Incidental Mutation 'R3942:Lypd6b'
ID 312892
Institutional Source Beutler Lab
Gene Symbol Lypd6b
Ensembl Gene ENSMUSG00000026765
Gene Name LY6/PLAUR domain containing 6B
Synonyms 2310010M24Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3942 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 49677700-49838861 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 49833552 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Isoleucine at position 64 (S64I)
Ref Sequence ENSEMBL: ENSMUSP00000028103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028103]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000028103
AA Change: S64I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028103
Gene: ENSMUSG00000026765
AA Change: S64I

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
LU 65 156 7.64e-2 SMART
low complexity region 167 177 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129867
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,330,908 (GRCm39) N6049S probably damaging Het
Aph1a C T 3: 95,801,573 (GRCm39) R31W probably damaging Het
Atp10b T C 11: 43,063,581 (GRCm39) V172A probably damaging Het
Atp13a2 T C 4: 140,733,733 (GRCm39) S1041P probably damaging Het
Best3 T A 10: 116,824,579 (GRCm39) F15Y possibly damaging Het
Brinp3 C A 1: 146,627,599 (GRCm39) D277E probably damaging Het
Crb1 A C 1: 139,265,211 (GRCm39) L69R possibly damaging Het
Crcp T C 5: 130,063,791 (GRCm39) probably null Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Hps3 T C 3: 20,051,103 (GRCm39) Y859C probably damaging Het
Irx5 C A 8: 93,086,314 (GRCm39) N132K probably damaging Het
Itgb2 A G 10: 77,393,867 (GRCm39) T436A probably benign Het
Kit A G 5: 75,769,978 (GRCm39) D130G probably benign Het
Krt12 A G 11: 99,312,922 (GRCm39) S41P unknown Het
Mpc1 T A 17: 8,507,420 (GRCm39) probably null Het
Or4c109 T A 2: 88,818,455 (GRCm39) L30F probably benign Het
Or5b95 A T 19: 12,657,768 (GRCm39) M99L probably benign Het
Pard3b T A 1: 62,198,611 (GRCm39) I233N probably damaging Het
Pcdh1 A G 18: 38,332,511 (GRCm39) V164A probably benign Het
Pclo A G 5: 14,729,932 (GRCm39) probably benign Het
Pkhd1l1 T C 15: 44,455,422 (GRCm39) probably null Het
Slco1a7 A G 6: 141,673,440 (GRCm39) I366T probably damaging Het
Spata31d1d T C 13: 59,875,276 (GRCm39) Q753R probably benign Het
Stxbp6 A G 12: 44,949,641 (GRCm39) probably null Het
Trav6-5 T C 14: 53,728,838 (GRCm39) S32P probably benign Het
Zp3r A C 1: 130,504,791 (GRCm39) D470E possibly damaging Het
Other mutations in Lypd6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Lypd6b APN 2 49,833,642 (GRCm39) splice site probably benign
R1056:Lypd6b UTSW 2 49,837,468 (GRCm39) missense possibly damaging 0.89
R1174:Lypd6b UTSW 2 49,833,609 (GRCm39) missense possibly damaging 0.89
R1510:Lypd6b UTSW 2 49,824,831 (GRCm39) missense probably damaging 0.98
R1518:Lypd6b UTSW 2 49,837,504 (GRCm39) missense probably damaging 0.99
R1550:Lypd6b UTSW 2 49,833,615 (GRCm39) missense probably damaging 1.00
R1864:Lypd6b UTSW 2 49,837,459 (GRCm39) missense possibly damaging 0.95
R4942:Lypd6b UTSW 2 49,836,132 (GRCm39) missense probably benign 0.25
R5988:Lypd6b UTSW 2 49,836,178 (GRCm39) missense probably damaging 1.00
R7329:Lypd6b UTSW 2 49,832,512 (GRCm39) missense probably benign 0.09
R7944:Lypd6b UTSW 2 49,833,612 (GRCm39) missense probably damaging 1.00
R7945:Lypd6b UTSW 2 49,833,612 (GRCm39) missense probably damaging 1.00
R9076:Lypd6b UTSW 2 49,837,534 (GRCm39) missense possibly damaging 0.75
R9421:Lypd6b UTSW 2 49,832,552 (GRCm39) missense probably benign 0.00
Z1177:Lypd6b UTSW 2 49,832,608 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGGAGCCATTTCATTTCAGGAC -3'
(R):5'- GATCCAGGACCCCATTAGAATC -3'

Sequencing Primer
(F):5'- GAGCCATTTCATTTCAGGACACAGG -3'
(R):5'- ATTAGAATCCCACTGGCCTGTG -3'
Posted On 2015-04-30