Incidental Mutation 'R3975:Arap2'
ID 312592
Institutional Source Beutler Lab
Gene Symbol Arap2
Ensembl Gene ENSMUSG00000037999
Gene Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms Centd1
MMRRC Submission 040939-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3975 (G1)
Quality Score 222
Status Validated
Chromosome 5
Chromosomal Location 62602445-62766159 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 62748894 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 261 (P261T)
Ref Sequence ENSEMBL: ENSMUSP00000075924 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076623] [ENSMUST00000159470]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000076623
AA Change: P261T

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000075924
Gene: ENSMUSG00000037999
AA Change: P261T

DomainStartEndE-ValueType
SAM 3 70 3.69e-7 SMART
low complexity region 222 233 N/A INTRINSIC
PH 481 574 6.45e-17 SMART
PH 586 679 9.05e-12 SMART
ArfGap 684 805 9.2e-33 SMART
PH 891 1003 1.51e-8 SMART
PH 1013 1112 9.21e-4 SMART
RhoGAP 1124 1300 1.36e-50 SMART
Pfam:RA 1325 1416 2.1e-7 PFAM
PH 1429 1533 2.68e-14 SMART
coiled coil region 1561 1590 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159470
SMART Domains Protein: ENSMUSP00000124743
Gene: ENSMUSG00000037999

DomainStartEndE-ValueType
SAM 3 70 3.69e-7 SMART
Meta Mutation Damage Score 0.1587 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.6%
Validation Efficiency 95% (59/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam23 T A 1: 63,547,729 (GRCm38) Y416* probably null Het
Akr1b10 G T 6: 34,392,496 (GRCm38) probably null Het
Bckdha C A 7: 25,631,433 (GRCm38) D53Y probably damaging Het
Bfsp2 A G 9: 103,480,072 (GRCm38) V52A probably benign Het
Bola3 T C 6: 83,351,267 (GRCm38) L45P probably benign Het
Cacna2d4 A G 6: 119,278,173 (GRCm38) probably null Het
Ceacam16 C A 7: 19,853,612 (GRCm38) Q410H probably damaging Het
Cenpe A G 3: 135,235,225 (GRCm38) probably null Het
Cenpe T C 3: 135,238,472 (GRCm38) probably null Het
Clca1 A T 3: 145,032,639 (GRCm38) V36D probably damaging Het
Copa T A 1: 172,121,245 (GRCm38) S1155T probably benign Het
Crb2 C A 2: 37,793,668 (GRCm38) P1061T possibly damaging Het
Crot T C 5: 8,977,541 (GRCm38) T264A probably benign Het
Cyp51 C T 5: 4,091,877 (GRCm38) G346S probably damaging Het
Dnah6 A G 6: 73,121,992 (GRCm38) S2027P possibly damaging Het
Fam129a T C 1: 151,649,335 (GRCm38) Y164H probably damaging Het
Fbxo18 T C 2: 11,767,210 (GRCm38) H220R possibly damaging Het
Gdf2 T A 14: 33,944,834 (GRCm38) V171D probably damaging Het
Gm9825 A T 6: 7,983,149 (GRCm38) noncoding transcript Het
Golgb1 T G 16: 36,918,571 (GRCm38) V2424G probably damaging Het
Gpbp1l1 T C 4: 116,570,985 (GRCm38) probably null Het
Gpx6 C A 13: 21,317,658 (GRCm38) S150Y probably damaging Het
Greb1l A G 18: 10,522,247 (GRCm38) N672S possibly damaging Het
Kcnma1 C T 14: 24,003,747 (GRCm38) probably null Het
Lrba T C 3: 86,351,255 (GRCm38) F1350L probably damaging Het
Nat8f4 A G 6: 85,901,070 (GRCm38) V157A possibly damaging Het
Nt5dc2 T C 14: 31,138,875 (GRCm38) S439P probably damaging Het
Olfr1090 T A 2: 86,754,543 (GRCm38) H65L probably damaging Het
Olfr134 A G 17: 38,175,495 (GRCm38) N137S probably benign Het
