Incidental Mutation 'R4035:Or8b4'
ID 313674
Institutional Source Beutler Lab
Gene Symbol Or8b4
Ensembl Gene ENSMUSG00000066747
Gene Name olfactory receptor family 8 subfamily B member 4
Synonyms MOR163-1, GA_x6K02T2PVTD-31600511-31601440, Olfr878
MMRRC Submission 041613-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.209) question?
Stock # R4035 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 37829844-37830908 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 37829937 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086061] [ENSMUST00000212878] [ENSMUST00000214263] [ENSMUST00000216723]
AlphaFold Q9EQA9
Predicted Effect probably benign
Transcript: ENSMUST00000086061
SMART Domains Protein: ENSMUSP00000083228
Gene: ENSMUSG00000066747

DomainStartEndE-ValueType
Pfam:7tm_4 36 312 1.4e-46 PFAM
Pfam:7tm_1 46 294 5.6e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212878
Predicted Effect probably benign
Transcript: ENSMUST00000214263
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214813
Predicted Effect probably benign
Transcript: ENSMUST00000216723
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013D24Rik A G 6: 124,333,879 (GRCm39) F34L probably benign Het
Abcb8 A G 5: 24,605,619 (GRCm39) S168G probably benign Het
Ano5 A G 7: 51,216,233 (GRCm39) probably benign Het
Api5 C T 2: 94,255,958 (GRCm39) R243Q possibly damaging Het
Bhlhe41 A G 6: 145,808,754 (GRCm39) S353P probably benign Het
Ccdc88c G A 12: 100,896,783 (GRCm39) A1389V possibly damaging Het
Cep350 T C 1: 155,835,541 (GRCm39) T52A probably benign Het
Coro2b A G 9: 62,333,071 (GRCm39) probably benign Het
Ctcf A T 8: 106,390,789 (GRCm39) E132V possibly damaging Het
Cwf19l2 A T 9: 3,456,803 (GRCm39) H712L probably benign Het
Cxcl2 A T 5: 91,052,272 (GRCm39) Q87L possibly damaging Het
Dop1a T C 9: 86,376,486 (GRCm39) V240A probably damaging Het
Etfdh C T 3: 79,521,018 (GRCm39) V294I probably benign Het
Fnip2 C T 3: 79,386,808 (GRCm39) V973I probably benign Het
Fyco1 T C 9: 123,630,348 (GRCm39) T1286A probably benign Het
Gbp10 T A 5: 105,372,324 (GRCm39) E145D possibly damaging Het
Gsdme A T 6: 50,206,428 (GRCm39) N138K possibly damaging Het
Hcn4 A G 9: 58,751,172 (GRCm39) D266G probably benign Het
Henmt1 T C 3: 108,866,001 (GRCm39) V199A probably damaging Het
Hmcn2 A T 2: 31,226,624 (GRCm39) K200* probably null Het
Hmgcr C G 13: 96,787,571 (GRCm39) L852F probably damaging Het
Ifi203 T A 1: 173,757,040 (GRCm39) probably benign Het
Isl2 A G 9: 55,449,754 (GRCm39) S119G probably benign Het
Krba1 A G 6: 48,388,614 (GRCm39) N538D probably damaging Het
Lcorl A T 5: 45,891,383 (GRCm39) N323K possibly damaging Het
Mfsd2b A G 12: 4,920,578 (GRCm39) S80P probably damaging Het
Ndst4 C T 3: 125,232,385 (GRCm39) T318M probably damaging Het
Nlrp4f T C 13: 65,341,821 (GRCm39) N608S probably benign Het
Nolc1 GCA GCACCA 19: 46,069,797 (GRCm39) probably benign Het
Or6d12 A G 6: 116,493,590 (GRCm39) N284S possibly damaging Het
Osbpl2 G A 2: 179,803,353 (GRCm39) R475H probably damaging Het
