Mutagenetix > Incidental Mutation

Incidental Mutation 'R4113:Vmn2r87'

314510

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r87

Ensembl Gene

ENSMUSG00000091511

Gene Name

vomeronasal 2, receptor 87

Synonyms

EG625131

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

R4113 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

130471332-130497379 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 130479822 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 125 (D125G)

Ref Sequence

ENSEMBL: ENSMUSP00000129215 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164227]

AlphaFold

E9PZX4

Predicted Effect

probably benign
Transcript: ENSMUST00000164227
AA Change: D125G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: D125G

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	77	422	1.8e-27	PFAM
Pfam:NCD3G	508	562	1.8e-19	PFAM
Pfam:7tm_3	595	829	8.8e-55	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.6%
20x: 96.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bace2	A	G	16: 97,436,656	T436A	probably benign	Het
BC024139	A	G	15: 76,121,627	M458T	probably benign	Het
Casp2	G	A	6: 42,267,894	A76T	probably damaging	Het
Catsper3	A	G	13: 55,786,370	K35E	probably damaging	Het
Ccdc88c	A	G	12: 100,945,073	L34P	probably damaging	Het
Dcaf13	T	A	15: 39,130,220	I236N	probably damaging	Het
Dip2c	G	T	13: 9,637,101	G1254C	probably damaging	Het
Dnah12	T	C	14: 26,693,567	L41P	probably damaging	Het
Dnah17	T	C	11: 118,112,594	K514R	possibly damaging	Het
Dnajb12	T	A	10: 59,894,314	S270R	possibly damaging	Het
Dnajc28	G	A	16: 91,616,867	T187M	probably damaging	Het
Eya4	G	T	10: 23,155,951	S235Y	probably damaging	Het
Fam208a	C	T	14: 27,459,961	R483*	probably null	Het
Fat3	G	A	9: 15,998,271	S2145F	probably damaging	Het
Gdf3	A	G	6: 122,607,057	I117T	probably damaging	Het
Gm5611	T	A	9: 17,030,693		noncoding transcript	Het
Gtf3c4	G	A	2: 28,827,555	T771I	probably damaging	Het
Hrh3	C	A	2: 180,102,850	R99L	possibly damaging	Het
Hyls1	T	A	9: 35,561,418	Y234F	probably damaging	Het
Irak1bp1	T	C	9: 82,846,675	S220P	probably benign	Het
Lama1	G	A	17: 67,764,703	V862I	probably benign	Het
Mrc2	G	A	11: 105,348,431		probably null	Het
Olfr1271	A	T	2: 90,266,340	L30H	probably damaging	Het
Olfr304	G	A	7: 86,386,525	T45M	possibly damaging	Het
Pcdh8	T	C	14: 79,767,513	D927G	probably damaging	Het
Prelid3a	T	C	18: 67,472,897	Y25H	probably damaging	Het
Ptprm	T	C	17: 66,725,813	D1015G	probably damaging	Het
Rhox3f	G	T	X: 37,582,019	E140*	probably null	Het
Riox2	C	T	16: 59,491,894	L465F	probably benign	Het
Sec31b	G	T	19: 44,524,529	T507N	possibly damaging	Het
Stab1	C	T	14: 31,168,479	R5Q	probably damaging	Het
Stmn3	T	C	2: 181,307,296	K135E	possibly damaging	Het
Synj2	G	A	17: 6,007,965	G243S	probably benign	Het
Tns2	C	T	15: 102,108,934	R281C	probably damaging	Het
Tshz2	C	A	2: 169,885,530	P213Q	probably benign	Het
Tssk4	A	G	14: 55,650,373	T9A	probably benign	Het
Ube4a	T	A	9: 44,948,949	I272F	probably damaging	Het
Unc79	T	C	12: 103,059,370	C339R	probably damaging	Het
Yap1	A	T	9: 7,938,431	*358K	probably null	Het
Zfp992	C	T	4: 146,467,519	H566Y	probably damaging	Het

