Incidental Mutation 'R4036:Vmn1r219'
ID 313725
Institutional Source Beutler Lab
Gene Symbol Vmn1r219
Ensembl Gene ENSMUSG00000061376
Gene Name vomeronasal 1 receptor 219
Synonyms V1rh13
MMRRC Submission 040963-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R4036 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 23346813-23347751 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23347272 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 154 (M154V)
Ref Sequence ENSEMBL: ENSMUSP00000154240 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076180] [ENSMUST00000226845] [ENSMUST00000227388] [ENSMUST00000228113] [ENSMUST00000228666]
AlphaFold Q8R271
Predicted Effect probably benign
Transcript: ENSMUST00000076180
AA Change: M154V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000075537
Gene: ENSMUSG00000061376
AA Change: M154V

DomainStartEndE-ValueType
Pfam:TAS2R 2 301 3.4e-7 PFAM
Pfam:V1R 33 297 3e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226845
AA Change: M154V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227388
AA Change: M154V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000228113
AA Change: M154V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000228666
AA Change: M154V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency 100% (33/33)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544M13Rik T C 13: 114,744,205 (GRCm39) noncoding transcript Het
Ahctf1 T C 1: 179,590,181 (GRCm39) Q1364R possibly damaging Het
Anxa2 A G 9: 69,395,352 (GRCm39) N265S probably damaging Het
Bcan A G 3: 87,903,423 (GRCm39) probably null Het
Cntln A G 4: 84,924,725 (GRCm39) Y610C probably damaging Het
Cyp39a1 C A 17: 43,987,831 (GRCm39) A99E probably damaging Het
Drc1 A G 5: 30,504,526 (GRCm39) I223V probably benign Het
Eef2kmt A T 16: 5,063,135 (GRCm39) V335D probably damaging Het
Fanci T C 7: 79,094,570 (GRCm39) L1167P probably damaging Het
Glb1l3 A C 9: 26,740,343 (GRCm39) M329R probably damaging Het
Gns C A 10: 121,207,095 (GRCm39) T72N probably damaging Het
Hspa2 T C 12: 76,452,542 (GRCm39) V412A probably damaging Het
Klk1b8 A G 7: 43,447,511 (GRCm39) I9V probably null Het
Map4 A G 9: 109,861,283 (GRCm39) T216A possibly damaging Het
Metrn T C 17: 26,013,984 (GRCm39) T281A probably benign Het
Mid1-ps1 G A Y: 90,773,563 (GRCm39) noncoding transcript Het
Ndc1 G A 4: 107,268,269 (GRCm39) D602N probably benign Het
Nsd1 A G 13: 55,361,524 (GRCm39) D164G possibly damaging Het
Or5ac22 T A 16: 59,135,113 (GRCm39) H219L probably benign Het
Pcdha8 T C 18: 37,125,914 (GRCm39) M132T probably benign Het
Pomt2 A G 12: 87,158,296 (GRCm39) probably null Het
Prrt3 AGGGGG AGGGG 6: 113,474,641 (GRCm39) probably null Het
Rfx6 T A 10: 51,602,842 (GRCm39) H786Q probably damaging Het
Scn4a A C 11: 106,212,883 (GRCm39) L1374R possibly damaging Het
Slc16a9 C T 10: 70,110,786 (GRCm39) T124M probably damaging Het
Slc46a2 A T 4: 59,913,818 (GRCm39) F368L probably damaging Het
St18 T A 1: 6,898,010 (GRCm39) I604K probably damaging Het
Ttn A G 2: 76,548,497 (GRCm39) V31935A possibly damaging Het
Urb1 T C 16: 90,584,974 (GRCm39) H549R probably benign Het
Zfp575 G A 7: 24,285,440 (GRCm39) S67L possibly damaging Het
Other mutations in Vmn1r219
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02517:Vmn1r219 APN 13 23,347,266 (GRCm39) missense probably benign 0.01
IGL03339:Vmn1r219 APN 13 23,347,580 (GRCm39) missense possibly damaging 0.88
R0662:Vmn1r219 UTSW 13 23,347,623 (GRCm39) missense possibly damaging 0.51
R1144:Vmn1r219 UTSW 13 23,347,383 (GRCm39) missense probably damaging 1.00
R4762:Vmn1r219 UTSW 13 23,346,999 (GRCm39) nonsense probably null
R5311:Vmn1r219 UTSW 13 23,347,063 (GRCm39) missense probably damaging 1.00
R6488:Vmn1r219 UTSW 13 23,347,135 (GRCm39) missense probably benign 0.02
R7157:Vmn1r219 UTSW 13 23,347,525 (GRCm39) missense probably damaging 1.00
R7305:Vmn1r219 UTSW 13 23,347,314 (GRCm39) missense probably benign
R7875:Vmn1r219 UTSW 13 23,347,363 (GRCm39) missense possibly damaging 0.58
R8753:Vmn1r219 UTSW 13 23,347,191 (GRCm39) missense probably damaging 1.00
R9290:Vmn1r219 UTSW 13 23,347,399 (GRCm39) missense probably damaging 1.00
R9345:Vmn1r219 UTSW 13 23,346,769 (GRCm39) start gained probably benign
R9353:Vmn1r219 UTSW 13 23,346,902 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCAGTTTCCTCACTGTGGTC -3'
(R):5'- GAGGACACTTTGAGCAGCTC -3'

Sequencing Primer
(F):5'- TGGTCCAGGCCATCATCATCAG -3'
(R):5'- TCTCAGCTCAGGGGGAGTTC -3'
Posted On 2015-04-30