Incidental Mutation 'R4133:Ddx60'
ID 314745
Institutional Source Beutler Lab
Gene Symbol Ddx60
Ensembl Gene ENSMUSG00000037921
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Synonyms
MMRRC Submission 041637-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R4133 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 61928087-62038244 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 61972220 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 681 (K681E)
Ref Sequence ENSEMBL: ENSMUSP00000091197 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070631] [ENSMUST00000093485]
AlphaFold E9PZQ1
Predicted Effect probably damaging
Transcript: ENSMUST00000070631
AA Change: K680E

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000070741
Gene: ENSMUSG00000037921
AA Change: K680E

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
DEXDc 758 949 1.05e-15 SMART
Blast:DEXDc 1007 1132 4e-24 BLAST
HELICc 1245 1328 4.35e-13 SMART
low complexity region 1362 1373 N/A INTRINSIC
Blast:DEXDc 1503 1584 1e-20 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000093485
AA Change: K681E

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000091197
Gene: ENSMUSG00000037921
AA Change: K681E

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
DEXDc 759 950 1.05e-15 SMART
Blast:DEXDc 1008 1133 4e-24 BLAST
HELICc 1246 1329 4.35e-13 SMART
low complexity region 1363 1374 N/A INTRINSIC
Blast:DEXDc 1504 1585 1e-20 BLAST
Meta Mutation Damage Score 0.1456 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 97% (77/79)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal immunity to several viruses (IAV, EMCV, SINV) but increased susceptibility to VSV infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700036A12Rik T A 9: 60,769,998 (GRCm38) noncoding transcript Het
Aldh3b1 A G 19: 3,920,808 (GRCm38) I184T probably damaging Het
Arhgap42 C T 9: 9,011,299 (GRCm38) probably benign Het
Arhgef4 A G 1: 34,806,104 (GRCm38) D1463G probably damaging Het
Arpc5 A G 1: 152,768,871 (GRCm38) T52A probably benign Het
Asb6 A G 2: 30,828,235 (GRCm38) probably benign Het
Ash1l T C 3: 88,982,260 (GRCm38) V482A probably benign Het
Bop1 T C 15: 76,454,335 (GRCm38) N469S probably benign Het
Btaf1 T A 19: 36,961,738 (GRCm38) N266K probably benign Het
Btla T C 16: 45,239,298 (GRCm38) Y122H probably damaging Het
Cacna1g A G 11: 94,432,544 (GRCm38) M1278T probably damaging Het
Cdc42bpb A G 12: 111,321,542 (GRCm38) S524P probably benign Het
Cep78 A G 19: 15,969,155 (GRCm38) S438P probably damaging Het
Clca4a T G 3: 144,969,352 (GRCm38) E171D probably benign Het
Cldn6 A T 17: 23,681,493 (GRCm38) I144F probably damaging Het
Cpd G A 11: 76,814,818 (GRCm38) Q363* probably null Het
Cpn1 G A 19: 43,986,284 (GRCm38) P2L possibly damaging Het
Ddx31 A G 2: 28,858,852 (GRCm38) D264G probably damaging Het
Ddx39b C T 17: 35,253,089 (GRCm38) S368L probably damaging Het
Dennd1c A C 17: 57,076,980 (GRCm38) W15G possibly damaging Het
Dgkd T G 1: 87,941,501 (GRCm38) probably null Het
Dnah7c G T 1: 46,665,990 (GRCm38) A2388S probably benign Het
