Incidental Mutation 'R4031:Vsig10l'
ID 313492
Institutional Source Beutler Lab
Gene Symbol Vsig10l
Ensembl Gene ENSMUSG00000070604
Gene Name V-set and immunoglobulin domain containing 10 like
Synonyms 2210412E05Rik
MMRRC Submission 040960-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.204) question?
Stock # R4031 (G1)
Quality Score 199
Status Validated
Chromosome 7
Chromosomal Location 43112575-43121443 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 43114798 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 333 (A333V)
Ref Sequence ENSEMBL: ENSMUSP00000144692 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107977] [ENSMUST00000203042] [ENSMUST00000203633] [ENSMUST00000203769] [ENSMUST00000204680]
AlphaFold D3YZF7
Predicted Effect possibly damaging
Transcript: ENSMUST00000107977
AA Change: A435V

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103611
Gene: ENSMUSG00000070604
AA Change: A435V

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 28 52 N/A INTRINSIC
IG 183 285 1.92e0 SMART
IG 298 383 2.15e-3 SMART
IGc2 406 465 4.19e-6 SMART
Blast:IG_like 582 649 1e-13 BLAST
transmembrane domain 764 786 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203042
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203152
Predicted Effect probably benign
Transcript: ENSMUST00000203633
SMART Domains Protein: ENSMUSP00000145061
Gene: ENSMUSG00000107482

DomainStartEndE-ValueType
ETF 26 216 2.7e-65 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000203769
AA Change: A333V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000144692
Gene: ENSMUSG00000070604
AA Change: A333V

DomainStartEndE-ValueType
IG 81 183 8.1e-3 SMART
IG 196 281 9.2e-6 SMART
IGc2 304 363 1.8e-8 SMART
Blast:IG_like 480 547 9e-14 BLAST
transmembrane domain 662 684 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204680
SMART Domains Protein: ENSMUSP00000145493
Gene: ENSMUSG00000107482

