Mutagenetix > Incidental Mutation

Incidental Mutation 'R3975:Lrba'

312576

Institutional Source

Beutler Lab

Gene Symbol

Lrba

Ensembl Gene

ENSMUSG00000028080

Gene Name

LPS-responsive beige-like anchor

Synonyms

Lba, D3Ertd775e

MMRRC Submission

040939-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R3975 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86224680-86782692 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 86351255 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 1350 (F1350L)

Ref Sequence

ENSEMBL: ENSMUSP00000148618 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107635] [ENSMUST00000192145] [ENSMUST00000194759] [ENSMUST00000212390]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000107635
AA Change: F1350L

PolyPhen 2 Score 0.603 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000103261
Gene: ENSMUSG00000028080
AA Change: F1350L

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	211	377	4.6e-13	PFAM
Pfam:DUF4704	446	717	2.5e-109	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2049	7e-88	PFAM
Pfam:PH_BEACH	2075	2172	9.1e-31	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART
WD40	2760	2798	1.79e-1	SMART
WD40	2801	2840	4.28e0	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000192145
AA Change: F1350L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000142179
Gene: ENSMUSG00000028080
AA Change: F1350L

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	7.4e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.5e-92	PFAM
Pfam:PH_BEACH	2068	2172	7.5e-32	PFAM
Beach	2203	2480	2.87e-207	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000194759
AA Change: F1350L

PolyPhen 2 Score 0.781 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000142043
Gene: ENSMUSG00000028080
AA Change: F1350L

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	8.1e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.6e-92	PFAM
Pfam:PH_BEACH	2068	2172	8.3e-32	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195966

Predicted Effect

probably damaging
Transcript: ENSMUST00000212390
AA Change: F1350L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Meta Mutation Damage Score

