Mutagenetix > Incidental Mutation

Incidental Mutation 'R3974:Vmn2r72'

312527

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

EG244114, Vmn2r72-ps

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R3974 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85386992-85404189 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 85399017 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 445 (N445K)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: N445K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: N445K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.9%
20x: 93.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2510039O18Rik	T	C	4: 148,029,488 (GRCm39)	I486T	probably damaging	Het
Abca8a	A	T	11: 109,974,328 (GRCm39)	M202K	probably damaging	Het
Abhd4	T	A	14: 54,500,417 (GRCm39)	I117N	probably damaging	Het
Adam23	T	A	1: 63,586,888 (GRCm39)	Y416*	probably null	Het
Cenpe	A	G	3: 134,940,986 (GRCm39)		probably null	Het
Cenph	A	G	13: 100,900,075 (GRCm39)	V151A	probably damaging	Het
Cfap54	A	G	10: 92,675,333 (GRCm39)	S2863P	possibly damaging	Het
Clca3a1	A	T	3: 144,738,400 (GRCm39)	V36D	probably damaging	Het
Cnbd1	G	A	4: 18,887,693 (GRCm39)	R274C	probably benign	Het
Crot	T	C	5: 9,027,541 (GRCm39)	T264A	probably benign	Het
Dll4	A	G	2: 119,164,573 (GRCm39)	D664G	probably damaging	Het
Ehbp1	C	T	11: 22,087,867 (GRCm39)	A406T	probably benign	Het
Far2	T	A	6: 148,052,252 (GRCm39)	I177N	probably damaging	Het
Flt4	T	G	11: 49,527,567 (GRCm39)	V910G	probably damaging	Het
Fmod	A	G	1: 133,968,496 (GRCm39)	R179G	probably benign	Het
Gdf2	T	A	14: 33,666,791 (GRCm39)	V171D	probably damaging	Het
Gpx6	C	A	13: 21,501,828 (GRCm39)	S150Y	probably damaging	Het
Grik2	A	T	10: 49,298,750 (GRCm39)	Y37N	probably damaging	Het
Grn	T	C	11: 102,327,165 (GRCm39)	V559A	probably damaging	Het
Lrrc37	A	T	11: 103,509,927 (GRCm39)		probably benign	Het
Muc2	T	A	7: 141,300,541 (GRCm39)		probably benign	Het
Myo5b	T	C	18: 74,767,552 (GRCm39)	Y287H	probably damaging	Het
Nbeal2	T	C	9: 110,462,914 (GRCm39)	T1350A	probably damaging	Het
Nfkbiz	T	C	16: 55,638,799 (GRCm39)	I220M	probably benign	Het
Nt5dc2	T	C	14: 30,860,832 (GRCm39)	S439P	probably damaging	Het
Omg	T	A	11: 79,393,224 (GRCm39)	E211D	probably benign	Het
Or52ab7	T	G	7: 102,978,285 (GRCm39)	D197E	probably damaging	Het
Or8k18	A	T	2: 86,085,935 (GRCm39)	I34N	possibly damaging	Het
Pcdhb4	A	G	18: 37,441,901 (GRCm39)	T404A	possibly damaging	Het
Plcl1	T	A	1: 55,737,374 (GRCm39)	M905K	probably benign	Het
Plod2	G	T	9: 92,480,672 (GRCm39)	G422*	probably null	Het
Ppp1r12a	T	C	10: 108,089,341 (GRCm39)	V660A	probably benign	Het
Prdm6	T	C	18: 53,673,278 (GRCm39)	I186T	possibly damaging	Het
Ptprq	T	G	10: 107,547,923 (GRCm39)	K158N	possibly damaging	Het
Rimbp2	A	G	5: 128,874,862 (GRCm39)	V243A	probably damaging	Het
Rp1l1	T	A	14: 64,267,758 (GRCm39)	Y1115N	probably damaging	Het
Rtn4	C	T	11: 29,657,505 (GRCm39)	T553I	probably damaging	Het
Scrn3	T	C	2: 73,166,121 (GRCm39)	S385P	possibly damaging	Het
Serpina1f	C	A	12: 103,659,830 (GRCm39)	G151*	probably null	Het
Sis	T	C	3: 72,850,968 (GRCm39)	T577A	probably damaging	Het
Slco1a1	A	T	6: 141,854,819 (GRCm39)	S611T	probably benign	Het
Smad4	G	T	18: 73,810,807 (GRCm39)	T59K	possibly damaging	Het
Syne1	T	C	10: 4,993,630 (GRCm39)	D8370G	probably benign	Het
Tigd4	G	A	3: 84,502,585 (GRCm39)	A501T	possibly damaging	Het
Tjp1	A	T	7: 64,947,387 (GRCm39)	C1724*	probably null	Het
Tmem107	G	T	11: 68,962,301 (GRCm39)		probably null	Het
Tsc22d1	T	C	14: 76,656,049 (GRCm39)	S761P	probably damaging	Het
Tyw5	A	T	1: 57,430,687 (GRCm39)	D165E	probably damaging	Het
U2af2	T	A	7: 5,072,438 (GRCm39)		probably null	Het
Ube3b	T	A	5: 114,550,491 (GRCm39)	D839E	probably benign	Het
Ush2a	A	G	1: 188,113,698 (GRCm39)	D639G	probably benign	Het
Veph1	A	T	3: 66,065,648 (GRCm39)	M473K	probably benign	Het
Vps37d	T	C	5: 135,105,393 (GRCm39)	M77V	probably null	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,387,542 (GRCm39)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,387,575 (GRCm39)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,399,919 (GRCm39)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,387,170 (GRCm39)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,399,901 (GRCm39)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,387,907 (GRCm39)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,387,391 (GRCm39)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,387,879 (GRCm39)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,401,021 (GRCm39)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,401,249 (GRCm39)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,400,384 (GRCm39)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,404,162 (GRCm39)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,400,075 (GRCm39)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,401,044 (GRCm39)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,404,084 (GRCm39)	missense	probably benign
