Incidental Mutation 'R4155:Tmem232'
ID 315113
Institutional Source Beutler Lab
Gene Symbol Tmem232
Ensembl Gene ENSMUSG00000045036
Gene Name transmembrane protein 232
Synonyms LOC381107, E130009J12Rik
MMRRC Submission 040999-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R4155 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 65256005-65540782 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 65436333 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 321 (M321K)
Ref Sequence ENSEMBL: ENSMUSP00000083927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062161] [ENSMUST00000086722]
AlphaFold Q5K6N0
Predicted Effect probably damaging
Transcript: ENSMUST00000062161
AA Change: M321K

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000055652
Gene: ENSMUSG00000045036
AA Change: M321K

DomainStartEndE-ValueType
Pfam:TMEM232 40 488 5.3e-235 PFAM
coiled coil region 598 634 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000086722
AA Change: M321K

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000083927
Gene: ENSMUSG00000045036
AA Change: M321K

DomainStartEndE-ValueType
low complexity region 61 67 N/A INTRINSIC
coiled coil region 598 634 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410004B18Rik T A 3: 145,938,263 (GRCm38) F69I possibly damaging Het
Akt3 A G 1: 177,096,977 (GRCm38) I184T possibly damaging Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 118,121,899 (GRCm38) probably benign Het
Armc2 A G 10: 42,011,867 (GRCm38) V40A probably damaging Het
Ash2l A G 8: 25,817,454 (GRCm38) Y485H probably damaging Het
Atr T A 9: 95,888,124 (GRCm38) C1202* probably null Het
Bcl11b A T 12: 107,917,425 (GRCm38) probably null Het
Birc6 C A 17: 74,596,939 (GRCm38) S1242R probably benign Het
Blm GCCTCCTCCTCCTCCTCCTCCTCCTCCTCC GCCTCCTCCTCCTCCTCCTCCTCCTCC 7: 80,512,904 (GRCm38) probably benign Het
Bsx A G 9: 40,876,336 (GRCm38) E102G probably benign Het
Casq2 A T 3: 102,133,102 (GRCm38) probably null Het
Ccpg1 C A 9: 73,012,167 (GRCm38) Q355K probably benign Het
Copa T G 1: 172,101,425 (GRCm38) N251K probably damaging Het
Cst8 C A 2: 148,800,076 (GRCm38) A31E possibly damaging Het
D6Ertd527e C G 6: 87,111,524 (GRCm38) T223S unknown Het
Ecd A G 14: 20,324,564 (GRCm38) S503P probably damaging Het
Fbn2 C A 18: 58,023,287 (GRCm38) E2487* probably null Het
Hoxd9 A G 2: 74,699,323 (GRCm38) I308V probably benign Het
Ica1l G A 1: 60,013,893 (GRCm38) A162V possibly damaging Het
Kcnj15 A T 16: 95,296,307 (GRCm38) K263* probably null Het
Mettl4 T C 17: 94,740,575 (GRCm38) M213V probably benign Het
Nalf1 T A 8: 9,233,023 (GRCm38) Y342F possibly damaging Het
Ncan C A 8: 70,110,077 (GRCm38) E510D possibly damaging Het
Ndufs4 A T 13: 114,307,854 (GRCm38) S129R probably benign Het
Or14a259 T A 7: 86,364,062 (GRCm38) I92L probably benign Het
Or4c127 A G 2: 90,002,660 (GRCm38) S85G probably benign Het
Or52s19 T C 7: 103,359,156 (GRCm38) T13A probably benign Het
Or8d1b A T 9: 38,976,155 (GRCm38) T160S probably damaging Het
P2rx5 A G 11: 73,171,829 (GRCm38) T455A probably damaging Het
Pcdh1 T A 18: 38,203,106 (GRCm38) T159S probably damaging Het
Poln A G 5: 34,009,649 (GRCm38) V755A possibly damaging Het
Pou4f1 C T 14: 104,467,717 (GRCm38) S6N possibly damaging Het
Rpap1 C T 2: 119,774,179 (GRCm38) R416H probably damaging Het
Samd4 T A 14: 47,052,946 (GRCm38) M170K possibly damaging Het
Srgn A G 10: 62,497,834 (GRCm38) F55L possibly damaging Het
Tmcc1 C T 6: 116,133,804 (GRCm38) G176D probably benign Het
Tnfsf11 A G 14: 78,299,869 (GRCm38) M118T probably benign Het
Tns1 T A 1: 73,914,631 (GRCm38) N1848Y probably damaging Het
Ttc27 T G 17: 74,840,460 (GRCm38) I669S probably benign Het
Uaca A G 9: 60,871,753 (GRCm38) S1141G probably benign Het