DomainStartEndE-ValueType
ETF 26 168 2.4e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205247
Meta Mutation Damage Score 0.2199 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 95% (52/55)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 G T 8: 87,244,077 (GRCm39) F1025L probably damaging Het
Acss2 C T 2: 155,399,130 (GRCm39) T477I probably damaging Het
Aplp2 G A 9: 31,069,026 (GRCm39) P601L probably benign Het
Arl2bp T C 8: 95,394,281 (GRCm39) I32T probably damaging Het
Avpi1 C A 19: 42,113,180 (GRCm39) probably benign Het
C030005K15Rik T C 10: 97,561,404 (GRCm39) Y109C unknown Het
Ccdc150 T A 1: 54,317,970 (GRCm39) M303K probably benign Het
Chrna5 T C 9: 54,905,370 (GRCm39) W61R probably damaging Het
Copa T C 1: 171,935,942 (GRCm39) V428A probably damaging Het
Crybb3 A G 5: 113,227,735 (GRCm39) Y29H probably damaging Het
Dcun1d4 A G 5: 73,691,980 (GRCm39) D89G probably damaging Het
Disp2 T C 2: 118,622,361 (GRCm39) I1031T probably benign Het
Elf1 A C 14: 79,806,723 (GRCm39) K161Q probably damaging Het
Fndc1 A T 17: 7,988,584 (GRCm39) Y1159* probably null Het
Hspa12a T C 19: 58,789,289 (GRCm39) N449S probably benign Het
Hyal4 A G 6: 24,756,223 (GRCm39) E147G probably damaging Het
Hydin T C 8: 111,336,679 (GRCm39) I5152T probably benign Het
Ighv9-1 C T 12: 114,057,844 (GRCm39) A19T probably benign Het
Kcnt1 T G 2: 25,806,060 (GRCm39) S1216R possibly damaging Het
Kdm5d T A Y: 916,910 (GRCm39) V435E probably damaging Het
Klhl30 G A 1: 91,288,879 (GRCm39) R546H probably benign Het
Lrp1b C T 2: 40,592,860 (GRCm39) G3753D probably benign Het
Ltbp3 G A 19: 5,804,050 (GRCm39) R854Q probably benign Het
Macf1 A G 4: 123,275,105 (GRCm39) L6303P probably damaging Het
Mblac2 T C 13: 81,898,208 (GRCm39) S195P possibly damaging Het
Mindy3 A C 2: 12,405,894 (GRCm39) probably null Het
Neurod1 C T 2: 79,284,370 (GRCm39) D338N probably benign Het
Polr1e A T 4: 45,018,685 (GRCm39) E5V probably benign Het
Polr2b G A 5: 77,496,252 (GRCm39) R1141H possibly damaging Het
Ppp2r2a T C 14: 67,266,425 (GRCm39) S79G probably damaging Het
Psmd2 G A 16: 20,481,955 (GRCm39) G896D probably damaging Het
Rap1gds1 T C 3: 138,756,353 (GRCm39) probably benign Het
Rsph10b A G 5: 143,922,486 (GRCm39) probably null Het
Slc26a10 A G 10: 127,013,871 (GRCm39) V297A possibly damaging Het
Slc26a5 T C 5: 22,052,189 (GRCm39) K47E probably damaging Het
Slurp1 T C 15: 74,599,336 (GRCm39) E58G probably damaging Het
Spo11 T A 2: 172,828,625 (GRCm39) probably benign Het
Tm9sf4 T C 2: 153,040,264 (GRCm39) probably benign Het
Trak1 T C 9: 121,280,736 (GRCm39) I272T probably damaging Het
Tshz1 T C 18: 84,032,954 (GRCm39) K485E possibly damaging Het
Ttn T A 2: 76,585,168 (GRCm39) I22042F probably damaging Het
Unc79 T A 12: 103,039,018 (GRCm39) S671T possibly damaging Het
Usp43 G T 11: 67,804,659 (GRCm39) A186D probably damaging Het
Vmn2r107 G A 17: 20,595,483 (GRCm39) V679I probably benign Het
Vwa3a G A 7: 120,367,455 (GRCm39) probably null Het
Wdr49 C A 3: 75,230,972 (GRCm39) L563F probably benign Het
Wnk1 T C 6: 119,928,029 (GRCm39) T1141A probably damaging Het
Zfp236 T A 18: 82,642,590 (GRCm39) E1052V probably damaging Het
Zfp317 A T 9: 19,558,008 (GRCm39) H163L possibly damaging Het
Zfp975 G A 7: 42,312,377 (GRCm39) Q79* probably null Het
Other mutations in Vsig10l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01319:Vsig10l APN 7 43,114,678 (GRCm39) missense probably damaging 1.00