0.2786

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 93.6%

Validation Efficiency

95% (59/62)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased numbers of myeloid-derived suppressor cells and regulatory T cells, abnormal NK cell physiology, impaired rejection of allogeneic, xenogeneic and missing self bone-marrow grafts, and resistance to acute graft vs host disease. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam23	T	A	1: 63,547,729 (GRCm38)	Y416*	probably null	Het
Akr1b10	G	T	6: 34,392,496 (GRCm38)		probably null	Het
Arap2	G	T	5: 62,748,894 (GRCm38)	P261T	possibly damaging	Het
Bckdha	C	A	7: 25,631,433 (GRCm38)	D53Y	probably damaging	Het
Bfsp2	A	G	9: 103,480,072 (GRCm38)	V52A	probably benign	Het
Bola3	T	C	6: 83,351,267 (GRCm38)	L45P	probably benign	Het
Cacna2d4	A	G	6: 119,278,173 (GRCm38)		probably null	Het
Ceacam16	C	A	7: 19,853,612 (GRCm38)	Q410H	probably damaging	Het
Cenpe	A	G	3: 135,235,225 (GRCm38)		probably null	Het
Cenpe	T	C	3: 135,238,472 (GRCm38)		probably null	Het
Clca1	A	T	3: 145,032,639 (GRCm38)	V36D	probably damaging	Het
Copa	T	A	1: 172,121,245 (GRCm38)	S1155T	probably benign	Het
Crb2	C	A	2: 37,793,668 (GRCm38)	P1061T	possibly damaging	Het
Crot	T	C	5: 8,977,541 (GRCm38)	T264A	probably benign	Het
Cyp51	C	T	5: 4,091,877 (GRCm38)	G346S	probably damaging	Het
Dnah6	A	G	6: 73,121,992 (GRCm38)	S2027P	possibly damaging	Het
Fam129a	T	C	1: 151,649,335 (GRCm38)	Y164H	probably damaging	Het
Fbxo18	T	C	2: 11,767,210 (GRCm38)	H220R	possibly damaging	Het
Gdf2	T	A	14: 33,944,834 (GRCm38)	V171D	probably damaging	Het
Gm9825	A	T	6: 7,983,149 (GRCm38)		noncoding transcript	Het
Golgb1	T	G	16: 36,918,571 (GRCm38)	V2424G	probably damaging	Het
Gpbp1l1	T	C	4: 116,570,985 (GRCm38)		probably null	Het
Gpx6	C	A	13: 21,317,658 (GRCm38)	S150Y	probably damaging	Het
Greb1l	A	G	18: 10,522,247 (GRCm38)	N672S	possibly damaging	Het
Kcnma1	C	T	14: 24,003,747 (GRCm38)		probably null	Het
Nat8f4	A	G	6: 85,901,070 (GRCm38)	V157A	possibly damaging	Het
Nt5dc2	T	C	14: 31,138,875 (GRCm38)	S439P	probably damaging	Het
Olfr1090	T	A	2: 86,754,543 (GRCm38)	H65L	probably damaging	Het
Olfr134	A	G	17: 38,175,495 (GRCm38)	N137S	probably benign	Het
Olfr141	G	A	2: 86,806,460 (GRCm38)	P180S	possibly damaging	Het
Olfr693	T	C	7: 106,677,785 (GRCm38)	R234G	probably damaging	Het
Orm3	A	T	4: 63,356,158 (GRCm38)		probably null	Het
Otof	A	G	5: 30,370,712 (GRCm38)	L1929P	probably damaging	Het
Pex5l	C	A	3: 33,015,015 (GRCm38)	C111F	probably damaging	Het
Plcl1	T	A	1: 55,698,215 (GRCm38)	M905K	probably benign	Het
Prdm6	T	C	18: 53,540,206 (GRCm38)	I186T	possibly damaging	Het
Rara	T	G	11: 98,970,569 (GRCm38)	I236S	probably damaging	Het
Reln	A	T	5: 21,995,366 (GRCm38)	S1379T	possibly damaging	Het
Rp1l1	T	A	14: 64,030,309 (GRCm38)	Y1115N	probably damaging	Het
Rpe65	A	T	3: 159,604,585 (GRCm38)	N135I	probably damaging	Het
Rps6	A	G	4: 86,856,813 (GRCm38)	V18A	probably benign	Het
Scrn3	T	C	2: 73,335,777 (GRCm38)	S385P	possibly damaging	Het
Sis	T	C	3: 72,943,635 (GRCm38)	T577A	probably damaging	Het
Slx1b	G	A	7: 126,691,807 (GRCm38)	L239F	probably damaging	Het
Smad4	G	T	18: 73,677,736 (GRCm38)	T59K	possibly damaging	Het
Smad6	A	G	9: 64,020,930 (GRCm38)	V32A	probably benign	Het
Smc6	T	A	12: 11,274,074 (GRCm38)	F73L	probably damaging	Het
Sorbs2	T	C	8: 45,772,710 (GRCm38)		probably null	Het
Svbp	T	A	4: 119,195,893 (GRCm38)	F32I	probably benign	Het
Tap1	C	A	17: 34,189,567 (GRCm38)		probably benign	Het
Tesk1	C	T	4: 43,445,786 (GRCm38)	P280S	possibly damaging	Het
Thrb	A	G	14: 18,033,456 (GRCm38)	I406M	probably damaging	Het
Tsc22d1	T	C	14: 76,418,609 (GRCm38)	S761P	probably damaging	Het
Ttn	T	C	2: 76,876,653 (GRCm38)		probably benign	Het
Umodl1	C	A	17: 30,984,789 (GRCm38)	Y525*	probably null	Het
Vmn2r70	C	T	7: 85,559,332 (GRCm38)	V646I	probably benign	Het
Wipf1	C	T	2: 73,437,169 (GRCm38)	G295D	probably benign	Het
Wisp3	C	G	10: 39,155,098 (GRCm38)	C143S	probably damaging	Het
Zim1	A	T	7: 6,677,130 (GRCm38)	H511Q	probably damaging	Het

