Incidental Mutation 'R4027:Vmn1r74'
ID 313031
Institutional Source Beutler Lab
Gene Symbol Vmn1r74
Ensembl Gene ENSMUSG00000047655
Gene Name vomeronasal 1 receptor 74
Synonyms V1rg5
MMRRC Submission 040850-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R4027 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 11580702-11581616 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 11580898 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 66 (T66K)
Ref Sequence ENSEMBL: ENSMUSP00000154746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050416] [ENSMUST00000228471]
AlphaFold Q8R290
Predicted Effect probably damaging
Transcript: ENSMUST00000050416
AA Change: T66K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000055148
Gene: ENSMUSG00000047655
AA Change: T66K

DomainStartEndE-ValueType
Pfam:7tm_1 22 290 1.3e-7 PFAM
Pfam:V1R 34 296 1.2e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210930
Predicted Effect probably damaging
Transcript: ENSMUST00000228471
AA Change: T66K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency 97% (60/62)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik A G 2: 35,270,408 (GRCm39) F98L probably damaging Het
Adam26b T C 8: 43,973,409 (GRCm39) N531S probably benign Het
Ahdc1 T C 4: 132,791,476 (GRCm39) S906P possibly damaging Het
Ank A G 15: 27,544,343 (GRCm39) N35D probably damaging Het
Ano10 A G 9: 122,081,994 (GRCm39) probably benign Het
Atp4a T C 7: 30,424,377 (GRCm39) probably null Het
C030005K15Rik T C 10: 97,561,404 (GRCm39) Y109C unknown Het
Carmil1 T A 13: 24,251,206 (GRCm39) probably benign Het
Ccl2 A G 11: 81,927,885 (GRCm39) R110G probably benign Het
Cntnap2 C A 6: 46,833,062 (GRCm39) F758L probably benign Het
Cog6 A C 3: 52,909,950 (GRCm39) D267E possibly damaging Het
Cyp4f37 G T 17: 32,850,646 (GRCm39) E366D probably benign Het
Dcun1d4 A G 5: 73,691,980 (GRCm39) D89G probably damaging Het
Dpep1 T C 8: 123,920,892 (GRCm39) V24A probably benign Het
Eefsec T C 6: 88,353,232 (GRCm39) I48V probably benign Het
Elmo2 G A 2: 165,136,169 (GRCm39) Q195* probably null Het
Ephb3 A G 16: 21,040,447 (GRCm39) D561G probably damaging Het
Erich2 C A 2: 70,343,134 (GRCm39) probably benign Het
Gatm A G 2: 122,427,927 (GRCm39) V362A probably damaging Het
Gdf10 A G 14: 33,654,572 (GRCm39) M360V probably damaging Het
Gpr141 T C 13: 19,935,995 (GRCm39) N260S probably benign Het
Hectd1 T A 12: 51,849,219 (GRCm39) probably null Het
Insrr A G 3: 87,716,906 (GRCm39) E682G probably benign Het
Itgax A G 7: 127,740,438 (GRCm39) I742V possibly damaging Het
Kcnh1 T C 1: 191,959,007 (GRCm39) V187A probably benign Het
Kdm6b G T 11: 69,297,094 (GRCm39) S419R possibly damaging Het
Kmt2a A T 9: 44,747,990 (GRCm39) probably benign Het
Krt10 A G 11: 99,277,019 (GRCm39) probably benign Het
Lct G A 1: 128,212,918 (GRCm39) R1912C probably benign Het
Lefty1 T C 1: 180,765,346 (GRCm39) S305P probably benign Het
Mast3 A G 8: 71,240,552 (GRCm39) L279P probably damaging Het
Mfsd4b3-ps T C 10: 39,823,343 (GRCm39) T306A probably benign Het
Mgam G A 6: 40,731,836 (GRCm39) R1351Q probably damaging Het
Mknk1 T A 4: 115,721,758 (GRCm39) F101I probably damaging Het
Mlc1 T C 15: 88,850,697 (GRCm39) I154V probably benign Het
Myo5b T C 18: 74,892,311 (GRCm39) I1685T possibly damaging Het
Nacc2 T A 2: 25,950,348 (GRCm39) M463L probably benign Het
Nek11 A C 9: 105,121,589 (GRCm39) Y443* probably null Het
Nme4 T C 17: 26,313,196 (GRCm39) probably null Het
Nova1 A G 12: 46,863,801 (GRCm39) probably benign Het