Usp34 T A 11: 23,417,676 (GRCm38) V1671E probably damaging Het
Wdr64 T A 1: 175,769,606 (GRCm38) L73H probably benign Het
Zfp410 G A 12: 84,327,432 (GRCm38) R181H probably damaging Het
Other mutations in Tmem232
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Tmem232 APN 17 65,256,574 (GRCm38) missense possibly damaging 0.71
IGL00954:Tmem232 APN 17 65,500,153 (GRCm38) missense probably damaging 1.00
IGL01530:Tmem232 APN 17 65,256,548 (GRCm38) nonsense probably null
IGL02881:Tmem232 APN 17 65,450,370 (GRCm38) missense probably damaging 1.00
IGL02969:Tmem232 APN 17 65,256,563 (GRCm38) missense possibly damaging 0.69
IGL02972:Tmem232 APN 17 65,476,673 (GRCm38) missense probably benign 0.00
IGL03028:Tmem232 APN 17 65,256,389 (GRCm38) missense probably benign 0.14
IGL03293:Tmem232 APN 17 65,450,374 (GRCm38) missense probably damaging 1.00
R0380:Tmem232 UTSW 17 65,256,448 (GRCm38) missense probably benign 0.23
R0432:Tmem232 UTSW 17 65,256,503 (GRCm38) missense probably damaging 0.99
R0524:Tmem232 UTSW 17 65,485,942 (GRCm38) missense probably damaging 0.98
R0548:Tmem232 UTSW 17 65,382,620 (GRCm38) missense probably benign 0.22
R1345:Tmem232 UTSW 17 65,450,406 (GRCm38) missense possibly damaging 0.60
R1521:Tmem232 UTSW 17 65,484,501 (GRCm38) missense probably damaging 0.99
R1954:Tmem232 UTSW 17 65,484,487 (GRCm38) missense probably benign 0.01
R1955:Tmem232 UTSW 17 65,484,487 (GRCm38) missense probably benign 0.01
R2012:Tmem232 UTSW 17 65,500,172 (GRCm38) missense probably benign 0.21
R2294:Tmem232 UTSW 17 65,450,441 (GRCm38) missense probably benign 0.00
R2369:Tmem232 UTSW 17 65,402,997 (GRCm38) missense probably damaging 1.00
R2384:Tmem232 UTSW 17 65,402,857 (GRCm38) missense probably damaging 1.00
R2894:Tmem232 UTSW 17 65,450,413 (GRCm38) missense probably damaging 1.00
R3431:Tmem232 UTSW 17 65,265,302 (GRCm38) splice site probably null
R3788:Tmem232 UTSW 17 65,382,633 (GRCm38) missense possibly damaging 0.71
R3789:Tmem232 UTSW 17 65,382,633 (GRCm38) missense possibly damaging 0.71
R3789:Tmem232 UTSW 17 65,382,525 (GRCm38) missense probably benign 0.02
R4691:Tmem232 UTSW 17 65,265,242 (GRCm38) missense possibly damaging 0.88
R4838:Tmem232 UTSW 17 65,430,888 (GRCm38) missense probably benign 0.04
R5340:Tmem232 UTSW 17 65,402,998 (GRCm38) missense possibly damaging 0.92
R5619:Tmem232 UTSW 17 65,486,511 (GRCm38) missense probably benign 0.06
R6176:Tmem232 UTSW 17 65,485,872 (GRCm38) missense probably damaging 1.00
R6192:Tmem232 UTSW 17 65,430,805 (GRCm38) missense probably damaging 1.00
R6223:Tmem232 UTSW 17 65,500,196 (GRCm38) start codon destroyed probably null 0.99
R6256:Tmem232 UTSW 17 65,478,402 (GRCm38) missense possibly damaging 0.89
R6782:Tmem232 UTSW 17 65,500,124 (GRCm38) missense possibly damaging 0.88
R6856:Tmem232 UTSW 17 65,450,310 (GRCm38) missense possibly damaging 0.57
R7262:Tmem232 UTSW 17 65,500,117 (GRCm38) missense probably benign
R7459:Tmem232 UTSW 17 65,256,389 (GRCm38) missense probably benign 0.14
R7699:Tmem232 UTSW 17 65,265,218 (GRCm38) missense probably damaging 0.97
R7700:Tmem232 UTSW 17 65,265,218 (GRCm38) missense probably damaging 0.97
R8284:Tmem232 UTSW 17 65,402,995 (GRCm38) missense probably damaging 1.00
R8523:Tmem232 UTSW 17 65,478,371 (GRCm38) missense probably damaging 1.00
R8821:Tmem232 UTSW 17 65,436,372 (GRCm38) missense probably damaging 1.00
R9016:Tmem232 UTSW 17 65,430,783 (GRCm38) missense probably benign 0.30
R9420:Tmem232 UTSW 17 65,485,886 (GRCm38) missense probably damaging 1.00
R9617:Tmem232 UTSW 17 65,500,185 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GACATTGTGGTAAACGAGCATTC -3'
(R):5'- TGGTGCTTATGACTCCAGCC -3'

Sequencing Primer
(F):5'- ATTATTACCGATTTATACACACCAGG -3'
(R):5'- ATGACTCCAGCCTAGTATTGC -3'
Posted On 2015-05-14