Other mutations in Lrba

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Lrba	APN	3	86,359,782 (GRCm38)	missense	probably benign	0.00
IGL00788:Lrba	APN	3	86,327,685 (GRCm38)	missense	probably damaging	0.97
IGL01139:Lrba	APN	3	86,642,662 (GRCm38)	missense	possibly damaging	0.88
IGL01302:Lrba	APN	3	86,295,400 (GRCm38)	missense	probably damaging	1.00
IGL01612:Lrba	APN	3	86,776,177 (GRCm38)	missense	possibly damaging	0.89
IGL01718:Lrba	APN	3	86,351,248 (GRCm38)	missense	probably damaging	1.00
IGL01719:Lrba	APN	3	86,327,596 (GRCm38)	splice site	probably benign
IGL01730:Lrba	APN	3	86,741,424 (GRCm38)	missense	possibly damaging	0.89
IGL01735:Lrba	APN	3	86,327,661 (GRCm38)	missense	probably benign	0.28
IGL01875:Lrba	APN	3	86,310,047 (GRCm38)	missense	probably damaging	1.00
IGL01884:Lrba	APN	3	86,310,412 (GRCm38)	missense	possibly damaging	0.86
IGL02264:Lrba	APN	3	86,780,262 (GRCm38)	missense	probably damaging	0.99
IGL02638:Lrba	APN	3	86,325,073 (GRCm38)	missense	probably damaging	0.97
IGL02647:Lrba	APN	3	86,359,731 (GRCm38)	missense	probably benign	0.00
IGL02664:Lrba	APN	3	86,325,731 (GRCm38)	missense	possibly damaging	0.84
IGL02728:Lrba	APN	3	86,776,049 (GRCm38)	missense	probably damaging	0.99
IGL02730:Lrba	APN	3	86,328,199 (GRCm38)	missense	probably damaging	1.00
IGL02883:Lrba	APN	3	86,445,413 (GRCm38)	missense	probably damaging	0.99
IGL02883:Lrba	APN	3	86,354,206 (GRCm38)	missense	probably damaging	1.00
IGL02948:Lrba	APN	3	86,310,384 (GRCm38)	splice site	probably null
IGL03090:Lrba	APN	3	86,773,141 (GRCm38)	missense	probably benign	0.01
molasses	UTSW	3	86,354,307 (GRCm38)	critical splice donor site	probably null
oscar	UTSW	3	86,350,304 (GRCm38)	nonsense	probably null
oscar2	UTSW	3	86,664,458 (GRCm38)	nonsense	probably null
P0023:Lrba	UTSW	3	86,417,935 (GRCm38)	missense	probably damaging	1.00
PIT4802001:Lrba	UTSW	3	86,664,494 (GRCm38)	nonsense	probably null
R0077:Lrba	UTSW	3	86,542,688 (GRCm38)	missense	probably damaging	0.99
R0189:Lrba	UTSW	3	86,368,509 (GRCm38)	missense	probably damaging	1.00
R0217:Lrba	UTSW	3	86,642,722 (GRCm38)	missense	probably damaging	1.00
R0349:Lrba	UTSW	3	86,540,005 (GRCm38)	missense	probably damaging	1.00
R0396:Lrba	UTSW	3	86,295,179 (GRCm38)	missense	probably damaging	1.00
R0417:Lrba	UTSW	3	86,715,654 (GRCm38)	missense	probably damaging	1.00
R0536:Lrba	UTSW	3	86,715,532 (GRCm38)	missense	probably damaging	1.00
R0712:Lrba	UTSW	3	86,297,990 (GRCm38)	nonsense	probably null
R0722:Lrba	UTSW	3	86,605,989 (GRCm38)	critical splice donor site	probably null
R0828:Lrba	UTSW	3	86,608,370 (GRCm38)	splice site	probably null
R0927:Lrba	UTSW	3	86,780,233 (GRCm38)	missense	probably damaging	1.00
R1120:Lrba	UTSW	3	86,295,192 (GRCm38)	missense	probably damaging	1.00
