Incidental Mutation 'R4051:Itga11'
ID 314166
Institutional Source Beutler Lab
Gene Symbol Itga11
Ensembl Gene ENSMUSG00000032243
Gene Name integrin alpha 11
Synonyms 4732459H24Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R4051 ()
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 62585108-62691264 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 62662933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 550 (Q550*)
Ref Sequence ENSEMBL: ENSMUSP00000034774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034774]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000034774
AA Change: Q550*
SMART Domains Protein: ENSMUSP00000034774
Gene: ENSMUSG00000032243
AA Change: Q550*

DomainStartEndE-ValueType
Int_alpha 37 90 3.9e-7 SMART
VWA 162 350 2.74e-38 SMART
Int_alpha 421 472 2.19e-1 SMART
Int_alpha 476 532 3.75e-9 SMART
Int_alpha 538 593 1.39e-12 SMART
Int_alpha 600 654 1.08e0 SMART
transmembrane domain 1142 1164 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159012
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption of this gene display dwarfism, increased mortality with age, and defective incisors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A C 7: 45,635,987 (GRCm39) L1020R probably damaging Het
Ahnak A C 19: 8,991,691 (GRCm39) D4325A probably damaging Het
Chtf18 A G 17: 25,938,168 (GRCm39) V955A probably damaging Het
Dclk2 A G 3: 86,738,129 (GRCm39) probably null Het
Disc1 A G 8: 125,875,164 (GRCm39) T547A possibly damaging Het
Eif4b A G 15: 101,995,039 (GRCm39) Y211C probably benign Het
Fli1 T G 9: 32,363,458 (GRCm39) D176A probably benign Het
Hcn2 A C 10: 79,569,521 (GRCm39) probably null Het
Ice1 A G 13: 70,751,646 (GRCm39) V1480A probably damaging Het
Ier5l A C 2: 30,363,324 (GRCm39) S234A probably benign Het
Ino80b G C 6: 83,099,314 (GRCm39) P178R probably damaging Het
Kdr T A 5: 76,129,068 (GRCm39) M193L probably benign Het
Kif3b G A 2: 153,165,477 (GRCm39) R628Q probably damaging Het
Ldlrad3 C T 2: 101,783,507 (GRCm39) D240N probably damaging Het
Met T C 6: 17,548,728 (GRCm39) V924A possibly damaging Het
Or52m1 T C 7: 102,290,233 (GRCm39) V260A possibly damaging Het
Peg10 T C 6: 4,754,534 (GRCm39) L105P probably benign Het
Phtf1 A G 3: 103,912,824 (GRCm39) T717A possibly damaging Het
Ptafr T C 4: 132,307,305 (GRCm39) W232R probably benign Het
Rnase4 A G 14: 51,342,462 (GRCm39) K62R probably benign Het
Slamf7 T C 1: 171,464,951 (GRCm39) K261E possibly damaging Het
Slc9c1 T A 16: 45,363,593 (GRCm39) Y120N probably damaging Het
Sstr2 A C 11: 113,515,482 (GRCm39) T134P probably damaging Het
Steap4 A G 5: 8,030,404 (GRCm39) Y420C probably damaging Het
Tbc1d9b T C 11: 50,062,070 (GRCm39) C1210R probably benign Het
Tnfsf10 T A 3: 27,389,503 (GRCm39) I188N probably damaging Het
Trav7-3 A G 14: 53,681,203 (GRCm39) T82A probably benign Het
Usp46 T C 5: 74,163,416 (GRCm39) N283S probably benign Het
Vmn2r84 T G 10: 130,226,767 (GRCm39) N357T probably damaging Het
