Incidental Mutation 'R4051:Eif4b'
ID 314177
Institutional Source Beutler Lab
Gene Symbol Eif4b
Ensembl Gene ENSMUSG00000058655
Gene Name eukaryotic translation initiation factor 4B
Synonyms 2310046H11Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R4051 ()
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 101982208-102005608 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 101995039 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 211 (Y211C)
Ref Sequence ENSEMBL: ENSMUSP00000127774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169681] [ENSMUST00000229400]
AlphaFold Q8BGD9
Predicted Effect probably benign
Transcript: ENSMUST00000169681
AA Change: Y211C

PolyPhen 2 Score 0.307 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000127774
Gene: ENSMUSG00000058655
AA Change: Y211C

DomainStartEndE-ValueType
low complexity region 6 13 N/A INTRINSIC
RRM 97 169 1.54e-15 SMART
low complexity region 221 273 N/A INTRINSIC
low complexity region 282 327 N/A INTRINSIC
low complexity region 347 359 N/A INTRINSIC
low complexity region 372 391 N/A INTRINSIC
low complexity region 408 428 N/A INTRINSIC
low complexity region 574 581 N/A INTRINSIC
low complexity region 584 597 N/A INTRINSIC
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229122
Predicted Effect unknown
Transcript: ENSMUST00000229400
AA Change: Y211C
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A C 7: 45,635,987 (GRCm39) L1020R probably damaging Het
Ahnak A C 19: 8,991,691 (GRCm39) D4325A probably damaging Het
Chtf18 A G 17: 25,938,168 (GRCm39) V955A probably damaging Het
Dclk2 A G 3: 86,738,129 (GRCm39) probably null Het
Disc1 A G 8: 125,875,164 (GRCm39) T547A possibly damaging Het
Fli1 T G 9: 32,363,458 (GRCm39) D176A probably benign Het
Hcn2 A C 10: 79,569,521 (GRCm39) probably null Het
Ice1 A G 13: 70,751,646 (GRCm39) V1480A probably damaging Het
Ier5l A C 2: 30,363,324 (GRCm39) S234A probably benign Het
Ino80b G C 6: 83,099,314 (GRCm39) P178R probably damaging Het
Itga11 C T 9: 62,662,933 (GRCm39) Q550* probably null Het
Kdr T A 5: 76,129,068 (GRCm39) M193L probably benign Het
Kif3b G A 2: 153,165,477 (GRCm39) R628Q probably damaging Het
Ldlrad3 C T 2: 101,783,507 (GRCm39) D240N probably damaging Het
Met T C 6: 17,548,728 (GRCm39) V924A possibly damaging Het
Or52m1 T C 7: 102,290,233 (GRCm39) V260A possibly damaging Het
Peg10 T C 6: 4,754,534 (GRCm39) L105P probably benign Het
Phtf1 A G 3: 103,912,824 (GRCm39) T717A possibly damaging Het
Ptafr T C 4: 132,307,305 (GRCm39) W232R probably benign Het
Rnase4 A G 14: 51,342,462 (GRCm39) K62R probably benign Het
Slamf7 T C 1: 171,464,951 (GRCm39) K261E possibly damaging Het
Slc9c1 T A 16: 45,363,593 (GRCm39) Y120N probably damaging Het
Sstr2 A C 11: 113,515,482 (GRCm39) T134P probably damaging Het
Steap4 A G 5: 8,030,404 (GRCm39) Y420C probably damaging Het
Tbc1d9b T C 11: 50,062,070 (GRCm39) C1210R probably benign Het
Tnfsf10 T A 3: 27,389,503 (GRCm39) I188N probably damaging Het
Trav7-3 A G 14: 53,681,203 (GRCm39) T82A probably benign Het
Usp46 T C 5: 74,163,416 (GRCm39) N283S probably benign Het
Vmn2r84 T G 10: 130,226,767 (GRCm39) N357T probably damaging Het
Zfp217 T C 2: 169,954,536 (GRCm39) probably null Het
Other mutations in Eif4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Eif4b APN 15 101,999,858 (GRCm39) missense probably benign 0.23
IGL01896:Eif4b APN 15 102,003,721 (GRCm39) missense probably benign 0.23
IGL03348:Eif4b APN 15 102,001,466 (GRCm39) unclassified probably benign
R1577:Eif4b UTSW 15 101,998,336 (GRCm39) nonsense probably null
R1727:Eif4b UTSW 15 101,998,497 (GRCm39) missense possibly damaging 0.71
R1931:Eif4b UTSW 15 101,997,411 (GRCm39) missense unknown
R3927:Eif4b UTSW 15 101,992,745 (GRCm39) missense probably damaging 1.00
R4392:Eif4b UTSW 15 101,995,076 (GRCm39) critical splice donor site probably null
R5105:Eif4b UTSW 15 101,992,631 (GRCm39) missense probably benign 0.42
R5716:Eif4b UTSW 15 101,990,494 (GRCm39) missense probably benign 0.36
R6488:Eif4b UTSW 15 102,001,422 (GRCm39) unclassified probably benign
R7048:Eif4b UTSW 15 102,001,571 (GRCm39) unclassified probably benign
R7647:Eif4b UTSW 15 101,997,129 (GRCm39) missense unknown
R7648:Eif4b UTSW 15 101,997,435 (GRCm39) missense unknown
R8145:Eif4b UTSW 15 102,001,423 (GRCm39) missense unknown
R8709:Eif4b UTSW 15 102,002,116 (GRCm39) missense unknown
R9079:Eif4b UTSW 15 102,003,177 (GRCm39) missense unknown
R9298:Eif4b UTSW 15 101,990,449 (GRCm39) missense possibly damaging 0.72
R9716:Eif4b UTSW 15 101,990,443 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- GCCAGTGCAATAGAAACCGTAG -3'
(R):5'- TGTGTTCAAAGAGAAATGCCTG -3'

Sequencing Primer
(F):5'- TAGGTGGGATGTGAGGGACC -3'
(R):5'- CAAAGAGAAATGCCTGTACTTTCTG -3'
Posted On 2015-04-30