R0655:Vmn2r72	UTSW	7	85,387,319 (GRCm39)	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85,398,947 (GRCm39)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,400,517 (GRCm39)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,398,396 (GRCm39)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,387,465 (GRCm39)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,398,419 (GRCm39)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,401,000 (GRCm39)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,387,378 (GRCm39)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,398,369 (GRCm39)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,387,444 (GRCm39)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,387,549 (GRCm39)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,400,161 (GRCm39)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,400,477 (GRCm39)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85,398,850 (GRCm39)	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,398,943 (GRCm39)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,400,339 (GRCm39)	missense	probably benign	0.36
R4399:Vmn2r72	UTSW	7	85,387,708 (GRCm39)	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85,387,708 (GRCm39)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,387,036 (GRCm39)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,387,119 (GRCm39)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,387,069 (GRCm39)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,399,806 (GRCm39)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,400,317 (GRCm39)	missense	probably benign
R4991:Vmn2r72	UTSW	7	85,400,338 (GRCm39)	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85,387,693 (GRCm39)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,387,061 (GRCm39)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,387,048 (GRCm39)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,387,462 (GRCm39)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,400,105 (GRCm39)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,401,150 (GRCm39)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,387,058 (GRCm39)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,399,747 (GRCm39)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,400,382 (GRCm39)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,398,892 (GRCm39)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,387,204 (GRCm39)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,399,011 (GRCm39)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,404,125 (GRCm39)	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85,387,482 (GRCm39)	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85,399,771 (GRCm39)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,400,348 (GRCm39)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,400,362 (GRCm39)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,401,146 (GRCm39)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,404,098 (GRCm39)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,399,834 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,398,838 (GRCm39)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,400,441 (GRCm39)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,400,227 (GRCm39)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,401,168 (GRCm39)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,387,383 (GRCm39)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,404,134 (GRCm39)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,398,388 (GRCm39)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,400,411 (GRCm39)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,404,022 (GRCm39)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,404,075 (GRCm39)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,398,399 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CTGATCCACATCTGTAGCCCAC -3'
(R):5'- TGTGGAACTACCTTTACATCCACG -3'

Sequencing Primer
(F):5'- ACATCTGTAGCCCACTCCATC -3'
(R):5'- CATCCACGTGAAATTTATTCTTGC -3'

Posted On

2015-04-30