Incidental Mutation 'R4038:Gpr83'
ID 313799
Institutional Source Beutler Lab
Gene Symbol Gpr83
Ensembl Gene ENSMUSG00000031932
Gene Name G protein-coupled receptor 83
Synonyms RP39, glucocorticoid-induced receptor, GIR, Gir, Gpr72, RP105, RP82
MMRRC Submission 040965-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R4038 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 14771506-14782085 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 14772073 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 82 (I82V)
Ref Sequence ENSEMBL: ENSMUSP00000111287 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034408] [ENSMUST00000115624]
AlphaFold P30731
Predicted Effect possibly damaging
Transcript: ENSMUST00000034408
AA Change: I82V

PolyPhen 2 Score 0.772 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000034408
Gene: ENSMUSG00000031932
AA Change: I82V

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:7tm_4 78 271 2.4e-8 PFAM
Pfam:7TM_GPCR_Srsx 82 360 6.6e-16 PFAM
Pfam:7tm_1 88 345 9e-52 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000115624
AA Change: I82V

PolyPhen 2 Score 0.772 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000111287
Gene: ENSMUSG00000031932
AA Change: I82V

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:7tm_1 88 133 1.1e-10 PFAM
Pfam:7TM_GPCR_Srsx 128 318 1.8e-6 PFAM
Pfam:7tm_1 129 303 1.4e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133278
Meta Mutation Damage Score 0.1910 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.1%
Validation Efficiency 93% (39/42)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal regulatory T cell development. Mice homozygous for a different targeted allele exhibit attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ate1 A G 7: 130,106,495 (GRCm39) S282P probably damaging Het
Cacna1d T A 14: 29,788,040 (GRCm39) Q1610L probably damaging Het
Carmil2 C A 8: 106,422,039 (GRCm39) R1103S probably damaging Het
Clca3a1 T A 3: 144,460,994 (GRCm39) Y219F probably benign Het
Creb3l3 A G 10: 80,925,172 (GRCm39) V224A probably benign Het
Crnkl1 T A 2: 145,774,247 (GRCm39) D72V possibly damaging Het
Dhcr24 T C 4: 106,431,075 (GRCm39) F255L probably benign Het
Eef2kmt A T 16: 5,063,135 (GRCm39) V335D probably damaging Het
Elp2 T A 18: 24,767,405 (GRCm39) W696R probably damaging Het
Glb1l3 A C 9: 26,740,343 (GRCm39) M329R probably damaging Het
Gm4787 A T 12: 81,425,132 (GRCm39) F342Y probably damaging Het
Gpr137c C A 14: 45,457,687 (GRCm39) L80I probably damaging Het
Greb1l C T 18: 10,515,209 (GRCm39) T558I possibly damaging Het
Hnrnpul2 T A 19: 8,800,591 (GRCm39) probably benign Het
Hspa2 T C 12: 76,452,542 (GRCm39) V412A probably damaging Het
Iqcd T C 5: 120,740,587 (GRCm39) V306A probably damaging Het
Lmod3 T C 6: 97,225,275 (GRCm39) N182S probably benign Het
Metrn T C 17: 26,013,984 (GRCm39) T281A probably benign Het
Mid1-ps1 G A Y: 90,773,563 (GRCm39) noncoding transcript Het
Mmachc T A 4: 116,563,215 (GRCm39) T47S probably damaging Het
Nfia C A 4: 97,909,074 (GRCm39) R277S probably damaging Het
Or9m2 T A 2: 87,821,262 (GRCm39) I269N possibly damaging Het
Pcdha8 T C 18: 37,125,914 (GRCm39) M132T probably benign Het
Prkaa2 T C 4: 104,908,444 (GRCm39) N144D probably damaging Het
Ptprf C T 4: 118,114,805 (GRCm39) R150H probably damaging Het
Sfmbt1 T G 14: 30,509,449 (GRCm39) D309E probably damaging Het
Skint5 G T 4: 113,743,011 (GRCm39) T352K unknown Het
Slc16a10 G C 10: 39,932,620 (GRCm39) H314D possibly damaging Het
Slc28a2 C A 2: 122,284,996 (GRCm39) A328E probably benign Het
Ssc4d C A 5: 135,999,170 (GRCm39) W11L possibly damaging Het
Sycp2 C A 2: 178,022,720 (GRCm39) M470I possibly damaging Het
Tfap2c A T 2: 172,398,110 (GRCm39) S413C probably damaging Het
Unc13c A G 9: 73,441,188 (GRCm39) probably null Het
Vmn1r218 T C 13: 23,320,971 (GRCm39) V26A possibly damaging Het
Wipf3 G A 6: 54,458,813 (GRCm39) G56D probably damaging Het
Wiz T C 17: 32,578,198 (GRCm39) E429G probably damaging Het
Zer1 T C 2: 29,997,535 (GRCm39) N457S probably damaging Het
Zfp931 T A 2: 177,709,777 (GRCm39) Q203L possibly damaging Het
Other mutations in Gpr83
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00579:Gpr83 APN 9 14,771,897 (GRCm39) missense probably benign 0.00
bland UTSW 9 14,778,279 (GRCm39) critical splice donor site probably null
R0243:Gpr83 UTSW 9 14,776,138 (GRCm39) missense possibly damaging 0.96
R0349:Gpr83 UTSW 9 14,779,563 (GRCm39) missense probably damaging 1.00
R0731:Gpr83 UTSW 9 14,779,940 (GRCm39) missense probably benign 0.00
R1519:Gpr83 UTSW 9 14,779,493 (GRCm39) missense probably null 1.00
R1678:Gpr83 UTSW 9 14,778,145 (GRCm39) missense probably damaging 1.00
R1826:Gpr83 UTSW 9 14,779,629 (GRCm39) missense possibly damaging 0.53
R1827:Gpr83 UTSW 9 14,779,629 (GRCm39) missense possibly damaging 0.53
R1828:Gpr83 UTSW 9 14,779,629 (GRCm39) missense possibly damaging 0.53
R2938:Gpr83 UTSW 9 14,776,167 (GRCm39) missense probably benign 0.23
R3760:Gpr83 UTSW 9 14,772,034 (GRCm39) missense probably benign 0.03
R4438:Gpr83 UTSW 9 14,776,134 (GRCm39) missense probably damaging 0.99
R4657:Gpr83 UTSW 9 14,778,279 (GRCm39) critical splice donor site probably null
R4731:Gpr83 UTSW 9 14,777,470 (GRCm39) intron probably benign
R5150:Gpr83 UTSW 9 14,772,101 (GRCm39) missense probably damaging 1.00
R7770:Gpr83 UTSW 9 14,778,170 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGCTGGACATGAAGGTTCC -3'
(R):5'- TTCAGGAGAAGAGACAGCCC -3'

Sequencing Primer
(F):5'- TCCTCAGTGCGAGCTACTGAG -3'
(R):5'- AAGAGACAGCCCGGGAG -3'
Posted On 2015-04-30