R1141:Lrba	UTSW	3	86,619,558 (GRCm38)	missense	probably damaging	1.00
R1276:Lrba	UTSW	3	86,664,526 (GRCm38)	missense	probably damaging	1.00
R1449:Lrba	UTSW	3	86,354,278 (GRCm38)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,737,142 (GRCm38)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,737,142 (GRCm38)	missense	probably damaging	1.00
R1474:Lrba	UTSW	3	86,780,266 (GRCm38)	splice site	probably benign
R1558:Lrba	UTSW	3	86,351,315 (GRCm38)	missense	probably damaging	1.00
R1596:Lrba	UTSW	3	86,350,304 (GRCm38)	nonsense	probably null
R1652:Lrba	UTSW	3	86,539,938 (GRCm38)	missense	probably damaging	1.00
R1800:Lrba	UTSW	3	86,351,868 (GRCm38)	missense	probably benign	0.00
R1819:Lrba	UTSW	3	86,542,634 (GRCm38)	missense	possibly damaging	0.80
R1862:Lrba	UTSW	3	86,773,203 (GRCm38)	critical splice donor site	probably null
R1917:Lrba	UTSW	3	86,664,501 (GRCm38)	missense	probably damaging	1.00
R1965:Lrba	UTSW	3	86,605,868 (GRCm38)	critical splice acceptor site	probably null
R1966:Lrba	UTSW	3	86,605,868 (GRCm38)	critical splice acceptor site	probably null
R1969:Lrba	UTSW	3	86,608,389 (GRCm38)	missense	probably damaging	0.99
R2011:Lrba	UTSW	3	86,310,017 (GRCm38)	missense	probably damaging	0.99
R2179:Lrba	UTSW	3	86,354,281 (GRCm38)	missense	probably damaging	1.00
R2186:Lrba	UTSW	3	86,304,336 (GRCm38)	missense	probably damaging	1.00
R2281:Lrba	UTSW	3	86,776,103 (GRCm38)	missense	possibly damaging	0.46
R2359:Lrba	UTSW	3	86,348,750 (GRCm38)	missense	probably benign	0.01
R2412:Lrba	UTSW	3	86,327,700 (GRCm38)	missense	probably damaging	1.00
R2496:Lrba	UTSW	3	86,532,087 (GRCm38)	missense	probably damaging	1.00
R3153:Lrba	UTSW	3	86,285,219 (GRCm38)	missense	probably damaging	0.99
R3708:Lrba	UTSW	3	86,285,024 (GRCm38)	missense	possibly damaging	0.80
R3746:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3747:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3748:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3749:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3750:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3758:Lrba	UTSW	3	86,776,049 (GRCm38)	missense	probably damaging	0.99
R4210:Lrba	UTSW	3	86,360,126 (GRCm38)	missense	probably damaging	1.00
R4258:Lrba	UTSW	3	86,445,349 (GRCm38)	missense	probably damaging	1.00
R4657:Lrba	UTSW	3	86,737,164 (GRCm38)	missense	probably damaging	1.00
R4713:Lrba	UTSW	3	86,359,868 (GRCm38)	missense	probably benign	0.13
R4716:Lrba	UTSW	3	86,642,714 (GRCm38)	missense	probably damaging	0.99
R4811:Lrba	UTSW	3	86,776,141 (GRCm38)	missense	probably damaging	1.00
R4827:Lrba	UTSW	3	86,360,150 (GRCm38)	missense	possibly damaging	0.85
R4840:Lrba	UTSW	3	86,619,509 (GRCm38)	critical splice acceptor site	probably null
R4920:Lrba	UTSW	3	86,664,458 (GRCm38)	nonsense	probably null
