Incidental Mutation 'R4058:Taok1'
ID 314353
Institutional Source Beutler Lab
Gene Symbol Taok1
Ensembl Gene ENSMUSG00000017291
Gene Name TAO kinase 1
Synonyms 2810468K05Rik, D130018F14Rik
MMRRC Submission 040969-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.455) question?
Stock # R4058 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 77419988-77498641 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 77440264 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 581 (K581M)
Ref Sequence ENSEMBL: ENSMUSP00000055470 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017435] [ENSMUST00000058496]
AlphaFold Q5F2E8
Predicted Effect probably benign
Transcript: ENSMUST00000017435
AA Change: K581M

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000017435
Gene: ENSMUSG00000017291
AA Change: K581M

DomainStartEndE-ValueType
S_TKc 28 281 3.26e-87 SMART
low complexity region 327 335 N/A INTRINSIC
low complexity region 350 370 N/A INTRINSIC
coiled coil region 458 651 N/A INTRINSIC
coiled coil region 792 878 N/A INTRINSIC
low complexity region 914 930 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000058496
AA Change: K581M

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000055470
Gene: ENSMUSG00000017291
AA Change: K581M

DomainStartEndE-ValueType
S_TKc 28 281 3.26e-87 SMART
low complexity region 327 335 N/A INTRINSIC
low complexity region 350 370 N/A INTRINSIC
coiled coil region 458 651 N/A INTRINSIC
coiled coil region 792 878 N/A INTRINSIC
low complexity region 914 930 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 88% (38/43)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930453N24Rik A G 16: 64,586,821 (GRCm39) V301A probably benign Het
Adam15 A G 3: 89,254,362 (GRCm39) V145A possibly damaging Het
Anxa4 C T 6: 86,734,800 (GRCm39) probably null Het
Aqp9 C A 9: 71,037,726 (GRCm39) V184L probably benign Het
Atp13a3 C A 16: 30,173,064 (GRCm39) C271F possibly damaging Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Cldn34c4 C A X: 126,629,060 (GRCm39) V137F probably benign Het
Cngb1 T C 8: 95,994,282 (GRCm39) E163G probably benign Het
Dync1i1 A G 6: 5,769,764 (GRCm39) D113G probably damaging Het
Etl4 T A 2: 20,810,830 (GRCm39) V971D possibly damaging Het
Gys1 A G 7: 45,097,810 (GRCm39) probably benign Het
H13 C G 2: 152,533,794 (GRCm39) P227R probably damaging Het
Ift22 C A 5: 136,940,717 (GRCm39) P84Q unknown Het
Igfn1 A G 1: 135,897,494 (GRCm39) V1024A probably benign Het
Kdm8 T A 7: 125,055,666 (GRCm39) Y65N probably damaging Het
Lbp T A 2: 158,166,550 (GRCm39) V368E probably damaging Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Megf6 T C 4: 154,326,989 (GRCm39) probably benign Het
Mettl13 G T 1: 162,373,755 (GRCm39) H165Q probably damaging Het
Mitd1 C T 1: 37,920,107 (GRCm39) S167N probably benign Het
Mon2 A G 10: 122,838,724 (GRCm39) V1593A probably benign Het
Nkx3-2 T A 5: 41,919,406 (GRCm39) E194V possibly damaging Het
Nup210 A T 6: 91,037,602 (GRCm39) V757D probably benign Het
Opcml A G 9: 28,812,884 (GRCm39) Y192C probably damaging Het
Or10ak7 T C 4: 118,791,880 (GRCm39) D53G probably damaging Het
Or5m8 T A 2: 85,822,576 (GRCm39) S138R possibly damaging Het
Pcdha2 A G 18: 37,072,935 (GRCm39) S189G probably benign Het
Pkd2l2 T C 18: 34,561,245 (GRCm39) F418L probably benign Het
Plekhg1 A G 10: 3,907,087 (GRCm39) D668G probably damaging Het
Prep G A 10: 45,034,467 (GRCm39) V660M probably benign Het
Qrfprl T A 6: 65,358,525 (GRCm39) I83N probably damaging Het
Rgs8 A G 1: 153,566,742 (GRCm39) T98A probably null Het
Rhbdd1 A G 1: 82,348,102 (GRCm39) N235D possibly damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Sgo2b A T 8: 64,379,981 (GRCm39) D950E probably damaging Het
Slc1a5 T C 7: 16,529,778 (GRCm39) V399A probably damaging Het
Spag16 A T 1: 69,892,487 (GRCm39) Q89H probably damaging Het
