Incidental Mutation 'R4113:Or14a258'
ID 314501
Institutional Source Beutler Lab
Gene Symbol Or14a258
Ensembl Gene ENSMUSG00000062426
Gene Name olfactory receptor family 14 subfamily A member 258
Synonyms GA_x6K02T2NHDJ-9721756-9722757, MOR219-3P, Olfr304
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R4113 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 86034865-86035866 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 86035733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 45 (T45M)
Ref Sequence ENSEMBL: ENSMUSP00000076449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077210]
AlphaFold Q7TS03
Predicted Effect possibly damaging
Transcript: ENSMUST00000077210
AA Change: T45M

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000076449
Gene: ENSMUSG00000062426
AA Change: T45M

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 8.9e-38 PFAM
Pfam:7tm_1 39 288 1.1e-21 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bace2 A G 16: 97,237,856 (GRCm39) T436A probably benign Het
BC024139 A G 15: 76,005,827 (GRCm39) M458T probably benign Het
Casp2 G A 6: 42,244,828 (GRCm39) A76T probably damaging Het
Catsper3 A G 13: 55,934,183 (GRCm39) K35E probably damaging Het
Ccdc88c A G 12: 100,911,332 (GRCm39) L34P probably damaging Het
Dcaf13 T A 15: 38,993,615 (GRCm39) I236N probably damaging Het
Dip2c G T 13: 9,687,137 (GRCm39) G1254C probably damaging Het
Dnah12 T C 14: 26,414,722 (GRCm39) L41P probably damaging Het
Dnah17 T C 11: 118,003,420 (GRCm39) K514R possibly damaging Het
Dnajb12 T A 10: 59,730,136 (GRCm39) S270R possibly damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Eya4 G T 10: 23,031,849 (GRCm39) S235Y probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Gdf3 A G 6: 122,584,016 (GRCm39) I117T probably damaging Het
Gm5611 T A 9: 16,941,989 (GRCm39) noncoding transcript Het
Gtf3c4 G A 2: 28,717,567 (GRCm39) T771I probably damaging Het
Hrh3 C A 2: 179,744,643 (GRCm39) R99L possibly damaging Het
Hyls1 T A 9: 35,472,714 (GRCm39) Y234F probably damaging Het
Irak1bp1 T C 9: 82,728,728 (GRCm39) S220P probably benign Het
Lama1 G A 17: 68,071,698 (GRCm39) V862I probably benign Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Or4b12 A T 2: 90,096,684 (GRCm39) L30H probably damaging Het
Pcdh8 T C 14: 80,004,953 (GRCm39) D927G probably damaging Het
Prelid3a T C 18: 67,605,967 (GRCm39) Y25H probably damaging Het
Ptprm T C 17: 67,032,808 (GRCm39) D1015G probably damaging Het
Rhox3f G T X: 36,763,672 (GRCm39) E140* probably null Het
Riox2 C T 16: 59,312,257 (GRCm39) L465F probably benign Het
Sec31b G T 19: 44,512,968 (GRCm39) T507N possibly damaging Het
Stab1 C T 14: 30,890,436 (GRCm39) R5Q probably damaging Het
Stmn3 T C 2: 180,949,089 (GRCm39) K135E possibly damaging Het
Synj2 G A 17: 6,058,240 (GRCm39) G243S probably benign Het
Tasor C T 14: 27,181,918 (GRCm39) R483* probably null Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Tshz2 C A 2: 169,727,450 (GRCm39) P213Q probably benign Het
Tssk4 A G 14: 55,887,830 (GRCm39) T9A probably benign Het
Ube4a T A 9: 44,860,247 (GRCm39) I272F probably damaging Het
Unc79 T C 12: 103,025,629 (GRCm39) C339R probably damaging Het
Vmn2r87 T C 10: 130,315,691 (GRCm39) D125G probably benign Het
Yap1 A T 9: 7,938,432 (GRCm39) *358K probably null Het
Zfp992 C T 4: 146,551,976 (GRCm39) H566Y probably damaging Het
Other mutations in Or14a258
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Or14a258 APN 7 86,035,208 (GRCm39) missense possibly damaging 0.95
IGL02152:Or14a258 APN 7 86,035,251 (GRCm39) missense probably benign 0.00
IGL02540:Or14a258 APN 7 86,035,386 (GRCm39) missense possibly damaging 0.86
IGL03108:Or14a258 APN 7 86,034,929 (GRCm39) missense possibly damaging 0.95
IGL03374:Or14a258 APN 7 86,035,574 (GRCm39) missense probably damaging 1.00
R0040:Or14a258 UTSW 7 86,035,715 (GRCm39) missense probably benign 0.01
R0130:Or14a258 UTSW 7 86,035,514 (GRCm39) missense probably damaging 1.00
R0194:Or14a258 UTSW 7 86,035,582 (GRCm39) nonsense probably null
R0267:Or14a258 UTSW 7 86,035,475 (GRCm39) missense possibly damaging 0.64
R1026:Or14a258 UTSW 7 86,035,467 (GRCm39) missense probably damaging 0.98
R1865:Or14a258 UTSW 7 86,035,769 (GRCm39) missense probably damaging 1.00
R2090:Or14a258 UTSW 7 86,035,289 (GRCm39) missense probably benign 0.01
R3607:Or14a258 UTSW 7 86,034,903 (GRCm39) missense probably benign
R3861:Or14a258 UTSW 7 86,035,331 (GRCm39) missense possibly damaging 0.60
R3909:Or14a258 UTSW 7 86,035,182 (GRCm39) missense probably benign 0.05
R5268:Or14a258 UTSW 7 86,034,867 (GRCm39) makesense probably null
R5649:Or14a258 UTSW 7 86,035,521 (GRCm39) missense probably damaging 1.00
R6343:Or14a258 UTSW 7 86,035,059 (GRCm39) nonsense probably null
R7716:Or14a258 UTSW 7 86,035,262 (GRCm39) missense probably benign 0.22
R8118:Or14a258 UTSW 7 86,034,976 (GRCm39) nonsense probably null
R9047:Or14a258 UTSW 7 86,035,248 (GRCm39) missense probably benign 0.05
R9503:Or14a258 UTSW 7 86,035,228 (GRCm39) missense probably benign 0.00
R9528:Or14a258 UTSW 7 86,035,059 (GRCm39) nonsense probably null
X0054:Or14a258 UTSW 7 86,034,938 (GRCm39) missense probably benign 0.00
X0063:Or14a258 UTSW 7 86,035,700 (GRCm39) missense probably damaging 1.00
Z1186:Or14a258 UTSW 7 86,035,487 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2015-05-14