Other mutations in Vmn2r87

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01090:Vmn2r87	APN	10	130497378	start codon destroyed	probably null	1.00
IGL01295:Vmn2r87	APN	10	130472009	missense	probably damaging	1.00
IGL01411:Vmn2r87	APN	10	130472560	missense	probably benign	0.03
IGL01680:Vmn2r87	APN	10	130479717	nonsense	probably null
IGL01822:Vmn2r87	APN	10	130472122	missense	probably damaging	1.00
IGL01835:Vmn2r87	APN	10	130479109	missense	probably damaging	1.00
IGL01965:Vmn2r87	APN	10	130479055	missense	possibly damaging	0.49
IGL02562:Vmn2r87	APN	10	130478644	missense	probably damaging	1.00
IGL02665:Vmn2r87	APN	10	130497180	missense	probably benign	0.16
IGL03202:Vmn2r87	APN	10	130497222	missense	probably benign
FR4304:Vmn2r87	UTSW	10	130478714	missense	probably benign	0.01
FR4340:Vmn2r87	UTSW	10	130478714	missense	probably benign	0.01
FR4342:Vmn2r87	UTSW	10	130478714	missense	probably benign	0.01
FR4589:Vmn2r87	UTSW	10	130478714	missense	probably benign	0.01
LCD18:Vmn2r87	UTSW	10	130478714	missense	probably benign	0.01
R0344:Vmn2r87	UTSW	10	130479937	missense	probably damaging	1.00
R0374:Vmn2r87	UTSW	10	130471979	missense	probably damaging	1.00
R0384:Vmn2r87	UTSW	10	130471843	missense	probably benign
R1144:Vmn2r87	UTSW	10	130476229	splice site	probably benign
R1172:Vmn2r87	UTSW	10	130477584	missense	probably benign	0.03
R1860:Vmn2r87	UTSW	10	130479886	missense	probably benign	0.00
R1866:Vmn2r87	UTSW	10	130472572	missense	possibly damaging	0.88
R1897:Vmn2r87	UTSW	10	130471960	missense	probably damaging	1.00
R2360:Vmn2r87	UTSW	10	130479762	missense	probably damaging	0.99
R2909:Vmn2r87	UTSW	10	130478996	missense	probably damaging	0.99
R3874:Vmn2r87	UTSW	10	130479987	missense	possibly damaging	0.62
R4190:Vmn2r87	UTSW	10	130472687	missense	probably damaging	1.00
R4197:Vmn2r87	UTSW	10	130479910	missense	possibly damaging	0.55
R4201:Vmn2r87	UTSW	10	130472579	missense	probably benign	0.03
R4202:Vmn2r87	UTSW	10	130472579	missense	probably benign	0.03
R4368:Vmn2r87	UTSW	10	130479807	missense	probably benign	0.44
R4485:Vmn2r87	UTSW	10	130479809	nonsense	probably null
R4537:Vmn2r87	UTSW	10	130472185	missense	probably benign	0.12
R4590:Vmn2r87	UTSW	10	130479145	missense	possibly damaging	0.69
R4752:Vmn2r87	UTSW	10	130478467	nonsense	probably null
R4873:Vmn2r87	UTSW	10	130472498	missense	probably damaging	1.00
R4875:Vmn2r87	UTSW	10	130472498	missense	probably damaging	1.00
R4923:Vmn2r87	UTSW	10	130478566	missense	probably damaging	0.99
R4970:Vmn2r87	UTSW	10	130478553	missense	probably damaging	1.00
R5049:Vmn2r87	UTSW	10	130472429	missense	probably damaging	0.96
R5112:Vmn2r87	UTSW	10	130478553	missense	probably damaging	1.00
R5187:Vmn2r87	UTSW	10	130497339	missense	probably null	0.99
R5618:Vmn2r87	UTSW	10	130479948	missense	probably damaging	1.00
R6057:Vmn2r87	UTSW	10	130472357	missense	probably benign	0.02
R6220:Vmn2r87	UTSW	10	130479938	missense	probably benign	0.01
R6287:Vmn2r87	UTSW	10	130478422	critical splice donor site	probably null
R6383:Vmn2r87	UTSW	10	130479000	missense	probably damaging	1.00
R6576:Vmn2r87	UTSW	10	130478785	missense	probably benign	0.05
R6742:Vmn2r87	UTSW	10	130472527	missense	probably damaging	1.00
R7086:Vmn2r87	UTSW	10	130497309	missense	probably benign	0.00
R7162:Vmn2r87	UTSW	10	130477547	missense	probably benign	0.08
R7419:Vmn2r87	UTSW	10	130472123	missense	probably damaging	1.00
R7425:Vmn2r87	UTSW	10	130478892	missense	probably damaging	1.00
R7443:Vmn2r87	UTSW	10	130472719	missense	probably damaging	1.00
R7571:Vmn2r87	UTSW	10	130479071	missense	probably damaging	0.99
R7663:Vmn2r87	UTSW	10	130472185	missense	probably damaging	0.97
R7716:Vmn2r87	UTSW	10	130472149	missense	probably benign	0.09
R7793:Vmn2r87	UTSW	10	130477544	missense	probably benign	0.05
R7806:Vmn2r87	UTSW	10	130479810	missense	probably benign
R7841:Vmn2r87	UTSW	10	130497226	missense	probably benign	0.31
R8326:Vmn2r87	UTSW	10	130472311	missense	possibly damaging	0.67
R8411:Vmn2r87	UTSW	10	130472257	missense	probably damaging	0.99
R8445:Vmn2r87	UTSW	10	130477466	missense	probably damaging	1.00
R8540:Vmn2r87	UTSW	10	130478893	missense	possibly damaging	0.74
R8892:Vmn2r87	UTSW	10	130472236	missense	probably damaging	0.99
R9093:Vmn2r87	UTSW	10	130472296	missense	probably benign	0.08
R9623:Vmn2r87	UTSW	10	130479925	missense	probably damaging	1.00
R9667:Vmn2r87	UTSW	10	130478907	missense	probably damaging	1.00
R9797:Vmn2r87	UTSW	10	130472269	missense	probably damaging	0.99
R9797:Vmn2r87	UTSW	10	130476195	missense	probably benign	0.44
Z1088:Vmn2r87	UTSW	10	130472314	missense	probably damaging	0.98
Z1176:Vmn2r87	UTSW	10	130471844	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- CACACTCATAAATGCATGCTGTCC -3'
(R):5'- CACCTCTTGTAATCATCACTATGAC -3'

Sequencing Primer
(F):5'- CTTTTCTTGTAGGCACCTGTAAATG -3'
(R):5'- GACTTGTTTTAGAATACCAGCAAGTG -3'

Posted On

2015-05-14