Spta1 T C 1: 174,068,703 (GRCm39) W2168R probably damaging Het
Tns3 T C 11: 8,442,275 (GRCm39) D696G probably damaging Het
Tspan8 C T 10: 115,671,187 (GRCm39) R115* probably null Het
Txnrd1 A G 10: 82,721,114 (GRCm39) E510G probably benign Het
Usp45 T C 4: 21,810,746 (GRCm39) I314T probably damaging Het
Vmn2r15 T A 5: 109,441,312 (GRCm39) H182L probably damaging Het
Vmn2r76 A C 7: 85,879,508 (GRCm39) M264R probably benign Het
Other mutations in Taok1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01598:Taok1 APN 11 77,462,510 (GRCm39) missense probably damaging 1.00
IGL01629:Taok1 APN 11 77,429,030 (GRCm39) missense possibly damaging 0.63
IGL02198:Taok1 APN 11 77,466,503 (GRCm39) splice site probably benign
IGL02392:Taok1 APN 11 77,440,178 (GRCm39) missense probably benign 0.13
IGL02415:Taok1 APN 11 77,431,066 (GRCm39) unclassified probably benign
IGL02428:Taok1 APN 11 77,440,103 (GRCm39) missense probably benign 0.01
IGL02972:Taok1 APN 11 77,450,584 (GRCm39) missense probably benign 0.04
IGL03200:Taok1 APN 11 77,466,478 (GRCm39) nonsense probably null
IGL03203:Taok1 APN 11 77,430,911 (GRCm39) missense probably damaging 0.96
IGL03292:Taok1 APN 11 77,430,962 (GRCm39) missense probably benign 0.07
IGL03351:Taok1 APN 11 77,451,154 (GRCm39) missense probably damaging 0.96
R7569_taok1_653 UTSW 11 77,446,440 (GRCm39) missense probably benign 0.06
R0070:Taok1 UTSW 11 77,444,543 (GRCm39) missense probably benign
R0497:Taok1 UTSW 11 77,464,630 (GRCm39) missense probably damaging 0.97
R0535:Taok1 UTSW 11 77,444,530 (GRCm39) missense probably benign 0.00
R0558:Taok1 UTSW 11 77,450,670 (GRCm39) missense possibly damaging 0.89
R0653:Taok1 UTSW 11 77,469,550 (GRCm39) critical splice donor site probably null
R1249:Taok1 UTSW 11 77,462,463 (GRCm39) missense probably damaging 1.00
R1424:Taok1 UTSW 11 77,440,190 (GRCm39) missense probably benign 0.00
R1597:Taok1 UTSW 11 77,470,626 (GRCm39) missense probably benign 0.31
R2112:Taok1 UTSW 11 77,462,472 (GRCm39) missense probably benign 0.01
R3716:Taok1 UTSW 11 77,432,636 (GRCm39) missense probably benign 0.09
R4013:Taok1 UTSW 11 77,450,659 (GRCm39) missense possibly damaging 0.95
R4831:Taok1 UTSW 11 77,444,500 (GRCm39) missense probably null 0.34
R5036:Taok1 UTSW 11 77,440,157 (GRCm39) missense probably benign 0.01
R5917:Taok1 UTSW 11 77,451,144 (GRCm39) missense probably damaging 0.99
R6271:Taok1 UTSW 11 77,464,609 (GRCm39) missense probably damaging 1.00
R6286:Taok1 UTSW 11 77,444,599 (GRCm39) missense probably benign 0.00
R6860:Taok1 UTSW 11 77,432,627 (GRCm39) missense probably benign 0.01
R6933:Taok1 UTSW 11 77,446,479 (GRCm39) missense probably benign
R7139:Taok1 UTSW 11 77,462,459 (GRCm39) missense probably damaging 1.00
R7143:Taok1 UTSW 11 77,428,814 (GRCm39) missense probably benign
R7305:Taok1 UTSW 11 77,432,500 (GRCm39) nonsense probably null
R7340:Taok1 UTSW 11 77,470,643 (GRCm39) missense possibly damaging 0.89
R7508:Taok1 UTSW 11 77,436,152 (GRCm39) missense probably damaging 0.97
R7569:Taok1 UTSW 11 77,446,440 (GRCm39) missense probably benign 0.06
R7753:Taok1 UTSW 11 77,428,725 (GRCm39) missense probably benign 0.29
R8064:Taok1 UTSW 11 77,440,130 (GRCm39) nonsense probably null
R8130:Taok1 UTSW 11 77,470,659 (GRCm39) missense possibly damaging 0.84
R8332:Taok1 UTSW 11 77,432,545 (GRCm39) missense possibly damaging 0.93
R8768:Taok1 UTSW 11 77,444,712 (GRCm39) missense probably damaging 1.00
R8775:Taok1 UTSW 11 77,470,632 (GRCm39) missense probably benign 0.42
R8775-TAIL:Taok1 UTSW 11 77,470,632 (GRCm39) missense probably benign 0.42
Z1176:Taok1 UTSW 11 77,450,752 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TACAGAGTAAGGCATTGCTGAAAAC -3'
(R):5'- TGGTCTTTTAAAGCCAGGAACTATG -3'

Sequencing Primer
(F):5'- CATTTAAATGTACATACCTCCCTGAC -3'
(R):5'- GCCAGGAACTATGAAAATTAAATTGC -3'
Posted On 2015-04-30