R4948:Lrba	UTSW	3	86,285,028 (GRCm38)	missense	probably damaging	1.00
R4970:Lrba	UTSW	3	86,225,371 (GRCm38)	missense	probably benign	0.23
R4985:Lrba	UTSW	3	86,327,436 (GRCm38)	splice site	probably null
R4993:Lrba	UTSW	3	86,360,037 (GRCm38)	missense	probably damaging	1.00
R5107:Lrba	UTSW	3	86,359,779 (GRCm38)	missense	possibly damaging	0.47
R5112:Lrba	UTSW	3	86,225,371 (GRCm38)	missense	probably benign	0.23
R5122:Lrba	UTSW	3	86,349,154 (GRCm38)	nonsense	probably null
R5155:Lrba	UTSW	3	86,351,300 (GRCm38)	missense	probably benign	0.25
R5194:Lrba	UTSW	3	86,328,219 (GRCm38)	missense	probably damaging	1.00
R5280:Lrba	UTSW	3	86,325,022 (GRCm38)	missense	possibly damaging	0.94
R5445:Lrba	UTSW	3	86,368,595 (GRCm38)	missense	probably benign
R5469:Lrba	UTSW	3	86,542,641 (GRCm38)	missense	probably damaging	1.00
R5513:Lrba	UTSW	3	86,542,641 (GRCm38)	missense	probably damaging	1.00
R5578:Lrba	UTSW	3	86,757,507 (GRCm38)	missense	probably benign	0.27
R5740:Lrba	UTSW	3	86,328,342 (GRCm38)	missense	probably damaging	1.00
R5868:Lrba	UTSW	3	86,319,604 (GRCm38)	missense	probably damaging	1.00
R6104:Lrba	UTSW	3	86,353,792 (GRCm38)	missense	probably damaging	1.00
R6166:Lrba	UTSW	3	86,354,307 (GRCm38)	critical splice donor site	probably null
R6279:Lrba	UTSW	3	86,348,864 (GRCm38)	missense	probably benign	0.26
R6330:Lrba	UTSW	3	86,348,357 (GRCm38)	missense	probably benign	0.07
R6367:Lrba	UTSW	3	86,368,562 (GRCm38)	missense	probably benign	0.42
R6571:Lrba	UTSW	3	86,360,060 (GRCm38)	missense	probably damaging	1.00
R6584:Lrba	UTSW	3	86,664,576 (GRCm38)	missense	probably damaging	1.00
R6698:Lrba	UTSW	3	86,304,425 (GRCm38)	missense	probably damaging	0.99
R6763:Lrba	UTSW	3	86,354,263 (GRCm38)	missense	probably damaging	1.00
R6834:Lrba	UTSW	3	86,350,286 (GRCm38)	missense	probably benign	0.00
R6951:Lrba	UTSW	3	86,745,873 (GRCm38)	missense	probably benign	0.01
R6969:Lrba	UTSW	3	86,619,590 (GRCm38)	missense	probably benign	0.21
R7045:Lrba	UTSW	3	86,285,091 (GRCm38)	missense	probably benign	0.03
R7133:Lrba	UTSW	3	86,394,931 (GRCm38)	splice site	probably null
R7182:Lrba	UTSW	3	86,741,458 (GRCm38)	frame shift	probably null
R7214:Lrba	UTSW	3	86,328,326 (GRCm38)	missense	probably damaging	1.00
R7224:Lrba	UTSW	3	86,395,246 (GRCm38)	missense	probably damaging	1.00
R7243:Lrba	UTSW	3	86,751,516 (GRCm38)	splice site	probably null
R7350:Lrba	UTSW	3	86,351,902 (GRCm38)	missense	probably damaging	0.96
R7380:Lrba	UTSW	3	86,325,074 (GRCm38)	missense	probably damaging	1.00
R7492:Lrba	UTSW	3	86,664,528 (GRCm38)	missense	probably damaging	1.00
R7651:Lrba	UTSW	3	86,741,466 (GRCm38)	nonsense	probably null
R7729:Lrba	UTSW	3	86,318,167 (GRCm38)	missense	probably damaging	1.00
R7754:Lrba	UTSW	3	86,445,397 (GRCm38)	missense	probably damaging	1.00