Or52h9 A T 7: 104,202,530 (GRCm39) I135F possibly damaging Het
Parp10 A G 15: 76,125,354 (GRCm39) probably null Het
Pkd1l3 T A 8: 110,350,603 (GRCm39) S483T possibly damaging Het
Plce1 T C 19: 38,512,709 (GRCm39) S3P probably damaging Het
Pnldc1 T C 17: 13,109,666 (GRCm39) D400G probably benign Het
Polr2b G A 5: 77,496,252 (GRCm39) R1141H possibly damaging Het
Prmt6 A G 3: 110,157,257 (GRCm39) I344T probably damaging Het
Psmd2 G A 16: 20,481,955 (GRCm39) G896D probably damaging Het
Ranbp17 C T 11: 33,450,718 (GRCm39) R73Q possibly damaging Het
Rcn1 G T 2: 105,229,395 (GRCm39) Y52* probably null Het
Reck T C 4: 43,922,931 (GRCm39) I402T probably damaging Het
Tecpr1 C A 5: 144,143,077 (GRCm39) A735S probably benign Het
Tshz1 T C 18: 84,032,954 (GRCm39) K485E possibly damaging Het
Ube4a G A 9: 44,861,198 (GRCm39) probably benign Het
Vldlr A G 19: 27,215,713 (GRCm39) T237A probably benign Het
Wdr49 C A 3: 75,230,972 (GRCm39) L563F probably benign Het
Zmym1 C T 4: 126,943,672 (GRCm39) V239I probably benign Het
Zmym5 T A 14: 57,035,268 (GRCm39) T267S probably benign Het
Other mutations in Vmn1r74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01608:Vmn1r74 APN 7 11,581,560 (GRCm39) missense probably damaging 0.98
IGL01673:Vmn1r74 APN 7 11,581,317 (GRCm39) missense possibly damaging 0.94
IGL03023:Vmn1r74 APN 7 11,581,257 (GRCm39) missense possibly damaging 0.46
IGL03409:Vmn1r74 APN 7 11,581,240 (GRCm39) missense probably damaging 0.99
R0393:Vmn1r74 UTSW 7 11,581,242 (GRCm39) missense possibly damaging 0.79
R1488:Vmn1r74 UTSW 7 11,581,510 (GRCm39) missense probably benign 0.02
R1707:Vmn1r74 UTSW 7 11,581,504 (GRCm39) missense probably damaging 0.98
R1998:Vmn1r74 UTSW 7 11,581,302 (GRCm39) missense probably damaging 1.00
R1999:Vmn1r74 UTSW 7 11,581,302 (GRCm39) missense probably damaging 1.00
R2139:Vmn1r74 UTSW 7 11,581,243 (GRCm39) missense probably damaging 1.00
R4576:Vmn1r74 UTSW 7 11,580,696 (GRCm39) splice site probably null
R4619:Vmn1r74 UTSW 7 11,581,403 (GRCm39) missense probably damaging 1.00
R4619:Vmn1r74 UTSW 7 11,581,398 (GRCm39) missense possibly damaging 0.61
R5371:Vmn1r74 UTSW 7 11,580,984 (GRCm39) missense probably damaging 1.00
R5606:Vmn1r74 UTSW 7 11,580,822 (GRCm39) missense probably benign 0.01
R6464:Vmn1r74 UTSW 7 11,581,131 (GRCm39) missense possibly damaging 0.87
R6901:Vmn1r74 UTSW 7 11,581,368 (GRCm39) missense probably benign 0.00
R6920:Vmn1r74 UTSW 7 11,581,575 (GRCm39) missense probably benign 0.01
R7223:Vmn1r74 UTSW 7 11,580,894 (GRCm39) nonsense probably null
R7231:Vmn1r74 UTSW 7 11,580,888 (GRCm39) missense probably benign 0.34
R7418:Vmn1r74 UTSW 7 11,581,081 (GRCm39) missense possibly damaging 0.88
R8135:Vmn1r74 UTSW 7 11,581,530 (GRCm39) missense probably benign 0.36
R8692:Vmn1r74 UTSW 7 11,580,972 (GRCm39) missense probably benign 0.03
R8748:Vmn1r74 UTSW 7 11,580,903 (GRCm39) missense probably benign 0.10
R9004:Vmn1r74 UTSW 7 11,580,840 (GRCm39) missense probably benign 0.00
R9258:Vmn1r74 UTSW 7 11,580,999 (GRCm39) missense possibly damaging 0.86
R9564:Vmn1r74 UTSW 7 11,581,534 (GRCm39) missense probably damaging 1.00
RF049:Vmn1r74 UTSW 7 11,581,067 (GRCm39) frame shift probably null
RF063:Vmn1r74 UTSW 7 11,581,067 (GRCm39) frame shift probably null
Z1176:Vmn1r74 UTSW 7 11,580,936 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACTGTATTACTCCAGTCTCAGATC -3'
(R):5'- GGTGGCTCTGTGTTTAAACATCATC -3'

Sequencing Primer
(F):5'- CTTCTTTAATAGGAATCAGGATGGC -3'
(R):5'- CCATCTGGAATAGTTGGGGC -3'
Posted On 2015-04-30