Zfp217 T C 2: 169,954,536 (GRCm39) probably null Het
Other mutations in Itga11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00933:Itga11 APN 9 62,676,587 (GRCm39) missense possibly damaging 0.58
IGL01108:Itga11 APN 9 62,664,903 (GRCm39) missense probably benign
IGL01348:Itga11 APN 9 62,651,861 (GRCm39) missense possibly damaging 0.83
IGL01739:Itga11 APN 9 62,681,399 (GRCm39) missense probably benign 0.03
IGL01918:Itga11 APN 9 62,680,278 (GRCm39) missense probably benign 0.05
IGL02237:Itga11 APN 9 62,663,057 (GRCm39) critical splice donor site probably null
IGL02418:Itga11 APN 9 62,651,914 (GRCm39) missense probably benign 0.30
IGL02451:Itga11 APN 9 62,642,635 (GRCm39) missense probably damaging 1.00
sneezy UTSW 9 62,639,391 (GRCm39) missense probably damaging 1.00
PIT4812001:Itga11 UTSW 9 62,639,475 (GRCm39) missense probably damaging 1.00
R0013:Itga11 UTSW 9 62,683,895 (GRCm39) missense possibly damaging 0.89
R0013:Itga11 UTSW 9 62,683,895 (GRCm39) missense possibly damaging 0.89
R0032:Itga11 UTSW 9 62,681,377 (GRCm39) missense probably benign 0.05
R0032:Itga11 UTSW 9 62,681,377 (GRCm39) missense probably benign 0.05
R0101:Itga11 UTSW 9 62,651,768 (GRCm39) missense probably damaging 1.00
R0114:Itga11 UTSW 9 62,667,584 (GRCm39) missense possibly damaging 0.85
R0114:Itga11 UTSW 9 62,642,575 (GRCm39) missense probably damaging 1.00
R0212:Itga11 UTSW 9 62,653,251 (GRCm39) missense probably benign 0.22
R0310:Itga11 UTSW 9 62,667,628 (GRCm39) missense probably damaging 1.00
R0455:Itga11 UTSW 9 62,604,243 (GRCm39) missense probably damaging 1.00
R0558:Itga11 UTSW 9 62,659,570 (GRCm39) missense probably benign 0.01
R0607:Itga11 UTSW 9 62,681,653 (GRCm39) missense probably benign 0.00
R0924:Itga11 UTSW 9 62,683,956 (GRCm39) missense probably benign 0.14
R1085:Itga11 UTSW 9 62,585,252 (GRCm39) missense probably benign 0.03
R1477:Itga11 UTSW 9 62,662,493 (GRCm39) missense probably benign
R1647:Itga11 UTSW 9 62,667,652 (GRCm39) missense probably benign 0.01
R1831:Itga11 UTSW 9 62,689,300 (GRCm39) missense probably damaging 1.00
R1880:Itga11 UTSW 9 62,585,231 (GRCm39) missense probably benign 0.06
R1934:Itga11 UTSW 9 62,651,796 (GRCm39) missense probably damaging 1.00
R2025:Itga11 UTSW 9 62,670,093 (GRCm39) missense probably damaging 1.00
R2046:Itga11 UTSW 9 62,634,979 (GRCm39) missense probably damaging 1.00
R2145:Itga11 UTSW 9 62,639,486 (GRCm39) splice site probably benign
R2922:Itga11 UTSW 9 62,675,912 (GRCm39) splice site probably benign
R3011:Itga11 UTSW 9 62,604,262 (GRCm39) missense probably damaging 0.99
R3158:Itga11 UTSW 9 62,676,560 (GRCm39) missense probably benign 0.02
R3809:Itga11 UTSW 9 62,678,664 (GRCm39) missense probably benign
R3836:Itga11 UTSW 9 62,676,565 (GRCm39) missense probably benign 0.00
R4190:Itga11 UTSW 9 62,639,391 (GRCm39) missense probably damaging 1.00
R4510:Itga11 UTSW 9 62,668,870 (GRCm39) missense probably damaging 0.96