Olfr141 G A 2: 86,806,460 (GRCm38) P180S possibly damaging Het
Olfr693 T C 7: 106,677,785 (GRCm38) R234G probably damaging Het
Orm3 A T 4: 63,356,158 (GRCm38) probably null Het
Otof A G 5: 30,370,712 (GRCm38) L1929P probably damaging Het
Pex5l C A 3: 33,015,015 (GRCm38) C111F probably damaging Het
Plcl1 T A 1: 55,698,215 (GRCm38) M905K probably benign Het
Prdm6 T C 18: 53,540,206 (GRCm38) I186T possibly damaging Het
Rara T G 11: 98,970,569 (GRCm38) I236S probably damaging Het
Reln A T 5: 21,995,366 (GRCm38) S1379T possibly damaging Het
Rp1l1 T A 14: 64,030,309 (GRCm38) Y1115N probably damaging Het
Rpe65 A T 3: 159,604,585 (GRCm38) N135I probably damaging Het
Rps6 A G 4: 86,856,813 (GRCm38) V18A probably benign Het
Scrn3 T C 2: 73,335,777 (GRCm38) S385P possibly damaging Het
Sis T C 3: 72,943,635 (GRCm38) T577A probably damaging Het
Slx1b G A 7: 126,691,807 (GRCm38) L239F probably damaging Het
Smad4 G T 18: 73,677,736 (GRCm38) T59K possibly damaging Het
Smad6 A G 9: 64,020,930 (GRCm38) V32A probably benign Het
Smc6 T A 12: 11,274,074 (GRCm38) F73L probably damaging Het
Sorbs2 T C 8: 45,772,710 (GRCm38) probably null Het
Svbp T A 4: 119,195,893 (GRCm38) F32I probably benign Het
Tap1 C A 17: 34,189,567 (GRCm38) probably benign Het
Tesk1 C T 4: 43,445,786 (GRCm38) P280S possibly damaging Het
Thrb A G 14: 18,033,456 (GRCm38) I406M probably damaging Het
Tsc22d1 T C 14: 76,418,609 (GRCm38) S761P probably damaging Het
Ttn T C 2: 76,876,653 (GRCm38) probably benign Het
Umodl1 C A 17: 30,984,789 (GRCm38) Y525* probably null Het
Vmn2r70 C T 7: 85,559,332 (GRCm38) V646I probably benign Het
Wipf1 C T 2: 73,437,169 (GRCm38) G295D probably benign Het
Wisp3 C G 10: 39,155,098 (GRCm38) C143S probably damaging Het
Zim1 A T 7: 6,677,130 (GRCm38) H511Q probably damaging Het
Other mutations in Arap2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Arap2 APN 5 62,635,962 (GRCm38) missense probably damaging 1.00
IGL00642:Arap2 APN 5 62,733,058 (GRCm38) nonsense probably null
IGL00705:Arap2 APN 5 62,678,023 (GRCm38) missense probably damaging 1.00
IGL00942:Arap2 APN 5 62,698,389 (GRCm38) nonsense probably null
IGL01069:Arap2 APN 5 62,649,856 (GRCm38) missense probably benign
IGL01601:Arap2 APN 5 62,641,342 (GRCm38) missense probably damaging 1.00
IGL01986:Arap2 APN 5 62,621,922 (GRCm38) missense probably damaging 1.00
IGL02032:Arap2 APN 5 62,670,997 (GRCm38) missense probably damaging 0.99
IGL02262:Arap2 APN 5 62,642,841 (GRCm38) missense probably damaging 1.00
IGL02331:Arap2 APN 5 62,649,682 (GRCm38) splice site probably benign
IGL02527:Arap2 APN 5 62,749,307 (GRCm38) missense probably benign
IGL02803:Arap2 APN 5 62,749,109 (GRCm38) missense probably benign
IGL02864:Arap2 APN 5 62,677,965 (GRCm38) missense probably damaging 1.00
IGL03078:Arap2 APN 5 62,733,065 (GRCm38) splice site probably benign
IGL03154:Arap2 APN 5 62,642,925 (GRCm38) missense probably damaging 1.00
IGL03213:Arap2 APN 5 62,749,095 (GRCm38) missense probably benign 0.00
IGL03279:Arap2 APN 5 62,621,910 (GRCm38) missense probably damaging 1.00
IGL03288:Arap2 APN 5 62,604,616 (GRCm38) missense probably benign 0.00
PIT4354001:Arap2 UTSW 5 62,654,049 (GRCm38) missense probably damaging 1.00
R0012:Arap2 UTSW 5 62,683,484 (GRCm38) missense probably damaging 1.00