R7762:Lrba	UTSW	3	86,532,201 (GRCm38)	missense	probably damaging	0.99
R7855:Lrba	UTSW	3	86,315,430 (GRCm38)	missense	possibly damaging	0.94
R7867:Lrba	UTSW	3	86,368,589 (GRCm38)	missense	probably damaging	1.00
R7912:Lrba	UTSW	3	86,715,565 (GRCm38)	missense	probably damaging	1.00
R7995:Lrba	UTSW	3	86,619,551 (GRCm38)	missense	probably damaging	1.00
R8013:Lrba	UTSW	3	86,417,971 (GRCm38)	missense	probably damaging	1.00
R8014:Lrba	UTSW	3	86,417,971 (GRCm38)	missense	probably damaging	1.00
R8024:Lrba	UTSW	3	86,295,401 (GRCm38)	nonsense	probably null
R8027:Lrba	UTSW	3	86,417,912 (GRCm38)	missense	probably benign	0.05
R8090:Lrba	UTSW	3	86,348,489 (GRCm38)	missense	probably benign
R8111:Lrba	UTSW	3	86,327,705 (GRCm38)	missense	probably damaging	1.00
R8118:Lrba	UTSW	3	86,354,226 (GRCm38)	missense	probably benign
R8204:Lrba	UTSW	3	86,315,403 (GRCm38)	missense	possibly damaging	0.95
R8239:Lrba	UTSW	3	86,542,575 (GRCm38)	missense	probably damaging	1.00
R8509:Lrba	UTSW	3	86,348,176 (GRCm38)	missense	probably benign	0.04
R8532:Lrba	UTSW	3	86,757,483 (GRCm38)	missense	probably damaging	1.00
R8726:Lrba	UTSW	3	86,353,755 (GRCm38)	missense	probably benign
R8744:Lrba	UTSW	3	86,304,333 (GRCm38)	missense	probably benign	0.08
R8782:Lrba	UTSW	3	86,642,669 (GRCm38)	missense	probably benign	0.00
R8784:Lrba	UTSW	3	86,375,928 (GRCm38)	missense	probably damaging	1.00
R8922:Lrba	UTSW	3	86,356,666 (GRCm38)	missense	probably damaging	1.00
R8964:Lrba	UTSW	3	86,351,245 (GRCm38)	missense	probably benign	0.22
R8971:Lrba	UTSW	3	86,615,081 (GRCm38)	missense	probably benign	0.00
R9046:Lrba	UTSW	3	86,395,236 (GRCm38)	missense	possibly damaging	0.94
R9155:Lrba	UTSW	3	86,295,201 (GRCm38)	missense	probably damaging	1.00
R9236:Lrba	UTSW	3	86,353,759 (GRCm38)	missense	probably benign	0.05
R9266:Lrba	UTSW	3	86,291,467 (GRCm38)	missense	probably benign	0.08
R9297:Lrba	UTSW	3	86,373,566 (GRCm38)	missense	probably damaging	1.00
R9404:Lrba	UTSW	3	86,297,917 (GRCm38)	missense	probably damaging	0.99
R9617:Lrba	UTSW	3	86,359,862 (GRCm38)	missense	probably benign
R9640:Lrba	UTSW	3	86,619,568 (GRCm38)	nonsense	probably null
R9779:Lrba	UTSW	3	86,325,771 (GRCm38)	missense	probably damaging	1.00
X0065:Lrba	UTSW	3	86,325,089 (GRCm38)	missense	possibly damaging	0.95
X0065:Lrba	UTSW	3	86,297,899 (GRCm38)	missense	probably damaging	1.00
Z1176:Lrba	UTSW	3	86,751,532 (GRCm38)	missense	possibly damaging	0.85
Z1176:Lrba	UTSW	3	86,715,538 (GRCm38)	missense	probably benign	0.31
Z1177:Lrba	UTSW	3	86,540,049 (GRCm38)	missense	probably null	1.00

Predicted Primers

PCR Primer
(F):5'- GCTTGTGCATAGACAGTGACTTC -3'
(R):5'- TGTATAGAACCCACTGTACAACG -3'

Sequencing Primer
(F):5'- TGTGCATAGACAGTGACTTCTGACAG -3'
(R):5'- CGCTGTAATCATTGAGGACAC -3'

Posted On

2015-04-30