R4511:Itga11 UTSW 9 62,668,870 (GRCm39) missense probably damaging 0.96
R4678:Itga11 UTSW 9 62,642,639 (GRCm39) missense probably damaging 0.98
R4706:Itga11 UTSW 9 62,662,578 (GRCm39) missense possibly damaging 0.64
R4713:Itga11 UTSW 9 62,673,070 (GRCm39) missense probably damaging 1.00
R4798:Itga11 UTSW 9 62,684,009 (GRCm39) splice site probably null
R4909:Itga11 UTSW 9 62,662,581 (GRCm39) missense probably damaging 1.00
R4915:Itga11 UTSW 9 62,659,530 (GRCm39) nonsense probably null
R4957:Itga11 UTSW 9 62,674,930 (GRCm39) missense probably benign 0.00
R4962:Itga11 UTSW 9 62,668,850 (GRCm39) nonsense probably null
R5081:Itga11 UTSW 9 62,662,478 (GRCm39) missense probably benign 0.13
R5265:Itga11 UTSW 9 62,644,694 (GRCm39) missense probably benign 0.05
R5308:Itga11 UTSW 9 62,663,051 (GRCm39) missense probably benign
R5398:Itga11 UTSW 9 62,653,205 (GRCm39) missense probably benign 0.21
R5717:Itga11 UTSW 9 62,659,531 (GRCm39) missense probably benign 0.26
R5885:Itga11 UTSW 9 62,670,132 (GRCm39) missense probably damaging 0.99
R5996:Itga11 UTSW 9 62,662,955 (GRCm39) missense probably benign 0.01
R6394:Itga11 UTSW 9 62,642,548 (GRCm39) splice site probably null
R6751:Itga11 UTSW 9 62,675,866 (GRCm39) missense probably benign 0.02
R7041:Itga11 UTSW 9 62,659,538 (GRCm39) missense probably damaging 1.00
R7264:Itga11 UTSW 9 62,653,190 (GRCm39) missense probably benign 0.02
R7509:Itga11 UTSW 9 62,689,222 (GRCm39) missense probably benign
R7601:Itga11 UTSW 9 62,604,208 (GRCm39) missense probably benign 0.18
R7615:Itga11 UTSW 9 62,651,300 (GRCm39) missense probably benign 0.00
R8263:Itga11 UTSW 9 62,604,262 (GRCm39) missense possibly damaging 0.86
R8285:Itga11 UTSW 9 62,659,540 (GRCm39) missense probably damaging 1.00
R8419:Itga11 UTSW 9 62,662,460 (GRCm39) missense possibly damaging 0.59
R8422:Itga11 UTSW 9 62,674,960 (GRCm39) missense probably benign 0.00
R8469:Itga11 UTSW 9 62,678,680 (GRCm39) missense probably benign 0.00
R8475:Itga11 UTSW 9 62,651,327 (GRCm39) missense probably damaging 1.00
R8871:Itga11 UTSW 9 62,668,823 (GRCm39) nonsense probably null
R8904:Itga11 UTSW 9 62,664,893 (GRCm39) missense probably benign
R8954:Itga11 UTSW 9 62,676,545 (GRCm39) missense possibly damaging 0.58
R8977:Itga11 UTSW 9 62,662,922 (GRCm39) missense probably damaging 0.98
R9011:Itga11 UTSW 9 62,662,909 (GRCm39) missense probably benign 0.43
R9038:Itga11 UTSW 9 62,675,039 (GRCm39) missense possibly damaging 0.90
R9089:Itga11 UTSW 9 62,678,662 (GRCm39) missense probably damaging 1.00
R9262:Itga11 UTSW 9 62,659,678 (GRCm39) splice site probably benign
R9327:Itga11 UTSW 9 62,638,034 (GRCm39) missense probably damaging 1.00
R9487:Itga11 UTSW 9 62,670,171 (GRCm39) missense probably benign 0.35
R9794:Itga11 UTSW 9 62,662,868 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTATCTGGGCTCCTGTCATC -3'
(R):5'- TTCCTGTAGGAGGCCATGAC -3'

Sequencing Primer
(F):5'- CATCAGGATGGGTTCTGGAAG -3'
(R):5'- ACAGGAGTTCATGGGCGCTG -3'
Posted On 2015-04-30