Incidental Mutation 'R4131:Prelid2'
ID 314689
Institutional Source Beutler Lab
Gene Symbol Prelid2
Ensembl Gene ENSMUSG00000056671
Gene Name PRELI domain containing 2
Synonyms C330008K14Rik, 1700003A01Rik
MMRRC Submission 040994-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4131 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 42008761-42084259 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 42084224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 6 (D6A)
Ref Sequence ENSEMBL: ENSMUSP00000064661 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070949]
AlphaFold Q0VBB0
Predicted Effect possibly damaging
Transcript: ENSMUST00000070949
AA Change: D6A

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000064661
Gene: ENSMUSG00000056671
AA Change: D6A

DomainStartEndE-ValueType
Pfam:PRELI 16 173 2.8e-51 PFAM
Meta Mutation Damage Score 0.1688 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt A G 9: 99,502,671 (GRCm39) D277G possibly damaging Het
Abca12 A G 1: 71,359,030 (GRCm39) probably null Het
Adam12 C T 7: 133,514,653 (GRCm39) V345I probably damaging Het
Arpp21 T A 9: 111,984,376 (GRCm39) probably benign Het
Art3 A T 5: 92,540,421 (GRCm39) M55L probably benign Het
C1d C T 11: 17,214,054 (GRCm39) probably benign Het
Ces1c A G 8: 93,827,312 (GRCm39) M484T probably damaging Het
Cisd3 T C 11: 97,579,257 (GRCm39) V133A possibly damaging Het
Clpx A G 9: 65,223,937 (GRCm39) I230V possibly damaging Het
Cmklr1 C A 5: 113,752,545 (GRCm39) R152L probably damaging Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Heca A G 10: 17,777,987 (GRCm39) S537P probably damaging Het
Igha C A 12: 113,222,449 (GRCm39) probably benign Het
Itgb2l A G 16: 96,238,589 (GRCm39) L70P probably damaging Het
Klk1b3 T A 7: 43,851,111 (GRCm39) N181K probably damaging Het
Klra2 T A 6: 131,205,180 (GRCm39) R220S probably benign Het
Lama2 C T 10: 26,917,170 (GRCm39) V2252I probably benign Het
Megf10 G A 18: 57,313,607 (GRCm39) C17Y probably damaging Het
Nup35 G A 2: 80,486,443 (GRCm39) probably benign Het
Or52n4b C G 7: 108,143,744 (GRCm39) S2* probably null Het
Or8b37 T A 9: 37,959,170 (GRCm39) Y217* probably null Het
Pdzd9 A T 7: 120,262,092 (GRCm39) D123E possibly damaging Het
Phactr1 A T 13: 43,190,953 (GRCm39) Q141L probably damaging Het
Psmd1 T C 1: 86,006,422 (GRCm39) S263P probably damaging Het
Rassf6 C T 5: 90,757,646 (GRCm39) D105N probably damaging Het
Ryr3 C T 2: 112,757,328 (GRCm39) probably null Het
Sema4g T A 19: 44,987,358 (GRCm39) F501L probably benign Het
Ssrp1 A G 2: 84,874,791 (GRCm39) E537G probably null Het
Try4 T A 6: 41,282,335 (GRCm39) Y218* probably null Het
Zbtb40 G T 4: 136,722,707 (GRCm39) S790R probably benign Het
Other mutations in Prelid2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00709:Prelid2 APN 18 42,045,488 (GRCm39) missense probably damaging 1.00
IGL01731:Prelid2 APN 18 42,070,714 (GRCm39) missense probably benign 0.03
G1patch:Prelid2 UTSW 18 42,045,514 (GRCm39) missense possibly damaging 0.82
R0217:Prelid2 UTSW 18 42,068,317 (GRCm39) splice site probably benign
R0556:Prelid2 UTSW 18 42,084,245 (GRCm39) start gained probably benign
R0627:Prelid2 UTSW 18 42,070,717 (GRCm39) missense possibly damaging 0.50
R0848:Prelid2 UTSW 18 42,068,289 (GRCm39) missense probably damaging 0.98
R1522:Prelid2 UTSW 18 42,014,332 (GRCm39) missense probably benign
R3919:Prelid2 UTSW 18 42,070,740 (GRCm39) missense possibly damaging 0.79
R4422:Prelid2 UTSW 18 42,045,461 (GRCm39) missense probably benign 0.01
R4892:Prelid2 UTSW 18 42,084,209 (GRCm39) missense possibly damaging 0.86
R6062:Prelid2 UTSW 18 42,045,530 (GRCm39) missense probably benign 0.00
R6725:Prelid2 UTSW 18 42,045,514 (GRCm39) missense possibly damaging 0.82
R7276:Prelid2 UTSW 18 42,045,487 (GRCm39) missense possibly damaging 0.65
R7739:Prelid2 UTSW 18 42,045,433 (GRCm39) critical splice donor site probably null
R7941:Prelid2 UTSW 18 42,065,816 (GRCm39) nonsense probably null
R8093:Prelid2 UTSW 18 42,065,700 (GRCm39) missense probably damaging 1.00
R8202:Prelid2 UTSW 18 42,065,802 (GRCm39) missense possibly damaging 0.95
R8393:Prelid2 UTSW 18 42,014,313 (GRCm39) missense probably benign 0.08
R9010:Prelid2 UTSW 18 42,065,781 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTCGAGGAAAACCGCCTC -3'
(R):5'- TGGTGAGCGCTTTATAGGAC -3'

Sequencing Primer
(F):5'- TGCACATCCCGGGAGCAG -3'
(R):5'- CGTAAGTGAAAGGGGATGTGG -3'
Posted On 2015-05-14