Etv4 C A 11: 101,770,498 (GRCm38) K442N probably damaging Het
Fam234a T C 17: 26,213,558 (GRCm38) D539G probably damaging Het
Fam71a A T 1: 191,163,008 (GRCm38) N479K probably benign Het
Fancm A G 12: 65,120,530 (GRCm38) T1538A probably benign Het
Fbn2 A T 18: 58,095,962 (GRCm38) N725K possibly damaging Het
Fcer2a T A 8: 3,691,130 (GRCm38) N4I possibly damaging Het
Fgd5 T C 6: 92,069,437 (GRCm38) V1229A probably damaging Het
Gm5471 A T 15: 44,971,901 (GRCm38) noncoding transcript Het
Gm5478 T A 15: 101,644,645 (GRCm38) I331F probably damaging Het
Gm6729 C A 10: 86,541,166 (GRCm38) noncoding transcript Het
Hectd4 G T 5: 121,277,834 (GRCm38) probably null Het
Hspb3 A C 13: 113,663,491 (GRCm38) M1R probably null Het
Igkv10-95 T C 6: 68,680,617 (GRCm38) V19A probably damaging Het
Il1rap A G 16: 26,722,886 (GRCm38) S626G probably benign Het
Ints9 A G 14: 64,990,554 (GRCm38) H103R probably benign Het
Itga4 T A 2: 79,322,652 (GRCm38) D894E probably damaging Het
Khsrp T C 17: 57,025,605 (GRCm38) H225R probably benign Het
Lama1 A T 17: 67,812,486 (GRCm38) I2653F probably damaging Het
Lama1 T C 17: 67,750,655 (GRCm38) Y575H probably damaging Het
Map4k5 A T 12: 69,845,723 (GRCm38) L144Q probably damaging Het
Mcm5 A G 8: 75,115,854 (GRCm38) Y252C probably damaging Het
Mmgt2 A G 11: 62,665,051 (GRCm38) E75G probably damaging Het
Mroh2a A T 1: 88,254,965 (GRCm38) N1205I possibly damaging Het
Nckap5 A G 1: 126,222,706 (GRCm38) V162A probably benign Het
Nr3c2 T C 8: 76,909,749 (GRCm38) I493T probably damaging Het
Olfr1411 T C 1: 92,596,743 (GRCm38) F75L probably benign Het
Olfr325 A T 11: 58,581,075 (GRCm38) Y77F probably damaging Het
Olfr698 A C 7: 106,753,079 (GRCm38) L103R probably damaging Het
Papola A G 12: 105,799,658 (GRCm38) T6A possibly damaging Het
Ppp1cc G A 5: 122,168,226 (GRCm38) R36Q probably benign Het
Ptpro G T 6: 137,420,372 (GRCm38) W81C probably damaging Het
Rasgrf2 A G 13: 91,982,654 (GRCm38) S162P possibly damaging Het
Rpusd2 T C 2: 119,038,715 (GRCm38) S540P probably damaging Het
Scn5a T A 9: 119,486,372 (GRCm38) T1757S probably damaging Het
Setbp1 T C 18: 78,856,991 (GRCm38) I1154V probably benign Het
Sirt1 T C 10: 63,335,659 (GRCm38) I209V probably null Het
Slco6c1 T A 1: 97,081,493 (GRCm38) I406L probably benign Het
Smc2 A G 4: 52,450,947 (GRCm38) E255G probably damaging Het
Snap91 C A 9: 86,777,049 (GRCm38) G477V probably damaging Het
Speg A G 1: 75,427,904 (GRCm38) Q2780R probably benign Het
Ssh2 A G 11: 77,421,269 (GRCm38) Y196C probably damaging Het
Ssxb9 A T X: 8,369,606 (GRCm38) T18S probably damaging Het
Stxbp5l T C 16: 37,208,119 (GRCm38) I527M possibly damaging Het
Tex10 T C 4: 48,468,968 (GRCm38) Y69C probably damaging Het
Theg T C 10: 79,580,050 (GRCm38) T236A probably damaging Het
Thoc3 T C 13: 54,468,548 (GRCm38) D87G probably benign Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Trps1 T C 15: 50,831,387 (GRCm38) K213R probably damaging Het
Uggt1 A T 1: 36,158,159 (GRCm38) L1221Q probably damaging Het
Vmn2r3 T A 3: 64,275,717 (GRCm38) Y187F probably damaging Het