IGL01390:Vsig10l APN 7 43,115,889 (GRCm39) missense probably damaging 0.97
IGL02401:Vsig10l APN 7 43,113,468 (GRCm39) missense probably damaging 1.00
IGL02404:Vsig10l APN 7 43,113,171 (GRCm39) missense possibly damaging 0.85
IGL02514:Vsig10l APN 7 43,113,338 (GRCm39) missense probably benign 0.02
IGL02636:Vsig10l APN 7 43,113,002 (GRCm39) missense possibly damaging 0.53
IGL02805:Vsig10l APN 7 43,114,666 (GRCm39) missense probably damaging 1.00
IGL02823:Vsig10l APN 7 43,115,888 (GRCm39) missense probably damaging 1.00
IGL02827:Vsig10l APN 7 43,114,293 (GRCm39) missense probably damaging 1.00
R0111:Vsig10l UTSW 7 43,117,525 (GRCm39) missense probably damaging 0.97
R0394:Vsig10l UTSW 7 43,114,879 (GRCm39) missense probably damaging 0.97
R0465:Vsig10l UTSW 7 43,116,866 (GRCm39) missense probably damaging 1.00
R0632:Vsig10l UTSW 7 43,113,561 (GRCm39) missense probably damaging 0.97
R1689:Vsig10l UTSW 7 43,114,792 (GRCm39) missense possibly damaging 0.93
R1991:Vsig10l UTSW 7 43,116,892 (GRCm39) missense possibly damaging 0.89
R2103:Vsig10l UTSW 7 43,116,892 (GRCm39) missense possibly damaging 0.89
R2358:Vsig10l UTSW 7 43,118,185 (GRCm39) missense probably benign 0.00
R3015:Vsig10l UTSW 7 43,116,881 (GRCm39) missense possibly damaging 0.73
R4024:Vsig10l UTSW 7 43,117,510 (GRCm39) missense probably benign 0.33
R4807:Vsig10l UTSW 7 43,113,173 (GRCm39) missense possibly damaging 0.53
R5020:Vsig10l UTSW 7 43,114,741 (GRCm39) nonsense probably null
R5261:Vsig10l UTSW 7 43,120,274 (GRCm39) missense probably damaging 1.00
R5317:Vsig10l UTSW 7 43,114,247 (GRCm39) missense probably damaging 1.00
R5426:Vsig10l UTSW 7 43,114,247 (GRCm39) missense probably damaging 0.97
R5656:Vsig10l UTSW 7 43,113,575 (GRCm39) nonsense probably null
R5842:Vsig10l UTSW 7 43,118,396 (GRCm39) missense probably benign 0.15
R6012:Vsig10l UTSW 7 43,117,439 (GRCm39) missense probably damaging 1.00
R6235:Vsig10l UTSW 7 43,118,396 (GRCm39) missense probably benign 0.15
R6309:Vsig10l UTSW 7 43,120,397 (GRCm39) splice site probably null
R6994:Vsig10l UTSW 7 43,114,491 (GRCm39) missense possibly damaging 0.71
R7250:Vsig10l UTSW 7 43,113,099 (GRCm39) missense probably benign
R7397:Vsig10l UTSW 7 43,117,431 (GRCm39) missense probably damaging 1.00
R7767:Vsig10l UTSW 7 43,113,141 (GRCm39) missense probably damaging 0.96
R7956:Vsig10l UTSW 7 43,117,494 (GRCm39) missense probably benign
R8086:Vsig10l UTSW 7 43,114,876 (GRCm39) missense possibly damaging 0.92
R8139:Vsig10l UTSW 7 43,113,153 (GRCm39) missense probably benign 0.00
R8297:Vsig10l UTSW 7 43,113,531 (GRCm39) missense possibly damaging 0.50
R8341:Vsig10l UTSW 7 43,113,378 (GRCm39) missense probably damaging 1.00
R8519:Vsig10l UTSW 7 43,114,326 (GRCm39) missense probably benign 0.33
R8925:Vsig10l UTSW 7 43,116,020 (GRCm39) missense probably benign 0.41
R8927:Vsig10l UTSW 7 43,116,020 (GRCm39) missense probably benign 0.41
R8948:Vsig10l UTSW 7 43,117,623 (GRCm39) missense possibly damaging 0.53
R9157:Vsig10l UTSW 7 43,112,948 (GRCm39) missense
R9203:Vsig10l UTSW 7 43,112,657 (GRCm39) start codon destroyed probably null
R9481:Vsig10l UTSW 7 43,112,795 (GRCm39) nonsense probably null
X0028:Vsig10l UTSW 7 43,112,788 (GRCm39) utr 3 prime probably benign
X0067:Vsig10l UTSW 7 43,116,914 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAGTTCTTTAACAGTCCAACCC -3'
(R):5'- TTTGCTGACACCCAGGACTC -3'

Sequencing Primer
(F):5'- TCCTGTCATTAGGGTCTCC -3'
(R):5'- TGACACCCAGGACTCCATGTG -3'
Posted On 2015-04-30