Ppfibp1 A G 6: 146,898,334 (GRCm39) K97E probably damaging Het
Pramel26 T A 4: 143,537,026 (GRCm39) D435V probably benign Het
Prpsap1 A T 11: 116,363,834 (GRCm39) M263K probably benign Het
Prtg G T 9: 72,749,991 (GRCm39) E132* probably null Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Rttn T C 18: 89,013,777 (GRCm39) V482A probably benign Het
Samsn1 A G 16: 75,706,073 (GRCm39) M1T probably null Het
Scel A G 14: 103,767,440 (GRCm39) N33S probably damaging Het
Sema4g A T 19: 44,989,853 (GRCm39) Y644F probably damaging Het
Slc39a10 G A 1: 46,851,234 (GRCm39) T752M probably damaging Het
Snx27 T C 3: 94,431,551 (GRCm39) D281G probably damaging Het
Spesp1 T A 9: 62,180,318 (GRCm39) I197L probably benign Het
Srsf4 C T 4: 131,627,413 (GRCm39) probably benign Het
Tpgs1 A G 10: 79,505,199 (GRCm39) probably null Het
Trpc2 G A 7: 101,733,711 (GRCm39) S220N probably damaging Het
Ttk C A 9: 83,736,890 (GRCm39) P450T possibly damaging Het
Ttn T G 2: 76,740,165 (GRCm39) Q3458P probably benign Het
Ube2z A G 11: 95,951,893 (GRCm39) F152L probably damaging Het
Utp20 C T 10: 88,598,668 (GRCm39) V103I probably benign Het
Zfa-ps T A 10: 52,420,636 (GRCm39) noncoding transcript Het
Zfp267 T G 3: 36,218,989 (GRCm39) H337Q possibly damaging Het
Other mutations in Or8b4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Or8b4 APN 9 37,830,346 (GRCm39) missense probably damaging 1.00
IGL01354:Or8b4 APN 9 37,830,840 (GRCm39) missense possibly damaging 0.74
R0399:Or8b4 UTSW 9 37,830,849 (GRCm39) missense possibly damaging 0.85
R1537:Or8b4 UTSW 9 37,830,570 (GRCm39) missense probably benign 0.24
R3737:Or8b4 UTSW 9 37,829,937 (GRCm39) splice site probably benign
R4675:Or8b4 UTSW 9 37,830,882 (GRCm39) makesense probably null
R4700:Or8b4 UTSW 9 37,830,217 (GRCm39) missense possibly damaging 0.77
R5719:Or8b4 UTSW 9 37,830,647 (GRCm39) missense probably damaging 1.00
R5824:Or8b4 UTSW 9 37,830,861 (GRCm39) missense probably benign 0.00
R5940:Or8b4 UTSW 9 37,830,733 (GRCm39) missense probably damaging 1.00
R6116:Or8b4 UTSW 9 37,829,955 (GRCm39) start codon destroyed probably null 0.94
R6705:Or8b4 UTSW 9 37,830,080 (GRCm39) missense probably damaging 1.00
R7075:Or8b4 UTSW 9 37,830,370 (GRCm39) missense probably benign 0.09
R7470:Or8b4 UTSW 9 37,830,592 (GRCm39) missense probably damaging 1.00
R8057:Or8b4 UTSW 9 37,830,460 (GRCm39) missense probably benign 0.00
R9102:Or8b4 UTSW 9 37,829,992 (GRCm39) missense probably damaging 1.00
R9204:Or8b4 UTSW 9 37,830,670 (GRCm39) missense probably damaging 1.00
R9254:Or8b4 UTSW 9 37,830,447 (GRCm39) missense probably damaging 1.00
R9379:Or8b4 UTSW 9 37,830,447 (GRCm39) missense probably damaging 1.00
R9504:Or8b4 UTSW 9 37,830,163 (GRCm39) missense probably damaging 1.00
R9711:Or8b4 UTSW 9 37,830,066 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCAAGAACAGAATCCTTGTTATC -3'
(R):5'- ACCCAATTAAGGTGATCAGTCC -3'

Sequencing Primer
(F):5'- GTCCATGGGAAATGAGCTATGCTC -3'
(R):5'- GGTGATCAGTCCCAAATTGC -3'
Posted On 2015-04-30