Washc2 G A 6: 116,258,930 (GRCm38) E1121K probably damaging Het
Zfx T C X: 94,080,858 (GRCm38) N360D probably damaging Het
Znhit3 A G 11: 84,916,313 (GRCm38) V10A probably benign Het
Other mutations in Ddx60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Ddx60 APN 8 61,958,646 (GRCm38) missense probably damaging 1.00
IGL00915:Ddx60 APN 8 61,987,431 (GRCm38) missense possibly damaging 0.79
IGL00931:Ddx60 APN 8 61,969,583 (GRCm38) missense probably benign 0.18
IGL01023:Ddx60 APN 8 61,942,514 (GRCm38) missense probably damaging 0.99
IGL01313:Ddx60 APN 8 61,982,526 (GRCm38) missense probably damaging 1.00
IGL01615:Ddx60 APN 8 61,963,740 (GRCm38) missense probably null 0.81
IGL01733:Ddx60 APN 8 61,983,865 (GRCm38) missense probably damaging 0.99
IGL01779:Ddx60 APN 8 62,017,823 (GRCm38) missense possibly damaging 0.94
IGL01900:Ddx60 APN 8 62,000,709 (GRCm38) splice site probably benign
IGL02110:Ddx60 APN 8 62,017,247 (GRCm38) critical splice donor site probably null
IGL02302:Ddx60 APN 8 61,975,832 (GRCm38) missense possibly damaging 0.85
IGL02468:Ddx60 APN 8 61,958,642 (GRCm38) missense probably damaging 1.00
IGL02569:Ddx60 APN 8 62,024,951 (GRCm38) missense possibly damaging 0.93
IGL02622:Ddx60 APN 8 61,942,436 (GRCm38) splice site probably null
IGL02657:Ddx60 APN 8 61,984,115 (GRCm38) missense probably benign 0.01
IGL02677:Ddx60 APN 8 61,988,132 (GRCm38) missense probably damaging 1.00
IGL02701:Ddx60 APN 8 61,979,341 (GRCm38) missense probably damaging 0.96
IGL02806:Ddx60 APN 8 61,956,122 (GRCm38) missense probably benign 0.00
IGL03137:Ddx60 APN 8 61,988,083 (GRCm38) missense possibly damaging 0.61
IGL03295:Ddx60 APN 8 61,956,121 (GRCm38) missense possibly damaging 0.82
IGL03387:Ddx60 APN 8 62,012,449 (GRCm38) missense probably damaging 1.00
IGL03411:Ddx60 APN 8 61,977,882 (GRCm38) critical splice acceptor site probably null
Scatter UTSW 8 62,021,314 (GRCm38) missense possibly damaging 0.80
shotgun UTSW 8 62,037,067 (GRCm38) missense probably benign 0.28
splay UTSW 8 62,021,309 (GRCm38) missense possibly damaging 0.80
G1Funyon:Ddx60 UTSW 8 62,000,597 (GRCm38) missense probably benign 0.01
PIT4504001:Ddx60 UTSW 8 61,958,113 (GRCm38) missense probably benign
PIT4677001:Ddx60 UTSW 8 61,972,254 (GRCm38) missense possibly damaging 0.87
R0090:Ddx60 UTSW 8 61,942,293 (GRCm38) missense probably damaging 1.00
R0266:Ddx60 UTSW 8 62,033,493 (GRCm38) missense possibly damaging 0.92
R0325:Ddx60 UTSW 8 61,983,855 (GRCm38) missense probably benign 0.00
R0367:Ddx60 UTSW 8 62,017,749 (GRCm38) missense possibly damaging 0.78
R0403:Ddx60 UTSW 8 61,994,541 (GRCm38) splice site probably benign
R0479:Ddx60 UTSW 8 61,969,657 (GRCm38) missense probably damaging 1.00
R0561:Ddx60 UTSW 8 62,017,794 (GRCm38) missense possibly damaging 0.93
R0844:Ddx60 UTSW 8 61,987,361 (GRCm38) missense probably benign 0.27
R1119:Ddx60 UTSW 8 61,942,544 (GRCm38) missense probably damaging 1.00
R1428:Ddx60 UTSW 8 61,958,159 (GRCm38) splice site probably benign
R1778:Ddx60 UTSW 8 61,974,176 (GRCm38) missense possibly damaging 0.85
