Incidental Mutation 'R4032:Zfp655'
| ID |
313529 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp655
|
| Ensembl Gene |
ENSMUSG00000007812 |
| Gene Name |
zinc finger protein 655 |
| Synonyms |
2700038I16Rik, 9030409O18Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.353)
|
| Stock # |
R4032 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
145168525-145184112 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 145180858 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 239
(T239A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128969
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167316]
[ENSMUST00000199322]
|
| AlphaFold |
Q9CZP3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167316
AA Change: T239A
PolyPhen 2
Score 0.505 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000128969
Gene: ENSMUSG00000007812
AA Change: T239A
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
243 |
265 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
299 |
328 |
1.38e2 |
SMART |
|
ZnF_C2H2
|
334 |
356 |
6.78e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
3.99e0 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
1.01e-1 |
SMART |
|
low complexity region
|
463 |
475 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
495 |
517 |
6.47e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199322
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alkbh2 |
C |
T |
5: 114,262,287 (GRCm39) |
E148K |
probably damaging |
Het |
| Arhgap17 |
G |
T |
7: 122,879,289 (GRCm39) |
|
probably benign |
Het |
| Atp13a4 |
T |
A |
16: 29,237,389 (GRCm39) |
M846L |
probably damaging |
Het |
| Capn5 |
G |
T |
7: 97,778,453 (GRCm39) |
Q389K |
probably damaging |
Het |
| Cdkl3 |
T |
A |
11: 51,902,118 (GRCm39) |
I109N |
probably damaging |
Het |
| Cry2 |
T |
C |
2: 92,244,172 (GRCm39) |
I334V |
probably benign |
Het |
| Cs |
T |
C |
10: 128,196,913 (GRCm39) |
L436P |
probably damaging |
Het |
| D17H6S53E |
T |
C |
17: 35,346,355 (GRCm39) |
S89P |
probably benign |
Het |
| Dync1h1 |
C |
T |
12: 110,584,483 (GRCm39) |
Q629* |
probably null |
Het |
| H4c12 |
T |
C |
13: 21,934,588 (GRCm39) |
I30V |
possibly damaging |
Het |
| Itpka |
C |
T |
2: 119,573,082 (GRCm39) |
P75S |
probably benign |
Het |
| Lyst |
C |
T |
13: 13,791,250 (GRCm39) |
H38Y |
probably damaging |
Het |
| Mansc4 |
T |
C |
6: 146,976,678 (GRCm39) |
K313E |
probably benign |
Het |
| Megf6 |
T |
A |
4: 154,261,550 (GRCm39) |
C58* |
probably null |
Het |
| Mtor |
T |
C |
4: 148,621,209 (GRCm39) |
V1869A |
probably benign |
Het |
| Mybpc1 |
T |
C |
10: 88,365,426 (GRCm39) |
D899G |
probably benign |
Het |
| Nek10 |
C |
A |
14: 14,853,877 (GRCm38) |
|
probably null |
Het |
| Nfkb1 |
T |
C |
3: 135,300,110 (GRCm39) |
S657G |
possibly damaging |
Het |
| Or10d5j |
T |
C |
9: 39,867,629 (GRCm39) |
T213A |
probably benign |
Het |
| Or2a25 |
A |
T |
6: 42,888,559 (GRCm39) |
Y34F |
probably benign |
Het |
| Or4m1 |
T |
A |
14: 50,557,767 (GRCm39) |
D175V |
possibly damaging |
Het |
| Or4n5 |
G |
T |
14: 50,132,433 (GRCm39) |
H275Q |
probably benign |
Het |
| Or51f23 |
A |
G |
7: 102,453,396 (GRCm39) |
K237R |
probably benign |
Het |
| Pabir1 |
C |
T |
19: 24,454,106 (GRCm39) |
M205I |
probably benign |
Het |
| Pde1b |
A |
G |
15: 103,429,753 (GRCm39) |
D82G |
probably damaging |
Het |
| Pdzrn4 |
C |
T |
15: 92,667,414 (GRCm39) |
T522M |
probably damaging |
Het |
| Ptpro |
C |
A |
6: 137,438,740 (GRCm39) |
N373K |
probably damaging |
Het |
| Ptprs |
T |
C |
17: 56,720,386 (GRCm39) |
Y1478C |
probably damaging |
Het |
| Sdc2 |
A |
T |
15: 33,017,323 (GRCm39) |
I46F |
probably damaging |
Het |
| Sergef |
C |
A |
7: 46,092,726 (GRCm39) |
E428* |
probably null |
Het |
| Stk36 |
A |
G |
1: 74,665,207 (GRCm39) |
S651G |
probably benign |
Het |
| Ubr5 |
A |
G |
15: 38,025,081 (GRCm39) |
V559A |
|
Het |
| Ugt8a |
C |
A |
3: 125,667,807 (GRCm39) |
D345Y |
probably damaging |
Het |
| Usp44 |
A |
G |
10: 93,683,127 (GRCm39) |
|
probably benign |
Het |
| Vps13a |
A |
T |
19: 16,594,263 (GRCm39) |
L3156Q |
probably damaging |
Het |
| Zfp87 |
T |
C |
13: 74,520,449 (GRCm39) |
T210A |
possibly damaging |
Het |
|
| Other mutations in Zfp655 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Zfp655
|
APN |
5 |
145,180,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01679:Zfp655
|
APN |
5 |
145,180,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02379:Zfp655
|
APN |
5 |
145,180,765 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02647:Zfp655
|
APN |
5 |
145,179,816 (GRCm39) |
missense |
probably benign |
|
|
R0104:Zfp655
|
UTSW |
5 |
145,180,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0104:Zfp655
|
UTSW |
5 |
145,180,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Zfp655
|
UTSW |
5 |
145,181,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Zfp655
|
UTSW |
5 |
145,180,867 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R1528:Zfp655
|
UTSW |
5 |
145,181,411 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2076:Zfp655
|
UTSW |
5 |
145,181,410 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2119:Zfp655
|
UTSW |
5 |
145,181,594 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2375:Zfp655
|
UTSW |
5 |
145,181,206 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2403:Zfp655
|
UTSW |
5 |
145,181,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4532:Zfp655
|
UTSW |
5 |
145,181,507 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4880:Zfp655
|
UTSW |
5 |
145,181,168 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5484:Zfp655
|
UTSW |
5 |
145,180,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5529:Zfp655
|
UTSW |
5 |
145,181,546 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6193:Zfp655
|
UTSW |
5 |
145,181,586 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6195:Zfp655
|
UTSW |
5 |
145,180,572 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7050:Zfp655
|
UTSW |
5 |
145,181,545 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7471:Zfp655
|
UTSW |
5 |
145,181,542 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7612:Zfp655
|
UTSW |
5 |
145,173,999 (GRCm39) |
missense |
unknown |
|
|
R7626:Zfp655
|
UTSW |
5 |
145,173,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7989:Zfp655
|
UTSW |
5 |
145,181,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8557:Zfp655
|
UTSW |
5 |
145,180,835 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8805:Zfp655
|
UTSW |
5 |
145,181,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9602:Zfp655
|
UTSW |
5 |
145,181,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9664:Zfp655
|
UTSW |
5 |
145,180,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zfp655
|
UTSW |
5 |
145,180,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCCACACTTGATACAGATCAGAG -3'
(R):5'- CATCACAGGACTTATCAGACGC -3'
Sequencing Primer
(F):5'- CACACTTGATACAGATCAGAGAGTTC -3'
(R):5'- CAGACGCTTCACATTTGTAGG -3'
|
| Posted On |
2015-04-30 |
Incidental Mutation