Incidental Mutation 'R4112:Klf17'
ID 314450
Institutional Source Beutler Lab
Gene Symbol Klf17
Ensembl Gene ENSMUSG00000048626
Gene Name Kruppel-like factor 17
Synonyms D4Ertd561e, 7420700M05Rik, Zfp393
MMRRC Submission 040989-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # R4112 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 117757836-117765648 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117760701 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 153 (V153A)
Ref Sequence ENSEMBL: ENSMUSP00000052316 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062747]
AlphaFold Q8CFA7
Predicted Effect possibly damaging
Transcript: ENSMUST00000062747
AA Change: V153A

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000052316
Gene: ENSMUSG00000048626
AA Change: V153A

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 142 157 N/A INTRINSIC
low complexity region 202 213 N/A INTRINSIC
ZnF_C2H2 256 280 4.47e-3 SMART
ZnF_C2H2 286 310 1.92e-2 SMART
ZnF_C2H2 316 338 1.1e-2 SMART
Meta Mutation Damage Score 0.0835 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.3%
Validation Efficiency 97% (56/58)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,794,154 C172* probably null Het
5830411N06Rik G T 7: 140,298,368 G1003* probably null Het
Aamp A G 1: 74,281,227 probably benign Het
Abcb4 A G 5: 8,936,783 probably null Het
Adam6b T A 12: 113,489,636 F24L possibly damaging Het
Alms1 G A 6: 85,620,888 V1368I probably benign Het
Angpt2 T A 8: 18,699,123 Q326L probably damaging Het
Armc9 T A 1: 86,188,939 I327N possibly damaging Het
Bace2 A G 16: 97,436,656 T436A probably benign Het
Ccdc162 T A 10: 41,656,328 E450V possibly damaging Het
Ccdc7b G T 8: 129,085,227 probably benign Het
Cdh17 T C 4: 11,814,628 S728P probably damaging Het
Chia1 T C 3: 106,128,528 L168P probably damaging Het
Cnot1 A C 8: 95,773,618 L111V probably damaging Het
Col14a1 A T 15: 55,363,559 N235I unknown Het
Col2a1 A C 15: 97,983,701 L787R probably benign Het
Cyp3a25 A T 5: 146,003,031 D55E probably benign Het
Dennd6a A T 14: 26,628,518 probably benign Het
Dnajc28 G A 16: 91,616,867 T187M probably damaging Het
Etfbkmt T C 6: 149,144,591 probably benign Het
Etfrf1 T C 6: 145,215,372 Y23H probably damaging Het
Gemin4 T A 11: 76,212,819 E372V probably damaging Het
Glyr1 T C 16: 5,018,486 K500E possibly damaging Het
Gm10271 A T 10: 116,968,038 probably benign Het
Gm20775 A T Y: 10,641,878 noncoding transcript Het
Gm5578 A G 6: 112,606,505 noncoding transcript Het
Gxylt2 A G 6: 100,783,206 N234S probably damaging Het
Kcna6 G C 6: 126,739,774 R51G probably damaging Het
L3mbtl2 T C 15: 81,681,969 V331A possibly damaging Het
Med1 A T 11: 98,180,087 V110E probably damaging Het
Nsmaf A C 4: 6,417,188 Y535* probably null Het
Pcdh10 G A 3: 45,381,620 V790M probably damaging Het
Phlpp1 A G 1: 106,364,338 T976A probably damaging Het
Prelid3a T C 18: 67,472,897 Y25H probably damaging Het
Ptprk T A 10: 28,475,288 probably null Het
Rbm5 A T 9: 107,765,597 D79E probably damaging Het
Rhox3f G T X: 37,582,019 E140* probably null Het
Rnd3 T A 2: 51,148,230 T78S possibly damaging Het
Sgca T C 11: 94,972,570 T27A possibly damaging Het
Slc10a2 C T 8: 5,105,135 D17N probably benign Het
Snap23 C T 2: 120,584,375 probably benign Het
Sptb T A 12: 76,597,779 T2098S probably damaging Het
Src T A 2: 157,463,026 L165H probably damaging Het
Srr G T 11: 74,913,072 Q20K probably benign Het
Stt3b A T 9: 115,266,138 F275Y probably damaging Het
Sucnr1 C G 3: 60,086,794 R248G probably damaging Het
Thsd7b A T 1: 130,116,619 D1112V probably benign Het
Tmem80 A G 7: 141,333,779 probably benign Het
Top2a C A 11: 99,022,960 K18N probably damaging Het
Ttc24 T A 3: 88,074,639 D40V probably damaging Het
Vmn2r-ps159 G T 4: 156,334,397 noncoding transcript Het
Zfp3 T A 11: 70,771,507 S97R probably benign Het
Other mutations in Klf17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Klf17 APN 4 117761038 missense probably benign 0.06
IGL01399:Klf17 APN 4 117759159 missense probably damaging 1.00
R0047:Klf17 UTSW 4 117761032 missense probably benign 0.00
R0051:Klf17 UTSW 4 117760392 missense probably damaging 1.00
R0051:Klf17 UTSW 4 117760392 missense probably damaging 1.00
R1513:Klf17 UTSW 4 117760935 missense probably damaging 0.96
R3103:Klf17 UTSW 4 117760608 missense possibly damaging 0.72
R4180:Klf17 UTSW 4 117759186 missense probably benign 0.14
R4669:Klf17 UTSW 4 117760371 missense probably damaging 1.00
R4715:Klf17 UTSW 4 117760536 missense probably benign 0.44
R5063:Klf17 UTSW 4 117760659 missense possibly damaging 0.85
R7578:Klf17 UTSW 4 117760719 missense possibly damaging 0.85
R7765:Klf17 UTSW 4 117760615 missense probably benign 0.08
R9041:Klf17 UTSW 4 117760359 missense probably damaging 1.00
Z1176:Klf17 UTSW 4 117760351 missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TGAATCTTGGGAGTCTAAAGGTAGC -3'
(R):5'- TCATTAGGTCGCTGCCTGAG -3'

Sequencing Primer
(F):5'- GCAATTGCTGGAACCTAGCTG -3'
(R):5'- AGAATTATTGTCAGAGATCGATTGGG -3'
Posted On 2015-05-14