R1840:Ddx60 UTSW 8 61,969,553 (GRCm38) missense probably damaging 0.99
R1964:Ddx60 UTSW 8 61,948,869 (GRCm38) missense probably benign 0.10
R1970:Ddx60 UTSW 8 61,972,206 (GRCm38) missense possibly damaging 0.93
R2101:Ddx60 UTSW 8 61,940,645 (GRCm38) missense probably damaging 1.00
R2174:Ddx60 UTSW 8 62,017,200 (GRCm38) missense probably benign 0.01
R2174:Ddx60 UTSW 8 61,956,141 (GRCm38) missense probably damaging 1.00
R2198:Ddx60 UTSW 8 61,958,063 (GRCm38) missense possibly damaging 0.79
R2332:Ddx60 UTSW 8 62,037,091 (GRCm38) missense probably benign 0.08
R2338:Ddx60 UTSW 8 62,012,436 (GRCm38) missense possibly damaging 0.91
R2379:Ddx60 UTSW 8 62,037,088 (GRCm38) missense probably damaging 1.00
R4010:Ddx60 UTSW 8 61,956,144 (GRCm38) missense probably benign 0.25
R4010:Ddx60 UTSW 8 61,954,535 (GRCm38) missense possibly damaging 0.65
R4282:Ddx60 UTSW 8 61,994,393 (GRCm38) missense probably damaging 0.99
R4382:Ddx60 UTSW 8 61,948,978 (GRCm38) splice site probably null
R4561:Ddx60 UTSW 8 61,942,461 (GRCm38) missense probably damaging 0.96
R4572:Ddx60 UTSW 8 61,987,421 (GRCm38) missense probably damaging 1.00
R4581:Ddx60 UTSW 8 62,023,261 (GRCm38) missense possibly damaging 0.90
R4635:Ddx60 UTSW 8 62,037,067 (GRCm38) missense probably benign 0.28
R4698:Ddx60 UTSW 8 62,012,424 (GRCm38) missense probably benign 0.01
R4807:Ddx60 UTSW 8 61,979,338 (GRCm38) missense probably damaging 1.00
R4858:Ddx60 UTSW 8 62,021,314 (GRCm38) missense possibly damaging 0.80
R4964:Ddx60 UTSW 8 61,979,338 (GRCm38) missense probably damaging 1.00
R5120:Ddx60 UTSW 8 61,945,906 (GRCm38) missense probably benign 0.01
R5187:Ddx60 UTSW 8 61,974,188 (GRCm38) missense probably damaging 1.00
R5222:Ddx60 UTSW 8 61,984,158 (GRCm38) missense probably damaging 0.99
R5400:Ddx60 UTSW 8 62,010,002 (GRCm38) missense possibly damaging 0.65
R5500:Ddx60 UTSW 8 61,950,451 (GRCm38) missense probably benign 0.28
R5514:Ddx60 UTSW 8 61,958,057 (GRCm38) missense probably damaging 1.00
R5668:Ddx60 UTSW 8 62,000,578 (GRCm38) missense probably benign 0.38
R5742:Ddx60 UTSW 8 61,948,921 (GRCm38) missense probably benign
R5772:Ddx60 UTSW 8 61,948,897 (GRCm38) missense probably damaging 1.00
R5810:Ddx60 UTSW 8 62,012,388 (GRCm38) nonsense probably null
R5815:Ddx60 UTSW 8 61,963,722 (GRCm38) missense probably damaging 0.98
R5820:Ddx60 UTSW 8 61,956,121 (GRCm38) missense possibly damaging 0.82
R5866:Ddx60 UTSW 8 61,940,740 (GRCm38) missense probably damaging 1.00
R5881:Ddx60 UTSW 8 62,037,070 (GRCm38) missense probably damaging 1.00
R5977:Ddx60 UTSW 8 62,021,410 (GRCm38) critical splice donor site probably null
R6048:Ddx60 UTSW 8 62,000,582 (GRCm38) missense probably benign 0.01
R6061:Ddx60 UTSW 8 62,023,241 (GRCm38) missense probably null 0.01
R6153:Ddx60 UTSW 8 61,945,940 (GRCm38) missense possibly damaging 0.47
R6287:Ddx60 UTSW 8 61,950,578 (GRCm38) missense probably damaging 1.00
R6415:Ddx60 UTSW 8 61,983,905 (GRCm38) missense probably benign 0.00
R6416:Ddx60 UTSW 8 61,998,681 (GRCm38) missense probably benign
