Incidental Mutation 'R4032:Sdc2'
ID 313554
Institutional Source Beutler Lab
Gene Symbol Sdc2
Ensembl Gene ENSMUSG00000022261
Gene Name syndecan 2
Synonyms Hspg1, Synd2, fibroglycan, 4833414L08Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4032 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 32920869-33034867 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 33017323 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 46 (I46F)
Ref Sequence ENSEMBL: ENSMUSP00000022871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022871]
AlphaFold P43407
Predicted Effect probably damaging
Transcript: ENSMUST00000022871
AA Change: I46F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022871
Gene: ENSMUSG00000022261
AA Change: I46F

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 47 62 N/A INTRINSIC
4.1m 169 187 3.69e-3 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Arhgap17 G T 7: 122,879,289 (GRCm39) probably benign Het
Atp13a4 T A 16: 29,237,389 (GRCm39) M846L probably damaging Het
Capn5 G T 7: 97,778,453 (GRCm39) Q389K probably damaging Het
Cdkl3 T A 11: 51,902,118 (GRCm39) I109N probably damaging Het
Cry2 T C 2: 92,244,172 (GRCm39) I334V probably benign Het
Cs T C 10: 128,196,913 (GRCm39) L436P probably damaging Het
D17H6S53E T C 17: 35,346,355 (GRCm39) S89P probably benign Het
Dync1h1 C T 12: 110,584,483 (GRCm39) Q629* probably null Het
H4c12 T C 13: 21,934,588 (GRCm39) I30V possibly damaging Het
Itpka C T 2: 119,573,082 (GRCm39) P75S probably benign Het
Lyst C T 13: 13,791,250 (GRCm39) H38Y probably damaging Het
Mansc4 T C 6: 146,976,678 (GRCm39) K313E probably benign Het
Megf6 T A 4: 154,261,550 (GRCm39) C58* probably null Het
Mtor T C 4: 148,621,209 (GRCm39) V1869A probably benign Het
Mybpc1 T C 10: 88,365,426 (GRCm39) D899G probably benign Het
Nek10 C A 14: 14,853,877 (GRCm38) probably null Het
Nfkb1 T C 3: 135,300,110 (GRCm39) S657G possibly damaging Het
Or10d5j T C 9: 39,867,629 (GRCm39) T213A probably benign Het
Or2a25 A T 6: 42,888,559 (GRCm39) Y34F probably benign Het
Or4m1 T A 14: 50,557,767 (GRCm39) D175V possibly damaging Het
Or4n5 G T 14: 50,132,433 (GRCm39) H275Q probably benign Het
Or51f23 A G 7: 102,453,396 (GRCm39) K237R probably benign Het
Pabir1 C T 19: 24,454,106 (GRCm39) M205I probably benign Het
Pde1b A G 15: 103,429,753 (GRCm39) D82G probably damaging Het
Pdzrn4 C T 15: 92,667,414 (GRCm39) T522M probably damaging Het
Ptpro C A 6: 137,438,740 (GRCm39) N373K probably damaging Het
Ptprs T C 17: 56,720,386 (GRCm39) Y1478C probably damaging Het
Sergef C A 7: 46,092,726 (GRCm39) E428* probably null Het
Stk36 A G 1: 74,665,207 (GRCm39) S651G probably benign Het
Ubr5 A G 15: 38,025,081 (GRCm39) V559A Het
Ugt8a C A 3: 125,667,807 (GRCm39) D345Y probably damaging Het
Usp44 A G 10: 93,683,127 (GRCm39) probably benign Het
Vps13a A T 19: 16,594,263 (GRCm39) L3156Q probably damaging Het
Zfp655 A G 5: 145,180,858 (GRCm39) T239A possibly damaging Het
Zfp87 T C 13: 74,520,449 (GRCm39) T210A possibly damaging Het
Other mutations in Sdc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0510:Sdc2 UTSW 15 33,017,235 (GRCm39) splice site probably benign
R1743:Sdc2 UTSW 15 33,028,224 (GRCm39) missense probably benign
R4577:Sdc2 UTSW 15 33,017,278 (GRCm39) missense probably damaging 1.00
R4859:Sdc2 UTSW 15 33,032,602 (GRCm39) missense probably damaging 1.00
R5800:Sdc2 UTSW 15 33,028,290 (GRCm39) missense probably benign 0.02
R5918:Sdc2 UTSW 15 33,028,313 (GRCm39) missense probably benign 0.12
R6782:Sdc2 UTSW 15 33,028,281 (GRCm39) missense probably damaging 0.96
R7757:Sdc2 UTSW 15 33,028,233 (GRCm39) missense possibly damaging 0.51
R8838:Sdc2 UTSW 15 33,023,897 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCCGGGGTACTGGTTAGTTC -3'
(R):5'- CCTTATGAGTTGCTGTCAGGTG -3'

Sequencing Primer
(F):5'- GTGTGACCCATCCAATAGCTG -3'
(R):5'- CTGAGACTCAGCAAAGTTAGGTTCC -3'
Posted On 2015-04-30