R0013:Arap2 UTSW 5 62,683,484 (GRCm38) missense probably damaging 1.00
R0013:Arap2 UTSW 5 62,683,484 (GRCm38) missense probably damaging 1.00
R0166:Arap2 UTSW 5 62,676,018 (GRCm38) missense probably damaging 1.00
R0472:Arap2 UTSW 5 62,706,659 (GRCm38) missense probably damaging 1.00
R0506:Arap2 UTSW 5 62,606,131 (GRCm38) missense possibly damaging 0.87
R0551:Arap2 UTSW 5 62,641,323 (GRCm38) splice site probably null
R0607:Arap2 UTSW 5 62,606,131 (GRCm38) missense possibly damaging 0.87
R0617:Arap2 UTSW 5 62,649,907 (GRCm38) splice site probably benign
R0975:Arap2 UTSW 5 62,730,886 (GRCm38) splice site probably benign
R0976:Arap2 UTSW 5 62,649,884 (GRCm38) missense probably damaging 1.00
R1164:Arap2 UTSW 5 62,683,477 (GRCm38) missense probably damaging 1.00
R1268:Arap2 UTSW 5 62,730,621 (GRCm38) missense probably benign 0.00
R1480:Arap2 UTSW 5 62,669,129 (GRCm38) nonsense probably null
R1502:Arap2 UTSW 5 62,604,404 (GRCm38) missense probably benign 0.00
R1543:Arap2 UTSW 5 62,606,155 (GRCm38) nonsense probably null
R1865:Arap2 UTSW 5 62,698,263 (GRCm38) missense probably damaging 0.97
R1962:Arap2 UTSW 5 62,676,664 (GRCm38) missense possibly damaging 0.82
R2040:Arap2 UTSW 5 62,748,916 (GRCm38) missense probably damaging 0.99
R2118:Arap2 UTSW 5 62,706,685 (GRCm38) missense probably damaging 1.00
R2131:Arap2 UTSW 5 62,677,958 (GRCm38) missense probably damaging 1.00
R2201:Arap2 UTSW 5 62,706,685 (GRCm38) missense probably damaging 1.00
R2215:Arap2 UTSW 5 62,677,176 (GRCm38) missense probably damaging 1.00
R3027:Arap2 UTSW 5 62,669,897 (GRCm38) missense probably damaging 1.00
R3053:Arap2 UTSW 5 62,748,857 (GRCm38) missense probably benign 0.35
R4272:Arap2 UTSW 5 62,670,979 (GRCm38) missense possibly damaging 0.63
R4273:Arap2 UTSW 5 62,670,979 (GRCm38) missense possibly damaging 0.63
R4326:Arap2 UTSW 5 62,621,863 (GRCm38) missense possibly damaging 0.50
R4327:Arap2 UTSW 5 62,621,863 (GRCm38) missense possibly damaging 0.50
R4328:Arap2 UTSW 5 62,621,863 (GRCm38) missense possibly damaging 0.50
R4451:Arap2 UTSW 5 62,749,170 (GRCm38) missense probably benign 0.06
R4659:Arap2 UTSW 5 62,654,126 (GRCm38) missense possibly damaging 0.94
R4665:Arap2 UTSW 5 62,669,969 (GRCm38) missense possibly damaging 0.95
R4715:Arap2 UTSW 5 62,749,094 (GRCm38) missense probably benign 0.43
R4808:Arap2 UTSW 5 62,730,641 (GRCm38) missense probably benign 0.23
R4941:Arap2 UTSW 5 62,749,478 (GRCm38) missense probably benign 0.20
R4983:Arap2 UTSW 5 62,676,525 (GRCm38) missense probably damaging 0.98
R5095:Arap2 UTSW 5 62,654,049 (GRCm38) missense probably damaging 1.00
R5156:Arap2 UTSW 5 62,669,181 (GRCm38) nonsense probably null
R5201:Arap2 UTSW 5 62,683,489 (GRCm38) missense probably damaging 1.00
R5346:Arap2 UTSW 5 62,714,746 (GRCm38) missense probably benign 0.39
R5359:Arap2 UTSW 5 62,683,419 (GRCm38) nonsense probably null
R5426:Arap2 UTSW 5 62,642,816 (GRCm38) missense probably benign 0.02
R5503:Arap2 UTSW 5 62,630,186 (GRCm38) missense probably damaging 1.00
R5605:Arap2 UTSW 5 62,615,067 (GRCm38) missense possibly damaging 0.47
R5764:Arap2 UTSW 5 62,642,854 (GRCm38) missense probably damaging 1.00
R5813:Arap2 UTSW 5 62,677,163 (GRCm38) missense probably damaging 1.00
R5846:Arap2 UTSW 5 62,649,773 (GRCm38) missense probably damaging 1.00