R6416:Ddx60 UTSW 8 61,977,950 (GRCm38) missense probably benign 0.00
R6660:Ddx60 UTSW 8 61,956,239 (GRCm38) missense probably benign 0.00
R6694:Ddx60 UTSW 8 62,037,070 (GRCm38) missense probably damaging 1.00
R6715:Ddx60 UTSW 8 61,983,890 (GRCm38) missense probably benign 0.03
R6720:Ddx60 UTSW 8 62,000,689 (GRCm38) missense probably benign 0.10
R6937:Ddx60 UTSW 8 62,037,069 (GRCm38) missense probably damaging 1.00
R7153:Ddx60 UTSW 8 61,988,108 (GRCm38) missense possibly damaging 0.71
R7274:Ddx60 UTSW 8 61,940,108 (GRCm38) critical splice donor site probably null
R7409:Ddx60 UTSW 8 61,958,578 (GRCm38) missense probably benign 0.24
R7464:Ddx60 UTSW 8 61,940,674 (GRCm38) missense possibly damaging 0.82
R7670:Ddx60 UTSW 8 61,975,792 (GRCm38) missense probably damaging 1.00
R7904:Ddx60 UTSW 8 61,977,890 (GRCm38) missense possibly damaging 0.81
R7992:Ddx60 UTSW 8 61,954,535 (GRCm38) missense probably benign 0.03
R8124:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8125:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8126:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8155:Ddx60 UTSW 8 62,017,171 (GRCm38) missense possibly damaging 0.61
R8174:Ddx60 UTSW 8 62,017,250 (GRCm38) splice site probably null
R8192:Ddx60 UTSW 8 61,977,968 (GRCm38) missense probably damaging 1.00
R8271:Ddx60 UTSW 8 61,940,108 (GRCm38) critical splice donor site probably null
R8301:Ddx60 UTSW 8 62,000,597 (GRCm38) missense probably benign 0.01
R8304:Ddx60 UTSW 8 61,998,769 (GRCm38) missense possibly damaging 0.67
R8319:Ddx60 UTSW 8 61,942,635 (GRCm38) critical splice donor site probably null
R8374:Ddx60 UTSW 8 61,974,171 (GRCm38) missense probably benign 0.01
R8401:Ddx60 UTSW 8 61,956,243 (GRCm38) missense possibly damaging 0.57
R8487:Ddx60 UTSW 8 61,974,150 (GRCm38) missense probably damaging 1.00
R8804:Ddx60 UTSW 8 61,958,606 (GRCm38) missense probably benign 0.27
R8826:Ddx60 UTSW 8 61,945,956 (GRCm38) missense probably benign 0.02
R8829:Ddx60 UTSW 8 61,940,661 (GRCm38) missense probably damaging 1.00
R8881:Ddx60 UTSW 8 62,021,309 (GRCm38) missense possibly damaging 0.80
R8884:Ddx60 UTSW 8 61,994,519 (GRCm38) missense possibly damaging 0.86
R8990:Ddx60 UTSW 8 61,974,134 (GRCm38) nonsense probably null
R9122:Ddx60 UTSW 8 61,989,864 (GRCm38) missense probably benign 0.16
R9225:Ddx60 UTSW 8 62,017,841 (GRCm38) missense probably benign 0.36
R9278:Ddx60 UTSW 8 61,977,978 (GRCm38) missense possibly damaging 0.83
R9293:Ddx60 UTSW 8 62,009,960 (GRCm38) missense possibly damaging 0.89
R9405:Ddx60 UTSW 8 61,972,214 (GRCm38) missense probably benign 0.03
R9766:Ddx60 UTSW 8 62,012,278 (GRCm38) missense probably damaging 1.00
X0003:Ddx60 UTSW 8 62,033,417 (GRCm38) missense possibly damaging 0.88
X0019:Ddx60 UTSW 8 61,963,692 (GRCm38) missense probably benign 0.01
Z1177:Ddx60 UTSW 8 62,000,588 (GRCm38) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- TGGTGAGTAAGAGAGTAAGTGTCATG -3'
(R):5'- GTGCAAACACAGCTCTTTTAGAATT -3'

Sequencing Primer
(F):5'- TAAGCTAGGTGGTTGAGC -3'
(R):5'- TCCCCAAGAGAAGGTTGGTC -3'
Posted On 2015-05-14