Incidental Mutation 'R4036:Metrn'
ID 313731
Institutional Source Beutler Lab
Gene Symbol Metrn
Ensembl Gene ENSMUSG00000002274
Gene Name meteorin, glial cell differentiation regulator
Synonyms 1810034B16Rik
MMRRC Submission 040963-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.318) question?
Stock # R4036 (G1)
Quality Score 155
Status Validated
Chromosome 17
Chromosomal Location 26013545-26016019 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26013984 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 281 (T281A)
Ref Sequence ENSEMBL: ENSMUSP00000127275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002344] [ENSMUST00000072735] [ENSMUST00000095500] [ENSMUST00000165838]
AlphaFold Q8C1Q4
Predicted Effect probably benign
Transcript: ENSMUST00000002344
AA Change: T281A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000002344
Gene: ENSMUSG00000002274
AA Change: T281A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000072735
SMART Domains Protein: ENSMUSP00000072518
Gene: ENSMUSG00000057411

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
SCOP:d1f3la_ 65 141 2e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000095500
SMART Domains Protein: ENSMUSP00000093155
Gene: ENSMUSG00000071202

DomainStartEndE-ValueType
Pfam:DUF4472 63 190 5.5e-23 PFAM
coiled coil region 364 408 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165838
AA Change: T281A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000127275
Gene: ENSMUSG00000002274
AA Change: T281A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544M13Rik T C 13: 114,744,205 (GRCm39) noncoding transcript Het
Ahctf1 T C 1: 179,590,181 (GRCm39) Q1364R possibly damaging Het
Anxa2 A G 9: 69,395,352 (GRCm39) N265S probably damaging Het
Bcan A G 3: 87,903,423 (GRCm39) probably null Het
Cntln A G 4: 84,924,725 (GRCm39) Y610C probably damaging Het
Cyp39a1 C A 17: 43,987,831 (GRCm39) A99E probably damaging Het
Drc1 A G 5: 30,504,526 (GRCm39) I223V probably benign Het
Eef2kmt A T 16: 5,063,135 (GRCm39) V335D probably damaging Het
Fanci T C 7: 79,094,570 (GRCm39) L1167P probably damaging Het
Glb1l3 A C 9: 26,740,343 (GRCm39) M329R probably damaging Het
Gns C A 10: 121,207,095 (GRCm39) T72N probably damaging Het
Hspa2 T C 12: 76,452,542 (GRCm39) V412A probably damaging Het
Klk1b8 A G 7: 43,447,511 (GRCm39) I9V probably null Het
Map4 A G 9: 109,861,283 (GRCm39) T216A possibly damaging Het
Mid1-ps1 G A Y: 90,773,563 (GRCm39) noncoding transcript Het
Ndc1 G A 4: 107,268,269 (GRCm39) D602N probably benign Het
Nsd1 A G 13: 55,361,524 (GRCm39) D164G possibly damaging Het
Or5ac22 T A 16: 59,135,113 (GRCm39) H219L probably benign Het
Pcdha8 T C 18: 37,125,914 (GRCm39) M132T probably benign Het
Pomt2 A G 12: 87,158,296 (GRCm39) probably null Het
Prrt3 AGGGGG AGGGG 6: 113,474,641 (GRCm39) probably null Het
Rfx6 T A 10: 51,602,842 (GRCm39) H786Q probably damaging Het
Scn4a A C 11: 106,212,883 (GRCm39) L1374R possibly damaging Het
Slc16a9 C T 10: 70,110,786 (GRCm39) T124M probably damaging Het
Slc46a2 A T 4: 59,913,818 (GRCm39) F368L probably damaging Het
St18 T A 1: 6,898,010 (GRCm39) I604K probably damaging Het
Ttn A G 2: 76,548,497 (GRCm39) V31935A possibly damaging Het
Urb1 T C 16: 90,584,974 (GRCm39) H549R probably benign Het
Vmn1r219 A G 13: 23,347,272 (GRCm39) M154V probably benign Het
Zfp575 G A 7: 24,285,440 (GRCm39) S67L possibly damaging Het
Other mutations in Metrn
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0008:Metrn UTSW 17 26,015,479 (GRCm39) missense possibly damaging 0.94
R0280:Metrn UTSW 17 26,014,109 (GRCm39) missense probably benign 0.08
R0729:Metrn UTSW 17 26,015,202 (GRCm39) splice site probably benign
R1523:Metrn UTSW 17 26,013,951 (GRCm39) makesense probably null
R2119:Metrn UTSW 17 26,014,197 (GRCm39) missense probably benign 0.03
R2146:Metrn UTSW 17 26,015,601 (GRCm39) missense probably damaging 0.99
R4037:Metrn UTSW 17 26,013,984 (GRCm39) missense probably benign
R4038:Metrn UTSW 17 26,013,984 (GRCm39) missense probably benign
R4230:Metrn UTSW 17 26,015,915 (GRCm39) unclassified probably benign
R5074:Metrn UTSW 17 26,015,613 (GRCm39) missense probably damaging 1.00
R5259:Metrn UTSW 17 26,015,514 (GRCm39) missense probably damaging 1.00
R5686:Metrn UTSW 17 26,014,191 (GRCm39) missense probably damaging 1.00
R5744:Metrn UTSW 17 26,014,211 (GRCm39) missense probably damaging 1.00
R7707:Metrn UTSW 17 26,014,384 (GRCm39) missense probably benign 0.17
R8108:Metrn UTSW 17 26,014,004 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGAAGACCATGACTACAGTGGC -3'
(R):5'- ACACTGCCACTGTTCAAGG -3'

Sequencing Primer
(F):5'- ACCATGACTACAGTGGCTGGTATG -3'
(R):5'- CCACTGTTCAAGGAAGGGAGCTC -3'
Posted On 2015-04-30