R7673:Fpr-rs6	UTSW	17	20182737	missense	probably benign	0.03
R7958:Fpr-rs6	UTSW	17	20182443	missense	probably damaging	0.98
R8103:Fpr-rs6	UTSW	17	20182577	missense	possibly damaging	0.69
R8772:Fpr-rs6	UTSW	17	20182233	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCCATCATGAGTGTCACATC -3'
(R):5'- GGCTTCAGCATACCAATGATCTTC -3'

Sequencing Primer
(F):5'- AGTGTCACATCCTATGGCTCAGAG -3'
(R):5'- TATGGACTCATGGCTGCCAAG -3'

Posted On

2015-04-29