R6084:Arap2 UTSW 5 62,670,954 (GRCm38) missense possibly damaging 0.89
R6173:Arap2 UTSW 5 62,749,622 (GRCm38) missense probably damaging 1.00
R6175:Arap2 UTSW 5 62,714,731 (GRCm38) critical splice donor site probably null
R6249:Arap2 UTSW 5 62,646,193 (GRCm38) missense probably damaging 0.99
R6386:Arap2 UTSW 5 62,604,522 (GRCm38) missense possibly damaging 0.89
R6424:Arap2 UTSW 5 62,683,364 (GRCm38) missense probably damaging 1.00
R6744:Arap2 UTSW 5 62,748,938 (GRCm38) missense probably damaging 1.00
R6766:Arap2 UTSW 5 62,677,100 (GRCm38) critical splice donor site probably null
R6990:Arap2 UTSW 5 62,676,517 (GRCm38) missense probably damaging 0.96
R7067:Arap2 UTSW 5 62,654,044 (GRCm38) critical splice donor site probably null
R7098:Arap2 UTSW 5 62,675,950 (GRCm38) critical splice donor site probably null
R7107:Arap2 UTSW 5 62,606,208 (GRCm38) missense probably damaging 0.98
R7156:Arap2 UTSW 5 62,604,571 (GRCm38) missense probably damaging 1.00
R7174:Arap2 UTSW 5 62,604,278 (GRCm38) missense probably benign
R7187:Arap2 UTSW 5 62,669,053 (GRCm38) missense probably damaging 0.99
R7197:Arap2 UTSW 5 62,641,386 (GRCm38) missense possibly damaging 0.89
R7214:Arap2 UTSW 5 62,749,338 (GRCm38) missense probably benign 0.00
R7317:Arap2 UTSW 5 62,649,724 (GRCm38) missense probably damaging 1.00
R7392:Arap2 UTSW 5 62,698,385 (GRCm38) missense possibly damaging 0.54
R7438:Arap2 UTSW 5 62,749,475 (GRCm38) missense probably damaging 0.99
R7452:Arap2 UTSW 5 62,676,549 (GRCm38) missense probably benign 0.00
R7495:Arap2 UTSW 5 62,676,550 (GRCm38) missense possibly damaging 0.78
R7796:Arap2 UTSW 5 62,730,762 (GRCm38) missense probably damaging 1.00
R7936:Arap2 UTSW 5 62,730,705 (GRCm38) missense probably damaging 0.96
R8116:Arap2 UTSW 5 62,730,611 (GRCm38) missense probably benign 0.00
R8172:Arap2 UTSW 5 62,621,981 (GRCm38) splice site probably null
R8277:Arap2 UTSW 5 62,613,992 (GRCm38) critical splice donor site probably null
R8369:Arap2 UTSW 5 62,604,326 (GRCm38) nonsense probably null
R8398:Arap2 UTSW 5 62,748,909 (GRCm38) missense probably damaging 1.00
R8893:Arap2 UTSW 5 62,730,694 (GRCm38) missense probably damaging 1.00
R8973:Arap2 UTSW 5 62,698,325 (GRCm38) nonsense probably null
R9102:Arap2 UTSW 5 62,748,998 (GRCm38) missense probably benign 0.03
R9121:Arap2 UTSW 5 62,748,983 (GRCm38) missense possibly damaging 0.84
R9174:Arap2 UTSW 5 62,698,263 (GRCm38) missense probably damaging 1.00
R9222:Arap2 UTSW 5 62,671,078 (GRCm38) missense possibly damaging 0.96
R9281:Arap2 UTSW 5 62,749,505 (GRCm38) missense probably damaging 0.97
R9399:Arap2 UTSW 5 62,606,112 (GRCm38) missense possibly damaging 0.62
R9450:Arap2 UTSW 5 62,698,419 (GRCm38) missense probably benign 0.16
R9467:Arap2 UTSW 5 62,730,557 (GRCm38) missense probably benign 0.00
R9567:Arap2 UTSW 5 62,604,498 (GRCm38) missense probably benign 0.01
R9577:Arap2 UTSW 5 62,611,717 (GRCm38) missense probably damaging 1.00
R9626:Arap2 UTSW 5 62,749,535 (GRCm38) missense probably benign 0.00
R9688:Arap2 UTSW 5 62,714,766 (GRCm38) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTACACAAGGCAGCCTTAGAAAG -3'
(R):5'- CTCAGAAGATTCCAGCAAGGC -3'

Sequencing Primer
(F):5'- GGATGCTGAAAACACTGTTGC -3'
(R):5'- GGCACTTAGTACAAACACTGAATGTC -3'
Posted On 2015-04-30